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Introduction & Objective: Transurethral resection of prostate (TURP) is the operation most frequently performed in urology. In view of the morbidity associated with this procedure, research has been conducted to propose an endoscopic alternative to TURP. Using of high energy laser is the most promising method in these cases. In this study, we evaluated the effect of home made KTP laser on re-sected prostate adenoma after open prostatectomy. Materials & Methods: 40 patients complaining of symptomatic BPH were treated by open prostatectomy. These 40 prostates were divided in to two parts. One part was sent for pathology assessment (group A) and the other part was sent to KTP laser room in the same hospital (group B). The prostates in group B were divided into 4 groups (1, 2, 3, 4), each with 10 prostate tissue. In groups 1, 2, 3 and 4, prostate lobes underwent laser ablation in one, two three and four stage. In any stage, KTP laser, 5 watts for 15 seconds, was used. All of prostate ablated with laser were sent to pathology for evaluation of tissue ablation capacity and deep tissue penetration. The study in all of stages was blinded for pathologist. Results: Mean age of participants was 73.25±6.8 years and mean level of PSA was 3.65±2.1 ng/dl. In both groups, with every stage laser, we have 1 to 2 mm tissue ablation associated with prostate type. In pathologic examination, we have 0-2 mm tissue destruction with disappearance of cells' nuclei, basophilia of stroma and damaged tissue (cutter like effect). Findings were compatible with burn effect. Conclusion: Pathologic findings proved, in the ex vivo investigation, that KTP laser offers a good tissue ablation capacity and minimal microscopic tissue damage. The risk of capsule perforation is very low. This procedure is safe and effective in which bladder outlet obstruction symptoms will be quickly relieves and has a low rate of complications. Moreover KTP laser has much cost effectiveness, although we need further studies on live prostatic tissues

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ABSTRACT: Introduction & Objective: Transitional cell carcinoma of renal pelvis presenting with brain metastases is a very rare case which should be diagnosed and treated in order to prevent further damages. Case: We report a rare case, who had presented with a constellation of neurological symptoms (due to multiple brain metastases), but without any urological symptoms. During evaluation of patient, we found transitional cell carcinoma (TCC) of left renal pelvis, for which palliative radical nephroureterectomy was performed . Conclusion: Although transitional cell carcinoma of renal pelvis presenting with brain metastases is a very rare case, but the patient was managed with gamma knife stereotactic radiosurgery for the metastatic lesions. Afterward he received four cycles of paclitaxel and carboplatin chemotherapy. The patient is alive with stable disease at 32- months’ follow-up.

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Background & aim: COVID-19 has numerous and diverse clinical symptoms in different groups, which highlights the identification of common symptoms in children as silent carriers and the timely identification of patients to control the spread of this disease. Therefore, the aim of the present study was to determine and investigate the prevalence of clinical symptoms of COVID-19-19 in children.

Methods: The present review and meta-analysis study was conducted according to PRISMA guidelines. The prevalence of symptoms as identification factors of children with COVID-19 at the time of arrival to the hospital between January 2020 and April 2022 was investigated. Articles used in international and domestic databases using the keywords "children", "children", "Covid-19", "symptoms", "clinical symptoms", "fever", "diarrhea", "vomiting" ", "shortness of breath", "cough", "headache", "nausea", "shivering", "body pain", "fatigue" and "malaise" were searched. The collected data were evaluated using the Egger test to check the diffusion error and heterogeneity using the I2 test.

Results: In order to determine the prevalence of symptoms of covid-19 in children, a total of 261 articles were received, and finally 21 articles were considered in the analysis. In general, 2200 patients were examined in the present study. According to the results, fever with an overall prevalence of 47% and a confidence interval of 95% (38.96-50.50) is the highest symptom and diarrhea with an overall prevalence of 6.69% and a confidence interval (5.42-8.05) is the lowest.

Conclusion: According to the results of the present study, fever and cough were two prominent symptoms of the covid-19 disease in children, and considering that these two symptoms are common symptoms in most children's diseases, during the current epidemic, it is necessary to identify sick children or be considered contaminated.