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Abstract                
Background & aim: Heart disease is a major cause of mortality in elderly people, and oxidative stress and inflammation lead to changes in myocardium, resulting in apoptosis and cardiac hypertrophy. Accordingly, this study aimed to investigate the effect of 8 weeks of regular aerobic training along with garlic extract consumption on SOD, MDA, CAT, IL-10, and TNF-α levels in the heart tissue of elderly rats with chronic kidney disease.
 
Methods: In the present experimental study, 42 elderly male Wistar rats (48 to 50 weeks old) were selected and randomly assigned to(1) control, (2)Doxorubicin, (3)Doxorubicin-Saline, (4)Doxorubicin-Training, (5) Doxorubicin-Garlic, and (6) Doxorubicin-Garlic-Training (Combination) groups. Chronic kidney disease was induced with a subcutaneous injection of doxorubicin (8.5 mg/kg). The training program included swimming for eight weeks, three days a week, and thirty minutes per day. Doxorubicin-garlic and combination groups were gavaged with garlic extract (2.5 g /kg body weight). One-way ANOVA was used to analyze the data(p<0.05).
 
Results: The results showed that eight weeks of swimming exercise and garlic extract consumption and combination of exercise and garlic significantly increased SOD, CAT and IL-10 levels and also a significant decrease in MDA and TNF-α levels of cardiac tissue of elderly rats with chronic kidney disease, but The highest effect was associated with exercise and exercise(p<0.05).
 
Conclusion: Results indicated that eight weeks of swimming exercise and garlic extract consumption and combination of exercise and garlic significantly increased SOD, CAT and IL-10 levels as well as significant decrease in MDA and TNF-α levels of cardiac tissue of elderly rats with chronic kidney disease. But the greatest effect was the combination of exercise and walking (p<0.05).