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:: Volume 23, Issue 3 (8-2018) ::
__Armaghane Danesh__ 2018, 23(3): 0-0 Back to browse issues page
Short-term and long-term effects of styrene on spatial working memory and locomotor activity in rat
Somayeh Arezoomandan 1
1- , arezoomandan95@gmail.com
Abstract:   (133 Views)

Background and aim: Workers in some industries exposed to styrene. This material is highly lipophilic and volatile at room temperature and the brain tissue has high fats. Therefore, it can cause various neurological effects, including memory impairment. On the other hand, memory plays a very important role in everyday life and work environment. The present study was performed to investigate the short and long-term effects of styrene on spatial memory and locomotor activity of male rats.
Methods: For this experimental study،, twelve Wistar male rats were divided randomly into two groups as case and control. In case, group animals were exposed to styrene (750 ppm, 6hr/day, 5 days/week) for 21 days. In control, group animals were in the same condition but did not expose to styrene. 2 days following termination of styrene exposure, spatial working memory, and locomotor activity was evaluated by Y maze and open field test. In order to investigate the long-term effects of styrene, these tests were repeated 3 weeks after termination of exposure. In this study, spontaneous alternation as spatial working memory index, velocity and traveled distance as indicators of locomotor activity and spending time in the center as an indicator of non-anxiety were studied.
Results:  Obtained results showed that 2 and 21 days after termination of styrene exposure, the time spent in the center of an open field box, traveled distance and velocity were significantly decreased. These effects were higher at 21 days compared to 2 days following styrene exposure. Similarly, styrene exposure led to a significant decrease in spontaneous alternation and total arm entries in the Y-maze test.
Conclusion: According to the results, exposure to styrene leads to a decrease in the activity of the rat, and this effect intensifies over time for 21 days. Exposure to styrene also causes spatial memory impairment in the rat, but this disorder does not increase with time.

Keywords: styrene, spatial working memory, locomotor activity, male rat
Type of Study: Applicable | Subject: Occupational Health
Received: 2016/11/18 | Accepted: 2018/07/24 | Published: 2018/08/3
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arezoomandan S. Short-term and long-term effects of styrene on spatial working memory and locomotor activity in rat. Armaghane danesh. 2018; 23 (3)
URL: http://armaghanj.yums.ac.ir/article-1-1584-en.html

Volume 23, Issue 3 (8-2018) Back to browse issues page
ارمغان دانش Armaghane danesh
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