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Showing 4 results for Prednisolone
Sm Jazayeri Shooshtari , R Hafezi , S Azizi , A Amanolahi , Volume 13, Issue 1 (4-2008)
Abstract
ABSTRACT:
Introduction & Objective: A standard treatment option for carpal tunnel syndrome (CTS) is local injection of anesthetic-corticosteroid. This clinical trial was designed to compare the safety and efficacy of daily application of the EMLA cream with that of a single injection of methyl prednisolone acetate.
Materials & Methods: This is a clinical trial which was performed in the clinics of Shiraz medical school in 1386. Sixty five participants with clinical and electrodiagnostic evidence of mild to moderate CTS were randomized to receive either the EMLA cream (group 1) or one injection (40 mg) of methylprednisolone acetate at wrist (group 2). Visual analog scale was used to assess the patients’ pain acuity. Collected data were statistically analyzed by SPSS software using Chi-Square test.
Results: Pain intensity before and after treatment and also 4 weeks after treatment in group A was 5.8±0.98 , 0.7±0.82 and 2.1± 1.2 and 5.7 ±1, 2.4±1.5 and 1.6±1.4 in group B. The differences in pain intensity in both group were significant (p<0.001).
Conclusion: EMLA cream was effective in reducing pain associated with CTS. It can be an effective, noninvasive symptomatic treatment for the patients with mild to moderate CTS.
Mj Hadianfard , A Rahimi Jaberi, Sh Kazemilar, Volume 16, Issue 2 (6-2011)
Abstract
Introduction & Objective: Most adults have surely once experienced a headache. A high percentage of these headaches are the referred pain from cervical structures, such as neck muscles, known as cervicogenic headaches. This study aimed to assess the efficacy of injection of methylprednisolone acetate at the Gallbladder-20 acupuncture points in muscle originated chronic and drug resistant headaches.
Materials & Methods: In this randomized clinical trial study conducted at Shiraz University of Medical Sciences in 2009-2010, 25 patients with both chronic and drug resistant cervicogenic headaches, who had cervical muscle tender points, underwent methylprednisolone acetate injection. To evaluate the severity of these patients' headache, VAS (Visual Analogue Scale) was used. The collected data was analyzed using the SPSS software and Wilcoxon test.
Results: The Mean headache intensity on the visual scale of these people before the injection was 3 .2 ± 76.7. This value was 2.60±2.9, 3 days after injection. The values at 1 and 3 months post procedure were 3.52±3.3, and 3.48±3.5, respectively. In other words, a statistically significant loss of pain score (P<0.001) was observed. The frequency of headache attacks 1 and 3 months after injection decreased 72% and 76% among patients, respectively. Average duration of headache attacks, one month and three months after injection, was decreased in 72 percent of patients.
Conclusion: Injection of methylprednisolone acetate at the GB-20acu points in muscle originated cervicogenic headache could be used as an appropriate therapy that has significant therapeutic efficacies only when injected once.
P Yazdan Panah, Hr Ghafarian Shirazi, E Yaghobi, M Akhlagh, Volume 20, Issue 12 (3-2016)
Abstract
Background & aim: Carpal tunnel syndrome is the entrapment of the median nerve in carpal tunnel of the wrist. Symptoms of this syndrome are numbness, tingling, weakness or pain in the fingers and wrist. Treatment includes rest, avoiding the many activities available, splints, non-steroidal anti-inflammatory drugs, oral steroids, steroid injection in wrist and surgery. This study compared the effects of oral prednisolone and naproxen (non-steroidal anti-inflammatory drugs) in the treatment of mild to moderate carpal tunnel syndrome.
Methods: In the present clinical-trial study, 44 patients who had mild to moderate carpal tunnel syndrome were selected and randomly assigned into two treatment groups: group 1(n = 22) received naproxen 1000 mg daily for 4 weeks and the group 2 (n = 22) received oral prednisolone 20 mg, daily, in the first 2 weeks and 10 mg daily for 2 weeks. The 3 persons of the second group dropped out of treatment. Re-evaluation of treatment outcome was performed 2 months later. Collected data were analyzed using SPSS software. To describe the data, frequency tables were used. Furthermore, the Chi-square test was used to analyze the data.
Results: 36(87.8%) of the patients were males and 12.2% were females. The electro diagnostic studies were shown 16 hands (19.5%) normal, 19 hands (23.2%) had mild and 47 (57.3%) had moderate involvement in beginning of treatment. Tingling fingers and pain in the prednisolone group had significantly lower rate than naproxen group (p< 0.05), but the symptoms were not significantly different in the two groups.
Conclusion: The effects of treatments, relief of symptoms and the decrease intensity of carpal tunnel syndrome in patients who received prednisolone were more than naproxen.
E Shaftaloud , Sm Abtahi Froushani, N Delirezh , Volume 24, Issue 1 (4-2019)
Abstract
Background & aim: The anti-inflammatory effects of cabergoline have been documented in various studies. The purpose of the present study was to evaluate the effects of cabergoline administration (as a potent D2 agonist) on clinical aspects and immune responses in rheumatoid arthritis (RA) induced in Wistar rats.
Methods: In the present experimental study, the population consisted of 40 male Wistar rats with a weight range of 160 to 180 g. Animals were randomly allocated into four groups of 10, including the control group (healthy), RA group treated with PBS (100 mg/kg orally), RA group treated with cabergoline (50 µg/kg-orally) and ultimately RA group treated with Prednisolone (10 mg/kg orally). Changes in severity of disease and changes in temperature were recorded every three days. All treatments were initiated at day 7, after induction and observation of the first symptoms of foot inflammation in all rats. Finally, the serum of rats was isolated to evaluate the levels of nitric oxide (Griess assay) and myeloperoxidase (evaluation of the ability to the reduction of hydrogen peroxide). Spleen cells were isolated in sterile conditions in order to evaluate the lymphocyte proliferation rate (MTT reduction assay), the intensity of the respiratory burst (NBT reduction assay), and the potential of neutral red phagocytosis. Data were analyzed using Kruskal-Wallis statistical tests and one-way ANOVA and Tukey tests.
Results: The cabergoline drug was similar to prednisolone, which led to a reduction in the severity of the disease and the swelling of soles of the feet (p=0.15). The serum levels of nitric oxide (p=0.0001) and myeloperoxidase (p=0.0001), the intensity of the respiratory burst of splenic phagocytic cells (p=0.002) and the proliferation rate of splenic lymphocytes (p=0.02) were significantly decreased in both treatment groups. Prednisolone indicated a more profound effect than cabergoline in reducing the lymphocyte proliferative index (p=0.001), while cabergoline effectively reduced respiratory burst activity (p=0.002). Moreover, cabergoline significantly revealed a more profound effect than prednisolone in reducing the increased levels of neutral red uptake by splenic phagocytic cells (p=0.01).
Conclusion: Considering the appropriate results in the animal model, the use of cabergoline may be considered as a useful approach to control RA.
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