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Showing 2 results for Dezfulian
Sh Zahiri , Ar Dezfulian , F Dehghani,
Volume 11, Issue 1 (4-2006)
Abstract
ABSTRACT:
Introduction & Objective: Cisplatin is a potent antineoplastic drug. The beneficial effects of the drug are limited by its nephrotoxicity. The purpose of this study is to introduce sterological meothds (Estimation of mean glomerular volume) to determine the toxicity of drug & examine the Galium aparine (a traditional herbal plant) as a protective agent.
Materials & Methods: This experimental study was done in histology department in Ahwaz University of medical sciences in 1380. 70 Spraque–Dwally male rats were iselected randomly and divided into 7 groups as below: two control groups (one for drug & one for plant), five experimental groups one treated by acute dose of drug (7.5 mg/kg, IP) and other groups treated with 4 doses of hydroalcholic extract of plants (4, 8, 16, 32 mg/kg) half an hour before receiving drug orally. Animals were sacrified 96 hour after receiving the drugs and their right kidneys were processed for stereological assessment based on cavalier method. Statistical analysis of data from calculation of mean glomerular volume was done by ANOVA and two sided-dunet test, using SPSS software.
Results: The results based on cavalier method, showed an increase in mean glomerular volume in all the groups that were treated with drug, whereas lower grade of glomerulomegaly was seen in those groups which received higher doses (16 & 32 mg/kg) of plant’s extract (p<0.05).
Conclusion: Nephrotoxicity induced by cisplatin was even observed in quantitative parameters of kidney (e.g. increasing the mean glomerular volume) but by using Galim apain’s extract this side effect can be reduced significantly. Moreover stereological techniques are valuable tools for studying the drug effects in all organs of the body.
M Azimpour, M Fathi, O Dezfulian,
Volume 26, Issue 3 (7-2021)
Abstract
Armaghane-danesh, Yasuj University of Original Article
Medical Sciences Journal (YUMSJ)
The Effect of Eight Weeks of Royal Jelly Consumption on Some of Apoptotic Indicators in Trimethyltin-Induced Alzheimer's Mice
Azimpour M, Fathi M*, Dezfulian O
Department of Physical Education, Lorestan University, Khorramabad, Iran
Received: 05 Sep 2020 Accepted: 10 Oct 2020
Abstract:
Background & aim: Given that Royal Jelly contains compounds that have beneficial effects on the central nervous system and neural functions, therefore, the aim of this study was to determine and evaluate the effect of Royal Jelly consumption on apoptotic indices in trimethyltin model of Alzheimer's disease.
Methods: In the present experimental study conducted in fall of 2018, 32 male Sprague-Dawley rats were included in the study. Twenty-four of them were induced by Alzheimer's induction by trimethyltin. The rats were then randomly divided into four groups: healthy last week, victim control last week, sham and royal jelly. The expression of P53, BAX, BCL-2 genes were measured by Real Time PCR technique. Data analysis was performed by Manova test and post hoc Scheffe at the significant level P<0.05 using SPSS software version 20.
Results: The findings of the present study indicated that the dependent variable P53 in the last week Alzheimer's group was more than the healthy groups in the last week and gel. Moreover, the dependent variable P53 in the sham group was more than the healthy groups in the last week and the gel. In the healthy group, the last week was less than sham and Alzheimer's last week. BCL-2 in the gel group was more than sham and healthy last week and Alzheimer's last week and in the healthy group last week was more than sham and Alzheimer's last week.
Conclusion: Trimethylmethine administration may be involved in selective neuronal death and mitochondrial apoptotic pathways in neurodegenerative disorders, and royal jelly supplementation may be used as an inhibitor of the internal pathway of apoptosis and to enhance neural function and neuronal regeneration in the present model.
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