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Introduction & Objective: Cardiovascular diseases represent the number one of causes of death in the United States. In addition to traditional medical treatment, alternative pharmacotherapy ,such as the use of vitamins, has been studied or tried by patients suffering from cardiovascular diseases. Antioxidant vitamins are the most frequently used medications in this regard. The aim of this study was to investigate the effect of vitamin E or combination of vitamin E and vitamin C on blood cholesterol, triglycerid, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) of patients undergoing lovestatin treatment. Materials & Methods: In a clinical trial, 93 hyperlipidemic patients were chosen and assigned in one of three drug groups. Group one received lovastatin plus placebo tablets. Group two received lovastatin plus vitamin E (400 IU), and group three lovastatin plus vitamin E and vitamin C (1000 mg) per day. Blood cholesterol, triglycerid, LDL, and HDL were measured before and following 10 weeks of medication. Results: Following 10 weeks of drug use, blood cholesterol, triglycerid and LDL were less and HDL was higher than these parameters at the beginning of the study. Comparison of results between three groups showed that the stuided parameters were not different in group three compared with group two, except for LDL. Conclusion: Adding antioxidant vitamins, particularly vitamin E, to medications of hyperlipidemic patients might be beneficial to these patients.

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ABSTRACT: Introduction & Objective: Eczema is one of the most common pruritic skin disorders for which various treatments are used to relieve the symptoms. There are several reports about the efficacy and in part safety of topical doxepin in the treatment of pruritic dermal diseases. However, lack of a suitable topical preparation from this drug in our country persuaded us to design the present trial. Materials & Methods: A randomized, double blind, placebo- controlled and multi- centeral clinical trial was carried out in Isfahan during the years of 1383-84 by using 60 volunteers and both the drug and placebo were given QID for 8 days. The efficacy, side effects and their relevance to sex and age of subjects were assessed before, during and after the treatment. The data were analyzed using non-parametric tests including Mann-Whitney, Wilcoxon, and Kendall Tau where appropriate. Results: Results indicated that doxepin cream effectively reduced disease symptoms including pruritus (75.5%), inflammation (43.8%) skin dryness (37.5%) exudates (59.5%), lichenification (41.5%), and eczema (41.5%) after the course of treatment (the day of 8). Same results were obtained by using placebo. Stinging as an adverse effect was occurred in both the drug (30 %) and placebo (27%) groups. Conclusion: Although there was no significant difference between the two groups, it can be concluded that doxepin cream (5 %) is effective in depressing the signs and symptoms of pruritic skin disorders. A larger clinical trial is needed to evaluate the efficacy and safety of the product more precisely.

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ABSTRACT: Introduction & Objective: Coronary artery disease is the main cause of mortality in developing countries like Iran. Due to failure of classic risk factors to completely explain epidemiologic variability of the disease, other risk factors, for example infection diseases are under investigation. One of these infectious agents is Helicobacter pylori which have been investigated in numerous studies. This study was designed to assess the controversies about Helicobacter pylori prevalence in acute coronary syndrome, Materials & Methods: All the patients with ACS including unstable angina and myocardial infarction who referred to Fatemie Hospital between 20 Feb 2003 to 9 Feb 2004 and were admitted in CCU ward were included in this cross–sectional study. A total of 411 patients with ACS were evaluated for prevalence of Helicobacter pylori antibody. Results: Mean age of patients was 59.97and 56% of them were male. The serological test for Helicobacter pylori infection was positive in 45.6% of cases, negative in 43.8% and borderline in 10.6% of patients. 191 patients had unstable angina and 220 patients had myocardial infarction. Conclusion: This study showed that prevalence of Helicobacter pylori infection in patients with acute coronary syndrome was not high. Thus acute or chronic infection with Helicobacter pylori could not be a risk factor for ACS.

