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Showing 16 results for Insulin Resistance
A Mohammadi Domiyeh , A Khajehlandi,
Volume 17, Issue 5 (12-2012)
Abstract
Abstract
Background & aim: Lipocalin-2 is a novel adipokine which is highly expressed in adipose tissue s that closely link with obesity, insulin resistance and type 2 diabetes. The aim thus the purpose of this study was to examine the effect of eight weeks of resistance versus endurance training on lipocalin-2 levels in non-athlete male students.
Methods: In this clinical trial study, 30 healthy male students were selected and divided in to three groups such as: controlincluding control group, resistance and endurance training groups.
Resistance training performed 3 three d/wk at an intensity corresponding to 65–80% of one-repetition maximum, 8-12 repetitions and 2-4 sets for 8 weeks. Endurance training group, underwent an 8-week intervention with a frequency of 3 d/wk at an intensity corresponding to 65, – 80% maximum heart rate for 20- – 38 minutes. Expressing lipocalin-2 plasma levels in samples were measured before and after intervention. Data were analyzed by one-way ANOVA.
Results: Plasma expressing level of lipocalin 2 in the control group before and after intervention, were respectively 11./1 ± 4./5 & 13./05 ± 2/.04, µg/L, respectively. The plasma level of lipocalin 2 and in the endurance training group, were 22./7 ± 8/.3 & and 17/.7 ± 6/.8 , and while these level werein the resistance training group 22/.2 ± 6/.2 & 19/.9 ± 6/.5 in the resistance training group. micrograms per liter, which was not statistically different.The differences between three groups were not statistically significant (p>0/.05).
Conclusion: This study showed that 8 eight weeks of endurance & and resistance exercise training has no effect on lipocalin-2 plasma levels.
Key words: Resistance training, Endurance training, Lipocalin-2, Insulin Resistance
Sa Hosseini , H Nik Bakht , Ma Azarbayjani,
Volume 18, Issue 4 (8-2013)
Abstract
Abstract
Background & aim: According to the proven effectiveness of saffron resistance and physical activity on diabetes, the aim of this study was to evaluate the effect of glycemic indexes of saffron combined with resistance training on streptozotocin induced diabetic rats.
Methods: The present experimental study was conducted on 36 adult male rats. After induction of diabetes, the rats were randomly divided into four equal groups, resistance exercise (five days a week, for six days) and saffron extract (25 mg/L daily), resistance exercise combined with saffron extract and control groups. After a period of six weeks, glycemic indexes were measured. The gathered data were analyzed by klomogrov – Smirnov, one-way ANOVA and Tukey tests.
Results: The results showed that fasting glucose in saffron aqua extract combined with resistance training group was significantly lower than both control and the RT groups ( p=0,014). Glycosylated hemoglobin group of saffron combined with resistance training was lower than the control group (p=0.011). Insulin resistance combined with resistance training in saffron aqua extract was lower than the control group (p=0.011).
Conclusion: Six weeks of resistance training and consumption of saffron alone had a significant effect on glycemic indexes. However, saffron supplements with resistance training had a greater effect on control of fasting blood glucose.
Key words: resistance training, saffron, glucose, HbA1C, insulin resistance, diabetes
Mt Afshon Pour, Ah Habibi, Ra Ranjbar,
Volume 21, Issue 1 (4-2016)
Abstract
Background & aim: Apelin is a newly discovered adipokine which plays an important role in regulation of energy homoeostasis and improvement of insulin resistance. The aim of this study was to determine the effect of continuous aerobic exercise on plasma concentration of apelin and insulin resistance in type 2 diabetic men.
Methods: In the present quasi-experimental study, twenty four diabetic men from Ahwaz, Iran, were selected and randomly divided into training (n=12) and control (n=12) group. Anthropometric measures, body composition and maximal oxygen uptake (VO2max) of the subjects were measured by using a modified Bruce continuous aerobic exercise training was performed during 8 week (3 session per week, 20-45 min per session, 40%- 70% HRmax). Before, and 48 hours after the last training session, plasma concentration of glucose, insulin and apelin were measured and HOMA-IR was calculated. Data analysis was used by T-tests, ANOVA and Pearson correlation coefficient and the significant level of p<0/05 was considered.
Results: There was a statistically significant decrease in plasma concentration of glucose and insulin and HOMA-IR, and a significant increase in plasma concentration of apelin was observed in training group compared with pretest and control group. Furthermore, a significant negative relationship between plasma concentration of apelin and HOMA-IR after 8 weeks aerobic training was found.
Conclusion: It seems that low to moderate intensity continuce areobic exercise training has significant effect on the amount of plasma apelin in type 2 diabetic men. Continuous aerobic exercise may be effective in improving the insulin resistance and glycemic control in type 2 diabetic men.
N Kazemi, Mr Kordi, R Noori , M Kasraian,
Volume 21, Issue 3 (6-2016)
Abstract
Background & aim: Gestational diabetes is defined as diagnosing impaired glucose tolerance for the first time during pregnancy. The purpose of the present study was to compare the effect of aerobic and resistance training on fasting blood sugar, insulin and insulin resistance in women with gestational diabetes.
