[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 26, Issue 5 (11-2021) ::
__Armaghane Danesh__ 2021, 26(5): 744-756 Back to browse issues page
Evaluation of Gallic Acid Effect on Perphenazine Induced Catatonia in Rats Evaluating the Effect of Gallic Acid on
GH Houshmand1 , J Nikbakht 2, M Mahmoudi1 , S Assadpour , A Arab Firozjae1, AA Arimi1 , E Almasian1
1- Department of Pharmacology, Mazandaran University of Medical Sciences, Sari, Iran
2- , jafar_nikbkht@yahoo.com
Abstract:   (384 Views)
Background & aim: Catatonia is one of the major signs of Parkinson’s disease which is due to impaired dopamine in extrapyramidal system. This study was performedconducted to elucidate the role of Gallic acid (GA) on perphenazine (PPZ)-induced catatonia in rat.
 
Methods: This is an experimental study conducted in 2019,48 Wistar male rats weighting 180-220 g were randomly divided into 6 groups (n=8) in each group. Animals were pre-treated with a single dose of normal saline (5ml/kg), most effective dose of bromocriptine (30mg/kg) and GA (100, 200, 400 and 600 mg/kg) via intraperitoneal (IP) route. PPZ (5 mg/kg, IP) was administered after 30 minutes of first injection to induce catatonia. The scoring method of Morpurgo was used to determine the muscular rigidity of animals.
 
Ethical consideration: This study obtained its ethical approval form the Research Ethics Committee. (Code: IR.MAZUMS.RIB.REC.1398.056).
Results: The results indicated that the 100mg/kg GA treated group had no significant reduction in catatonic responses after PPZ administration in comparison with negative control group while the groups that received 400 and 600mg/kg of GA showed significant difference (p<0.05) at all the time points.
 
Conclusion: The results revealed that GA had protective effect on catatonia induced by PPZ in rats. Hence, GA may probably be supportive for reducing catatonia in Parkinsonism. 
 
 
Keywords: Gallic acid, Perphenazine, Catatonia, Rat
Full-Text [PDF 851 kb]   (83 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2021/04/21 | Accepted: 2021/10/18 | Published: 2021/11/8
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Houshmand G, Nikbakht J, Mahmoudi M, Assadpour S, Arab Firozjae A, Arimi A et al . Evaluation of Gallic Acid Effect on Perphenazine Induced Catatonia in Rats Evaluating the Effect of Gallic Acid on. ارمغان دانش. 2021; 26 (5) :744-756
URL: http://armaghanj.yums.ac.ir/article-1-3066-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 26, Issue 5 (11-2021) Back to browse issues page
ارمغان دانش Armaghane Danesh
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4410