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Introduction & Objective: Lead contamination dramatically influences different body systems especially the central nervous system. Lead absorption during gestational period has deleterious effects on fetal differentiation and development and it may possibly result in learning deficits in adulthood. Recent studies have demonstrated positive effects of Melissa officinalis on memory improvement in some neural disorders. The aim of the present study is to investigate the protective effects of Melissa on learning deficits in lead acetate exposed rats. Materials & Methods: In this experimental study in department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad (2008-2009), 40 mated Wistar rats were divided into 8 groups as follows: control, negative control (Pb), Melissa (M) and Pb+M, and each in 3 different subgroups. The treatment started from the 7th day of gestation and continued during pregnancy and lactation. The learning ability and memory retention of four months old offspring were tested by complex T-maze. The collected data was analyzed by the SPSS software using one-way ANOVA and Toki test. Results: A significant difference was found between lead exposed group and other groups regarding the time to reach the goal and the number of errors while there was no meaningful difference between the control and other experimental groups. Conclusion: In lead exposed rats, learning deficits were obviously noticed. Since there was meaningful difference between control and Pb+M subgroups, Melissa can possibly improve learning deficits in lead acetate exposed rats.

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Introduction & Objective: Preeclampsia is a disease with worldwide importance to mothers and infants, where it accounts for 20–80% of the strikingly increased maternal mortality. The lack of enzymes added to the homocysteine metabolism or the cofactors necessary for its metabolism (folate, B6 vitamin, B12 vitamin) cause hyperhomocysteinemia. Abnormal serum lipid profiles such as cholesterol, LDL, HDL and triglyceride are associated with endothelial dysfunction. Recently high levels of B-HCG have been identified as a potential marker for developing preeclampsia. The purpose of this study was to identify the possible association of homocysteine, vitamin and some serum factors levels with preeclampsia in pregnant women. Materials and Methods: A case control study was performed prospectively on normotensive healthy pregnant women (80) and pregnant women diagnosed with preeclampsia (80) referring to Imam Sadjad hospital in Yasuj, between September 2004 to August 2005. In addition to the obstetric evaluation and laboratory examination in the 3rd trimester of gestation, blood samples were taken from all cases for homocysteine and vitamin B12, folic acid, triglyceride, cholesterol, LDL, HDL, B-HCG analysis. The samples were evaluated by Immunoassay (ELISA). Univariant and logistic regression analyses were used to identify predictors of outcomes. Results: The mean plasma level of total homocysteine was significantly higher in preeclamptic women compared with normal pregnancy(p<0/05). No significant differences were observed in B12 concentrations and plasma folic acid (P>0.05). Triglyceride and cholesterol levels were significantly higher in preeclamptic women compared with normal pregnant women(p<0/05). LDL and HDL levels were not correlated with preeclampsia. There was no significant association between preeclampsia and B-HCG levels. Conclusion: Homocysteine, triglyceride and cholesterol concentrations increase in preeclampsia but decrease of vitamin B12 and folic acid levels was not observed in preeclampsia. LDL, HDL and B-HCG levels were not different between preeclamptic women and women with normal pregnancy.

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Background & aim: Authority delegation means to transmit part of organization`s manager and leader`s special authorities and executive duties, regardless its root to subordinates and heads of units and related offices to speed up implementing affairs and organizational purposes quickly and on time. The purpose of this study was to inspect authority delegation in health centers of Boyerahmad district through using model to combine suggestions (to identify process) and Delphi method (expert`s opinions) . Methods: This cross-sectional study was implemented in two stages at first stage, research community was authorities of Boyerahmad health centers (58 persons), their suggestions about requested processes to delegate were gathered by total count through open questionnaires and in second stage, which was Delphi, suggestions gathered from previous stage judged by 30 experts. Data of both stages analyzed by help of Chi-square, correlation coefficient tests. Results: Findings showed that 73.85% of suggestions were able to be delegated, based on expert`s opinion. 40% of suggestions were in domain of official, 36.92% financial and 23.08% hygienic. 88% less than 6 years management background. 20.69% had no academic studies and only 27% were general physicians. Conclusion: By participation of environmental management levels, several processes may be specified and identify cases which are possible to delegate them executively using Delphi (expert`s opinion) and this model can be used as a trust worthy method to delegate authority for decentralization. Key words: Participation Management, Health centers, Authority delegation

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Backgrounds & aim: Hypericum is a traditional medicinal plant that used for the topical treatment of superficial wounds, burns and dermatitis.the aim of this study was to evaluate the effect of Hypericum perforatum extract and1 % silver sulfadiazine on a second degree burn wound healing in the male rat. Methods: This experimental study was performed on 30 adult male Wistar rats weighing 50 ± 200 gr. To make the second degree burns wound at area of 2 square centimeters with boiling water, animals were anesthetized using sodium thiopental . The animals then divided into three equal groups randomly. Control group was washed with sailine every day. The second and the third groups were treated with 1% silver sulfadiazine ointment and Hypericum perforatum extract respectively. After thirty-five days of treatment, mice were anesthetized and tissue samples were taken for processing and staining with hematoxylin and eosin and examined under light microscope. Data were analyzed using one-way ANOVA Results: Average surface burns,thickness of the epidermis and malondialdehyde levels in HP treatment compared with 1% silver sulfadiazine was close to normal control but no significant differences was found between Hypericum perforatum extract and silver sulfadiazine at duration of treatment (p> 0.05). Conclusion: Although there was no statistically significant difference, but the restorative effects of HP -treated group compared with the other groups showed better result.

