1- Department of Biology, Islamic Azad university, Hamedan Branch, Hamedan, Iran, 2- Department of Parasitology, Islamic Azad university, Hamedan Branch, Hamedan, Iran , hossein_vazini@yahoo.com 3- Department of Biology, Bu Ali Sina University, Hamedan, Iran
Methods: In this study 36 male Wistar rats weighing 220±250g were randomly divided into six groups: control group, toxicant group received 0.5g/L lead acetate in tap water, treatment groups (1,2 and 3: received 0.5gr/L lead acetate in tap water and 200,400,800 mg/kg TPE ) respectively. positive control received 400mg/kg TPE gavaged . At the end of examination the blood samples were collected and liver enzymes, total protein, albumin, MDA, total bilirubin and direct bilirubin were analyzed. The data were analyzed by SPSS software and one-way ANOVA and Tukey´s test.
Results: Serum levels of liver enzymes (AST, ALT, ALP) increased significantly in the acetate group compared with the control group (P<0.001).The serum levels of albumin and total proteins were reduced and MDA was increased significantly compared with control group (P<0.001). The serum levels of liver enzymes were reduced significantly in treatment groups compared with toxicant group (P≤0.001).
Conclusion: The effective ingredients in Tragopogon pratensis extract are probably due to the presence of antioxidant compounds reduce the production of released radicals which can stabilize the membrane of the hepatocyte membrane and reduce the release of liver enzymes in the blood.
Hoseini A, Vazini H, Mirazi N. The Protective effect of Hydro-Ethanolic Extract of Tragopogon Pratensis Leaves on Liver of Male Rats Receiving Lead Acetate . armaghanj 2017; 22 (1) :129-144 URL: http://armaghanj.yums.ac.ir/article-1-1628-en.html