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Background & aim: One of the appropriate ways to control overweight and obesity is regular training and the benefit of antioxidant supplements. The purpose of the present study was to investigate the effect of eight weeks of Circuit resistance training and spirulina supplementation on plasma levels of Irisin and some body composition indices in overweight and obese men.
 
Methods: The present single blind quasi-experimental study with double blind method, 60 overweight and obese men (BMI>25) aged 30-55 years were purposefully selected and randomly divided into four groups: training + Spirulina, training + placebo, spirulina, and placebo. The intervention and placebo groups consumed two 500-mg capsules of spirulina and placebo for eight weeks, respectively. Resistance training was performed for eight weeks, three sessions a week, and 12 movements as: very light, light, medium and heavy intensities with rest intervals (actively) between stations and shifts of 1, 1-2 and 3-5 minutes were administered. Body composition indices, body weight, BMI, and WHR were measured before and after training using a combination gauge. Subjects were fasted for 12 hours in two stages (pre- and post-test) of 10 ml blood from antecubital left bra vein. The data were analyzed using Shapiro-Wilk tests, one-way ANOVA, LSD and t-test at (α<0.05).
 
Results: Plasma levels of irisin and body weight indicated a significant difference between groups (p<0.05). In the intergroup study, the plasma levels of irisin in the training+spirulina, training+ placebo groups increased significantly(p<0.05), but body weight, BMI in the training+ spirulina, training+placebo and spirulina groups, and WHR values in the training+Spirulina, training+ placebo decreased significantly(p<0.05). Plasma levels of irisin, body weight, BMI and WHR in the placebo group did not change significantly(p>0.05).
 
Conclusion: It seemed that eight weeks of Circuit resistance training with spirulina by increasing plasma levels of Irisin and reducing body weight, BMI, and WHR supplementation significantly improved the body composition and obesity-related disorders.