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ABSTRACT Introduction & Objective: Plastination is a unique technique(was developed by gunthea hagen’s in 1984) involves substituting the tissue water in a specimen with polymer. The aim of this study is plastination of 3.5-5 months human aborted fetuses. Materials and Methods: This is a experimental applied study. 12 human aborted were plastinated after fixation in formalin solution, clearing in hydrogen peroxides, dehydration by acetone and forced imperegnation was carried. In the last step curing shrinkages was removed by positive pressure anatomical spaces. The data was analysed by T & Mann whitney. Results: Samples were obtained in this study compared with the samples. Two sampels have the same durablity but flexibility resin sampel are more than silicones , probably besause of insertion glycerin to resin polyester. Also matching of aboartion steps of forensic medicin was done in this collection . Conclusion: A collection of 12 plastinated aboarted human fetuses were prepared and matchs the samples with the definition of forensic medicine. Silicone substituted by cheap resin polyester asseptable samples were obtained. Plastinated fetuses are usefull for teaching of embryology and forensic medicine for the medical students.

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Backgrounds & aim: Vitexagnus-castus as an herbal medicine has been used for the treatment of female reproductive disorders. The aim of this study was to evaluate the effect of ethanol extracts of Vitexagnus-castus on placental histomorphology in rat models. Methods: In the present experimental study, fourty pregnant rats were randomly divided into four groups (n=10). A control group received only distilled water and three experimental groups were treated with extract of Vitexagnus-castus at doses of 25, 50 and 75 mg/kg at days of six to the seventeenth of intraperitoneally administration. On day of18 of gestation, after anesthesia with chloroform half the animals in each group were killed and histomorphological study was calculated. After delivery the resulting offspring of the other half of animals in each group was counted and survival rates at days 5, 15, 25 and 42 after birth were decreased. The results were analyzed by one-way ANOVA test. Results: Treatment with 50 mg/kg VAC extract reduced the size and number of trophoblast giant cells, and significantly increased trophoblast cells glycogen. Treatment with 75 mg/kg extract induced massive hyperemia in the labyrinth interhemal membrane. In addition, in the all experimental groups the number of neonates was drastically decreased on days 5, 15, 25, and 42 after birth. Conclusion: Vitexagnus-castus extract alters the structure of the placenta and may be impaired its function. Cautious should be recommended for oral consumption or medicinal plants, especially in pregnant women.

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Background & aim: Cyclophosphamide, an alkylating agent used in the treatment of cancer that has many side effects on different organs, including the gonads .The purpose of this study was to investigate the effects of an antioxidant Ellagic acid on cyclophosphamide -induced toxicity in rat fetal ovarian tissue.

Methods: Forty two pregnant  female Wistar rats weighing 250-200 gr were randomly divided into seven groups.The first, second, third, fourth, fifth and sixth 5 mg/ kg cyclophosphamide on days 1, 13 and 18 were given intraperitoneal remote pregnancy .The fourth, fifth and sixth groups hour after receiving cyclophosphamide, Ellagic acid (10 mg/kg) has received in the course of pregnancy.Control groups and seven group (normal) during pregnancy daily orally received 0.5 mL of saline. After postpartum, Neonatal rats were anesthetized with ether. Animals were dissects, then Ovaries were removed and transferred to 10% formalin solution. After tissue processing, tissue sections were prepared and H&E stained.Data were analyzed by SPSSsoftware and One- way ANOVA test.

Results: The groups that were exposed to cyclophosphamide ovarian mean of diameter, primordial follicle diameter and number of follicular cell of primordialin control group compared to ellagic acid treatments showed a significant decrease.

Conclusion: The results showed that Ellagic acid due to its antioxidant properties could reduce the harmful effects caused by cyclophosphamide in the fetal ovary.

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Background & aim: Sacrococcygeal teratoma (SCT) is one of the most common neoplasms diagnosed during pregnancy. Sacrococcygeal teratoma is classified into four types according to the location of the lesion. Type 4 tumors are usually diagnosed in the postpartum period and have a higher potential for malignancy. The aim of the present study was to report a case of prenatal diagnosis of sacrococcygeal teratoma.

Case report: The patient was a forty-year-old woman with her second pregnancy, who had a cystic lesion in the fetal abdomen without any symptoms in the routine screening ultrasound of the second trimester, and was referred to our center due to this lesion at the gestational age of 21 weeks and 5 days. In the ultrasound performed in this center, a lesion with dimensions (39.5 x 14.3 x 8.62 mm) was detected in the fetal pelvis in front of the sacrum, tumor growth and fetal heart failure were followed up with serial ultrasound. A caesarean section was performed at the 39th week of pregnancy due to the previous caesarean section of the mother, and the baby's surgery was successfully performed 72 hours after birth. The answer to the pathology of adult cystic teratoma was reported and follow-ups of the control indicated the normal and healthy growth of the child. The early diagnosis and monitoring and treatment of the disease were done by using Prenatal ultrasound evaluation.

Conclusion: Prenatal ultrasound evaluation was important in both diagnosis and monitoring of tumor growth in order to detect perinatal complications such as heart failure and fetal hydrops. These prenatal assessments can lead to accurate diagnosis and appropriate treatment.