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Background & aim: Esophageal cancer is the eighth most prevalent cancer worldwide and the second in Iran. Annually, esophageal cancer makes up 3.2% of all new cancer cases. Altered expression of stem cells self-renewal genes is of great importance in the tumorigenesis. The aim of this study was to compare the TBX3 gene expression in tumoral samples of patients with squamous esophageal cancer and normal tissue samples of healthy individuals.

 

Methods: The present cross-sectional study was performed on 40 samples, including 20 samples of tumor esophageal cancer tissue and 20 samples of normal tissue samples from Imam Khomeini Hospital in Ahwaz, Iran. After extracting RNA from FFPE tissues and synthesizing cDNA, expression levels of TBX3 and GUSB (as internal control) genes were relatively quantified using qRT-PCR. Data were analyzed using t-test.

 

Results: The results of the qRT-PCR analyses showed that the average relative gene expression in tumor samples was higher than normal samples. Furthermore, TBX3 gene expression exhibited greater expression in the tumor samples of the patients in the 26-50 years age range in compared with the 51-81 years age range

 

Conclusion: According to the cancer stem cell theory, many tumors originated from stem cells leading to the inhibition of apoptosis and resistance to chemotherapy. Considering the role of TBX3 gene in self-renewal of stem cells and its increased expression in patients with squamous esophageal cancer, it seems that TBX3 gene might be used as a biomarker in the diagnosis and prognosis of esophageal cancer in future.

 

 

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Abstract                
Background & aim: Esophageal cancer is the eighth common cancer worldwide. In recent years, the improvement in surgical procedures and pre and postoperative care has reduced its incapacity and mortality rates in the intensive care unit. The aim of this study was to investigate the early outcomes of patients with esophageal cancer who were admitted to the intensive care unit of Urmia Imam Khomeini Hospital during 2011-2017.
 
Methods: This retrospective cross-sectional study was performed in the intensive care unit of Imam Urmia Hospital during a 7-year period (2011-2012). , Type of surgery, duration of mechanical ventilation, length of stay in intensive care unit, mortality were extracted. The data were analyzed using independent t-test and chi-square test
 
Results: The mean length of admission in the ICU among patients with SCC esophageal cancer was 8.46 ± 5.86 days and among adenocarcinoma patients was 6.74 ± 3. 59 days (P = 0.001). The mean length of hospitalization among patients with SCC esophageal cancer was 13.19 ± 6.4 and was 12.02 ± 6. 02 days, respectively (P = 0.04). Mean duration of mechanical ventilation among patients with SCC esophageal cancer was 5.58 ± 5.31 days and 4.69 ± 2.91 days among patients with adenocarcinoma. (P=0.001). Of 481 patients with esophageal cancer, 375 (78) discharged and 106 (22%) died.
 
Conclusion: The results of the present study confirm the limited results of limited studies on the outcome and characteristics of patients with operated esophageal cancer admitted in ICU.