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:: Volume 22, Issue 5 (12-2017) ::
__Armaghane Danesh__ 2017, 22(5): 595-607 Back to browse issues page
The Effect of Rosa damascenes L. Hydro Alcohol Petal Extract on Kidney in Male Rats Treated with Arsenic
Minoo Mahmoodi 1, Siamak Shahidi 2, Marieh Mohammadi 3
1- Assistant Professor Islamic Azad University, Hamedan Branch , minoomahmoodi@yahoo.com
2- Professor , Neurophysiology Research Center, University of Medical Sciences, Hamadan
3- Msc student , Islamic Azad University, Hamedan Branch
Abstract:   (153 Views)

Aims: Sodium arsenite is an environmental pollutant which its amounts in industrial cities are more than other places because of its use in chemical industry and histopathological effects on different body organs including kidney. Rosa damascene is one of the important medicinal plants. The purpose of this study, the effect of Rosa damascene L. hydro alcohol Petal extract on kidney in male rats treated with arsenic. 
  Materials & Methods: In this experimental study 30 male rats with 200-250 gr body weight were divided randomly in to 5 groups (n=6): control, negative control (treated with arsenic) and three groups of patients were affected by arsenic and respectively with 150 mg/kg b.w ,300 mg/kg b.w and 450 mg/kg b.w Rosa damascene hydro alcohol petal extract. Arsenic was affected in drinking water groups and hydro alcoholic extract of rose petals for injection was injected intraperitoneally. After the examination the blood samples were collected from heart directly and BUN and creatinine were analyzed. Also kidney tissue samples were isolated and then fixed with formaline for thepreparation of histological sections were performed stained with H & E.  Data were analyzed using one-way of statistics ANOVA and significant level was considered of P <0.05.
  Findings: Our results showed that the arsenic has create kidney damage. Serum level of BUN and creatinine in the control group had a significant increase compared to the arsenic group (P<0.001). The situation significantly decreased on the group that treated by Rosa damascene L. hydro alcohol Petal extract extract (P<0.001).
    Conclusion:This study showed  that Rosa damascene  extract has protective compounds such as antioxidants and flavonoids which can protect from oxidative stresses and  arsenic -induced kidney toxicity.
 

Keywords: Rose petals, arsenic, creatinine, BUN, rat
Full-Text [PDF 797 kb]   (13 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2017/05/23 | Accepted: 2017/10/28 | Published: 2017/12/4
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mahmoodi M, shahidi S, mohammadi M. The Effect of Rosa damascenes L. Hydro Alcohol Petal Extract on Kidney in Male Rats Treated with Arsenic. Armaghane danesh. 2017; 22 (5) :595-607
URL: http://armaghanj.yums.ac.ir/article-1-1816-en.html
Volume 22, Issue 5 (12-2017) Back to browse issues page
ارمغان دانش Armaghane danesh
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