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Background & aim: The food that man needs is produced in a relatively long chain and after various stages of procurement, transportation, processing, storage, packaging and finally consuming, thus proper management of this chain is of great importance for providing health . The purpose of this study was to design and develop an appropriate and native model for controlling food health control in Kohgiluyeh and Boyer Ahmad Province using the experience and nutrition models of several developed countries and the views of experts and nutritionists.
 
Methods: The present study applied a qualitative-quantitative and applied-qualitative, descriptive and comparative method was used in a cross-sectional mannerin. At the initial design stage, the model initially identified several factors and program aspects Management and food safety, and food safety monitoring of food products in the country (province) and selected countries. Primary criteria and components of applied questionnaires were developed using the theory of nutrition experts and experts in this field, extracted, classified and tailored to the specific objectives of the study. To test the pattern with a survey approach by receiving the views through a questionnaire in three stages, the review and necessary amendments were made based on the proportion of each of the indicators and criteria. The methods of analysis are mainly descriptive and conceptual analysis, Structural modeling analysis tool and use of LaserLevel software.
 
Results: This model was developed in the form of 80 sub-components, and four main factors, including: factors affecting food control management 33 factors, 28 factors planning, organizing monitoring, 12 factors and factors influencing the financing of health control management Food is 7 factors.This pattern can be used as a framework for ensuring the quality and safety of the food industry. Finally, in order to determine the appropriateness of the proposed model and its adaptation to the needs and requirements of the industries and companies and food and nutrition management unit organizations, using the hierarchical analysis method, the importance coefficients of each dimension, components and indicators available in the pattern for the country of Kohgiluyeh and Boyerahmad Province.
 
Conclusion :This study may be useful in providing an appropriate management system for managing food health control in Kohgiluyeh and Boyerahmad Province, which provides the improvement of the state of health of the food industry, an appropriate technique for monitoring and control in organizations that are part of their duties in the field of food .
 
 

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Abstract
Background & aim: S-triazine, is one of the most widely used herbicides of estrazines, and             S-triazine, contains of atrazine, amtryn and prom ether. S-triazine is one of the most stable herbicides that pollute water resources.  This material is used for controlling broad-leaved weeds and corn. The purpose of this study was to determine the bioavailability of SBR bioreactor enzyme inhibitor, which was stimulated with hydrogen peroxide.
 
Methods: in this biodegradation enzyme study which took place in 2017, the toxin-induced enzymatic biodegradation of atrazine in a sequencing batch reactor (SBR) was performed. Synthetic sewage was prepared by dissolving 1 gram of atrazine powder in 1000 ml distilled water. Different stages of the experiment included enrichment of atrazine degrading bacteria and determination of initial concentration of atrazine (10025 mg / l), determination of the effect of hydrogen peroxide concentration (H2O2), determination of reaction time and microbial activity. The pH of the test was stationary at 7. The concentration of atrazine was measured by HPLC.
 
Results: The validity of this study was 72 days. The number of days required to completely eliminate atrazine was reduced and from 32 days in the first stage, it was reduced to 1 day. The optimal H2O2 / ATZ ratio was 11, with atrazine concentration of 25 mg / L with a concentration of 7.5 mmol per hour at the reaction time (HRT) of 24 hours completely eliminated. In atrazine concentrations, 25 and 100 mg / l were eliminated at 15 and 54 hours, respectively. With increasing atrazine concentration from 25 mg/l to 50 mg / l, the activity of the enzyme dehydrogenase increased from 8.8 to +9.7 TF/g _biomass.d. was increased.
 
Conclusion: Based on the results of this study, atrazine decomposition using peroxidase enzyme in the presence of hydrogen peroxide is an effective and novel biodegradable enzyme for the complete decomposition and removal of this pollutant from contaminated water and sewage.