[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 11, Issue 1 (4-2006) ::
__Armaghane Danesh__ 2006, 11(1): 35-43 Back to browse issues page
Clinical Evaluation of a Topical Doxepin Cream (5%) in Treatment of Eczema
M Minaiyan 1, N Tavakoli, A Momeni, F Ahmadi
1- , Minaiyan@pharm.mui.ac.ir
Abstract:   (6589 Views)
ABSTRACT: Introduction & Objective: Eczema is one of the most common pruritic skin disorders for which various treatments are used to relieve the symptoms. There are several reports about the efficacy and in part safety of topical doxepin in the treatment of pruritic dermal diseases. However, lack of a suitable topical preparation from this drug in our country persuaded us to design the present trial. Materials & Methods: A randomized, double blind, placebo- controlled and multi- centeral clinical trial was carried out in Isfahan during the years of 1383-84 by using 60 volunteers and both the drug and placebo were given QID for 8 days. The efficacy, side effects and their relevance to sex and age of subjects were assessed before, during and after the treatment. The data were analyzed using non-parametric tests including Mann-Whitney, Wilcoxon, and Kendall Tau where appropriate. Results: Results indicated that doxepin cream effectively reduced disease symptoms including pruritus (75.5%), inflammation (43.8%) skin dryness (37.5%) exudates (59.5%), lichenification (41.5%), and eczema (41.5%) after the course of treatment (the day of 8). Same results were obtained by using placebo. Stinging as an adverse effect was occurred in both the drug (30 %) and placebo (27%) groups. Conclusion: Although there was no significant difference between the two groups, it can be concluded that doxepin cream (5 %) is effective in depressing the signs and symptoms of pruritic skin disorders. A larger clinical trial is needed to evaluate the efficacy and safety of the product more precisely.
Keywords: KEYWORDS: Clinical evaluation, Doxepin, Eczema, Skin, Topical cream
Full-Text [PDF 125 kb]   (1013 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/06/6 | Accepted: 2015/06/6 | Published: 2015/06/6
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Minaiyan M, Tavakoli N, Momeni A, Ahmadi F. Clinical Evaluation of a Topical Doxepin Cream (5%) in Treatment of Eczema. Armaghane danesh. 2006; 11 (1) :35-43
URL: http://armaghanj.yums.ac.ir/article-1-741-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 11, Issue 1 (4-2006) Back to browse issues page
ارمغان دانش Armaghane danesh
Persian site map - English site map - Created in 0.03 seconds with 30 queries by YEKTAWEB 4343