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:: Volume 22, Issue 6 (2-2018) ::
__Armaghane Danesh__ 2018, 22(6): 0-0 Back to browse issues page
The effect of evening primrose oil on changes in polycystic ovary syndrome induced by estradiol valerate in rat
Abstract:   (293 Views)
Background & aim: Polycystic ovary syndrome (PCOS) is one of the most important reproductive and endocrine disorders in women. Evening primrose oil is a phytosterogenic plants,and there are positive reports about the effects of phytoestrogens on the hypothalamus-pituitary axis. Regarding the side effects of existing drugs, the aim of this study was to evaluate the effect of evening primrose oil (EPO) on changes in sex hormones, serum glucose and insulin levels and insulin sensitivity in PCOS.
Methods: In this experimental study 30 female Sprague Dawley rats with regular sexual cycle were divided into five groups (n=6). Group 1: control. Group 2: (control treatment) received evening primrose oil gavage with the dose of 1000mg/kg for 21 days. Group 3: PCOS induced by estradiol valerate. Group 4: After induction of PCOS received evening primrose oil gavage with the dose of 1000mg/kg for 21 days. Group 5: After induction of PCOS received evening primrose oil gavage with the dose of 2000mg/kg for 21 days. Finally, blood samples were collected from heart and then sex hormones and glucose and insulin concentrations were determined. The results were analyzed by SPSS software using one-way ANOVA and Duncan 's test.
Results: FSH levels in the fourth and fifth groups showed a significant increase compared to the third group (p<0.05). LH and testosterone levels in the fourth and fifth groups were significantly lower than those of the third group (p<0.05). There was no significant difference in the level of FSH and LH between the other groups. The hormone insulin and glucose concentrations in the fourth group were significantly lower than those of the third group (p<0.05). The insulin sensitivity in the treated group was significantly higher than the third group (p<0.05). There was no significant difference in insulin, glucose and insulin sensitivity among other groups.
Conclusions: Evening primrose oil, by changing the concentration of FSH, LH and testosterone hormones in polycystic ovary syndrome, can reduce the complications of these hormonal changes. EPO also reduces insulin and serum glucose and increases insulin sensitivity in PCOS. With more complete studies, Evening primrose oil can be recommended as a good alternative to chemical drugs for the treatment of PCOS.
Keywords: Polycystic ovary syndrome, evening primrose oil, sex hormones, glucose, insulin
     
Type of Study: Applicable | Subject: Physiology
Received: 2017/05/28 | Accepted: 2017/11/7 | Published: 2018/01/22
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The effect of evening primrose oil on changes in polycystic ovary syndrome induced by estradiol valerate in rat. Armaghane danesh. 2018; 22 (6)
URL: http://armaghanj.yums.ac.ir/article-1-1827-en.html


Volume 22, Issue 6 (2-2018) Back to browse issues page
ارمغان دانش Armaghane danesh
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