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Backgrounds & aim: Wheezing after bronchiolitis is known as a risk factor for asthma. No cure or effective vaccine has been identified for such disease. The purpose of this study was to determine the effects of zinc sulfate on persistent wheezing after bronchiolitis in infants less than two years. Methods: The present randomized clinical trial study was conducted on 90 infants under two years of age suffering from the first attack with a clinical diagnosis of bronchiolitis wheezing hospitalized in Imam Sajjad Hospital, Yasuj. All infants were equally placed in test groups and control group. In addition to bronchiolitis usual treatment, test group received 20 mg of elemental zinc for seven days. Patient information including risk factors associated with wheezing and persistent wheezing were compared 48 hours and two weeks after treatment. Data were analyzed using chi-square and t tests. Results: In all 90 infants diagnosed with bronchiolitis, wheezing was observed. After 48 hours and two weeks wheezing was continued in 67 patients (74.4%) and 54 patients (60%) respectively Conclusion: The results showed Zinc sulfate had no effect on the improvement of wheezing after bronchiolitis.

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Background & aim: Viral bronchiolitis is one of the most common causeS of lower respiratory tract infection and almost responsible for 1-3% of hospitalization among children under one year of age. Post bronchiolitis wheezing is the main risk factor for childhood asthma, and its control can decrease incidence of the disease in future. The purpose of this study was to investigate the effect of vitamin A on persistent wheezing after bronchiolitis. Methods: The present double blind clinical trial was conducted on 84 patients aged 1 to 12 months of age who were admitted in Imam Sajad Hospital of Yasuj from October 2012 to 2013. After viral bronchiolitis diagnosis of patients with history and physical exam, they were divided into two similar groups of control and case randomly. Control group received cold and wet nebulized oxygen and bronchodilator and case group received the same protocol together with 5000 IU/kg Vitamin A intramascularlly. Both groups were examined by the same physician before, one and two weeks after treatment and quality and severity of wheezing was recorded. Data were analyzed by statistical student T – test and chi square test. Results: Intensity and quality of wheezing was similar in both groups before the intervention(85/0 = p=0.858) whereas a significant reduction was observed in the severity of wheezing in the group receiving vitamin A compared with the control group (05/0> p<0.05). Conclusion: A significant decrease was observed in persistent wheezing after intramascular administration of a dose of vitamin A in patients requiring hospitalization due to viral bronchiolitis. Administrating one dose vitamin A intramuscularly in patients who need hospitalization due to bronchiolitis, may decrease post bronchiolitis and persistent wheezing.