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Showing 2 results for Type 1 Diabetes
Ar Fallahzadeh , F Poursaidi , S Einaloo ,
Volume 10, Issue 4 (1-2006)
Abstract
Introduction & Objective: Diabetes mellitus is the most common endocrine disorder of childhood which is caused by relative or absolute deficiency of insulin. Diabetes can cause alteration in some elements of the body such as magnesium. This study was conducted for further evaluation of this matter and also to find out any relationship between level of serum magnesium and duration of diabetes.
Materials & Methods: In this study blood sample (2 ml) was taken from 27 diabetic and 27 healthy children. Blood samples were freezed till the end of sample collecting when they were checked for the level of magnesium.
Results: Results of this study show that the level of magnesium in serum of diabetic children is lower than that in the healthy ones, but this difference is not statistically significant. In addition, no correlation was found between the duration of diabetes and the level of serum magnesium.
Conclusion. Further study is needed to evaluate this matter in details by measuring the intracellular magnesium for example in blood cells by more sophisticated experiments.
F Malekifar, N Delirezh, R Habnagh, H Malekinezhad, ,
Volume 20, Issue 2 (5-2015)
Abstract
Background & aim: Pentoxifylline is an immunomodulatory and anti-inflammatory agent which inhibits the production of proinflammatory cytokines. The purpose of this study was to evaluate the effect of pentoxifylline in the treatment of type 1 diabetes in mice and its effect on the expression of peroxisome proliferator- activated receptor gamma (PPARγ).
Methods: After induction of diabetes in male C57BL/6 mice, they were treated with Pentoxifylline (100 mg/kg/day) for 21 days. Blood sugar levels were measured on days 0, 7, 14 and 21. Splenocytes were tested for cytokines production by ELISA. Further investigations on immune system changes in spleens were tested by semi-quantitative RT-PCR on PPARγ gene. Statistical data were analyzed using the Student t-test and ANOVA.
Results: Treatment with pentoxifylline prevented the level of blood sugar in diabetic rats. Pentoxifylline treatment also significantly inhibited the production of proinflammatory cytokines IL-17 and IFN-γ, while cause increasing the anti-inflammatory cytokine IL- 10 and the expression of PPARγ gene in the spleen compared to the diabetic control group (p< 0.05).
Conclusion: Due to STZ induction, Pentoxifylline may have therapeutic effects against autoimmune destruction of pancreatic beta cells on type 1 diabetes in mice
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