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Background & aim: recurrent miscarriage is defined as accruing of at least 3 clinical spontaneous abortions or more. Several factors including genetic and environmental factors are involved in it. Among them, sulftase1 gene rs2623047 has a role in the human embryonic development. The purpose of this study was to evaluate sulftase1 gene rs2623047 polymorphism in women with recurrent abortions referred to the infertility center of Yazd, Iran. Methods: In the present case-control study, sixty-five healthy women were selected as controls and thirty-five women with recurrent miscarriage were included as cases. Blood samples were taken from both groups manually, using a low-salt DNA extraction and amplified fragment polymorphism rs2623047 1 sulfatase gene made by PCR and enzymic digestion conducted using BstNI enzyme. Results were analyzed using the chi-square test. Results: GG genotype in cases were 42±9% and in control group 5/18% respectively (p=0.003). While the AG genotype in the control group was 9.56% and in the cases 1.37% (p=0.003). Conclusions: Genetic variation in sulfatase 1 gene may have a role in embryonic development during pregnancy and larger studies with more samples along with other polymorphisms in this gene may be helpful.

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Abstract

Background and Aim: Leishmaniasis is one of the most common epidemic diseases in tropical regions of the world. The disease is affected by economic, social, cultural, environmental and climatic factors. Fars province is one of the areas with high prevalence of this disease. Due to the occurrence of climate change in recent years in the country and in this province, the present study was conducted to evaluate the epidemiology of cutaneous Leishmaniasis in Marvdasht city in 2017.

Methods: This descriptive-analytic study was conducted on the epidemiology of cutaneous Leishmaniasis in Marvdasht city in 2015. Accordingly, demographic data of all patients registered in the Marijuana Medical Center's Marijuana Infection Unit were extracted and analyzed by descriptive statistics, independent t test, and Kruskal Wallis using SPSS version 16 software.

Results: The incidence of disease in the whole population was 13.44, in men 14.4 and in 12.4% in 10 thousand people. Most cases were in the age group of 21-30, housewives, and villagers. The hands had the most lesion and most people had more than 5 lesions. Also, the incidence of illness in the fall season was higher than in other seasons. There was no statistically significant difference in the incidence of disease based on gender (p <0.05).

Conclusion: Based on the results of this study, the incidence of cutaneous Leishmaniasis in the city of Marvdasht is high and there is no significant difference in gender-related illness. The incidence of illness was higher in housewives and residents of the city. As a result, appropriate health Proceedings, including controlling the vector and the reservoir of the disease, should be carried out by the authorities through the spraying and optimal treatment of patients, so that the spread and spread of the disease and the subsequent prevention of disease can be prevented.

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Background & aim: Parkinson's disease is a disorder in the nervous system due to the degeneration of dopaminergic neurons. Dopaminergic system is susceptible to neurological disorders caused by exposure to stressors early. Positive experiences are one of the most powerful treatments to increase neuroplasticity and motor function at any time of life. The purpose of the present study was to investigate the effect of pre-treatment endurance training on the balance of Parkinson's rats with perinatal stress.
 
Methods: In the present experimental study, 48 neonates rats of 30 days of age, with half of them under perinatal stress, were randomly divided into 8 groups consistening of no stress groups (control, sham, parkinson, endurance training + Parkinson's) and stress groups (control, Sham, Parkinson's, Endurance Exercise + Parkinson's). After 8 weeks of endurance training, stereotoxic surgery was performed on mice to create a Parkinson's model. After three weeks, theapomorphine test was used for diagnosis of Parkinson's disease and balance beam equilibrium test. Data were analyzed by one-way ANOVA and Tukey's post hoc test.
 
Results: The results indicated that the endurance exercises improved balance in both groups with and without prenatal stress(p<0.05). Furthermore, prenatal stress reduced balance, but this reduction was not significant(p=0.059), and perinatal stress also reduced the beneficial effects of exercise on balance test(p <0.05).
 
Conclusion: According to the findings, perinatal stress seems to reduce the balance of Parkinson's rats and endurance exercises reduce the negative effects of perinatal stress, which leads to a reduction in the negative effects of Parkinson's on balance.