[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 14, Issue 4 (1-2010) ::
__Armaghane Danesh__ 2010, 14(4): 23-30 Back to browse issues page
Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats
E HOssini 1, H Sadeghi, A Daneshi
1- , Ebrahim.hossini@yahoo.com
Abstract:   (3898 Views)
Introduction & Objectives: Peganum harmala from the Jigo Phalluses family has compounds such as: alkaloid,saponine steroid and lignin which is used as a traditional medicine witht antibacterial, anti tumor, inhibition of MAO enzyme, and stimulation of the nerve system. It also serves as a modulator to endocrine activities. The aim of the present study was to evaluate the effect of the hydro-alcoholic extract of Peganum harmala on plasma levels of pituitary-thyroid’s hormones of adult rats. Materials & Methods: In this experimental study, which was conducted at Yasuj University of Medical sciences in 2009, 50 adult Mala rats with the approximate weight of 260+30 grams were divided into 5 groups: the control group, the sham group, and 3 experimental groups. The control group did not take any medicine. The sham group received 1 mL of distilled water daily for 17 consecutive days. The experimental groups took 90 mg/kg, 180mg/kg, or 270 mg/kg of Peganum harmala extract daily respectively for 17 consecutive days. In the 18th day, by collecting the blood samples of the animals, plasma level of TSH, T4, and T3 was measured using radioimmunoassay method. Collected data were analyzed using SPSS software. Results: This study revealed that the minimum and maximum dose of the Peganum harmala extract reduces the TSH level and average and maximum dose of the extract significantly reduces the level of T4 and T3 in rats. Conclusion: results of this study indicate that by further study the Peganum harmala extract might be used for treatment hyperthyroidism. However further study is needed to explore this concept.
Keywords: TSH, T4, T3, Peganum Harmala
Full-Text [PDF 117 kb]   (2838 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/05/26 | Accepted: 2015/05/26 | Published: 2015/05/26
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

HOssini E, Sadeghi H, Daneshi A. Evaluation of Hydro-alcoholic Extract of Peganum harmala on Pituitary-thyroid Hormones in Adult Male Rats. Armaghane danesh. 2010; 14 (4) :23-30
URL: http://armaghanj.yums.ac.ir/article-1-579-en.html


Volume 14, Issue 4 (1-2010) Back to browse issues page
ارمغان دانش Armaghane danesh
Persian site map - English site map - Created in 0.03 seconds with 29 queries by YEKTAWEB 4312