Methods: A total of 34 women with gestational diabetes voluntarily participated in the present Semi- experimental interventional study, which were selected from the available sampling pool. The participants were randomly assigned into 3 groups. 12 participants (age 28/92 ± 3/60 years) participated in an aerobic training group (3 days/week, 30-45 min/day, 50-70%maximum heart rate), 11 participants (age 30/27 ± 4/14 years) participated in a resistance training group (3 days/week, 2-3 set of 15 repetition, 50-70%maximum heart rate and Rating of perceived exertion), and 11 participants (age 29/18 ± 4/23 years) were in control group who did not participate in any exercise program during the study period. Blood samples were collected in the pre-test and post-test to assess the level of blood sugar and insulin. Statistical analysis of covariance was used to compare the groups. The data were analyzed by the SPSS software (ver.23. The significant level was considered p≤0.05.
Results: The results of the present study showed a significant difference in insulin plasma levels (p = 0.031), insulin resistance index (p = 0.008) and insulin sensitivity among groups. T-test results indicated a significant reduction in fasting blood sugar of resistance group (p=0.12) but no increase was observed in the aerobic group. At the levels of insulin, insulin resistance and insulin sensitivity, no significant changes were observed in exercise group.
Conclusion: It was concluded that resistance training compared with aerobic training was more effective in reducing fasting glucose levels in women with gestational diabetes.
fasting blood sugar, insulin, insulin resistance, insulin sensitivity, pregnancy
Dr H Rashidi, Dr M Tafazoli, Dr Mt Jalali ,
Volume 21, Issue 9 (12-2016)
Abstract
Background and aim: Polycystic ovary syndrome is a common endocrine disorder that is associated with lipid disorders and obesity with an increased risk of cardiovascular disease. The aim of this study was to determine the association between lipid profile and fasting blood sugar levels and insulin resistance among women with polycystic ovary syndrome.
Methods: The present case-control study was conducted on 153 women with PCOS and 449 healthy women as controls. Data was extracted from data center of Diabetes Research Center of Ahvaz University of Medical Sciences including women from 4 cities of Khuzestan province (Ahwaz, Behbahan, Abadan, and Khorramshahr). Serum lipids, fasting blood sugar, and serum insulin levels along with Body Mass Index (BMI), Homeostatic Model Assessment Insulin Resistance (HOMA IR), Lipid Accumulation Product (LAP), and Body Adiposity Index in two groups were analyzed by independent t-tests, chi-square and Fisher exact test.
Results: The frequency of low HDL and high total cholesterol was higher in women with PCOS than control group (p =0.032, and p =0.001, respectively). No significant difference was seen between No two groups in the mean levels of total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, fasting blood sugar, HOMA IR, LAP, and PA (p >0.05). In women with BMI<25 and BMI between 25 and 30, the mean level of total cholesterol was higher in PCOS group than control group, whereas there was no significant difference in women with BMI>30. In women with BMI>30, the mean triglyceride and glucose levels was higher in PCOS group than control group (p=0.029, and p=0.010).
Conclusion: In the present study, in obese women, triglyceride and fasting glucose levels were higher in patients with polycystic ovary syndrome than healthy women. In non-obese women, however, the total cholesterol level was higher in patients with polycystic ovary syndrome than healthy women.
M Habibian , P Farzanegi, B Asadi,
Volume 22, Issue 1 (4-2017)
Abstract
ABSTRACT
Background and aim: Childhood obesity is associated with an increased risk of cardiovascular complications and multiple metabolic such as insulin resistance and hyperhomocysteinemia. The aim of this study was to investigate the effect of regular aerobic exercise along with vitamin C consumption on the homocysteine levels and insulin resistance in obese girls.
Methods: In the present semi-experimental study, 28 obese girls aged 8 to 12 years and body mass index 95% were selected and randomly divided as follow: control, exercise training, vitamin C and exercise training+ vitamin C (combined) groups. Aerobic exercise was consisted of exercise movements at 50% to 70% maximal heart rate and 3 sessions per week for 8 weeks. Vitamin C and combined groups consumed 500mg vitamin C tablets every other day. Fasting blood samples were collected before and 48 hour after the last intervention. For statistical analysis, One Way Analysis Variance (ANOVA), post hoc Tukey and independent t-test were used.
Results: Eight weeks of aerobic exercise, vitamin C and the combined intervention were resulted a significant decrease in the levels of glucose, insulin, homocysteine and insulin resistance in obese girls (P<0.05). Furthermore each of three interventions was associated with a significant percent changes in these veraibles compared with control group. But the effect of combined intervention on the decrease in these variables were greater compared with other interventions (p<0.05).
Conclusion: These findings suggested that both of aerobic exercise and vitamin C consumption non-drug can cause down regulation of homocysteine and insulin resistance levels in obese girls. Thus, the combined effect of regular aerobic exercise and vitamin C intervention is associated with the augmentation of these effects.
Z Taghavian , - H Rabiee , - M Faramarzi , - A Azamian,
Volume 22, Issue 2 (6-2017)
Abstract
Background & aim: Chemerin are novel adipokines that are secreted from adipose tissue and improved insulin sensitive. The purpose of this study was to examine the ffects of rhythmic aerobic exercise plus core stability training on serum chemerin levels and Insulin resistance, glucose levels and body composition of overweight women.
Methods: In this quasi-experimental study, 40 healthy women aged 25-45, waist circumference equal to and above 88 cm, body mass index of 3025 kg / m2 were selected and randomly divided into control (n = 16) and experimental (n = 19) groups. ). Five people were excluded from the study. The experimental group was trained 12 weeks (3 sessions per week per session). The exercise program included aerobic exercise (55% -80%), maximum heart rate, and trunk stability training. The pre-test and post-test stages were collected at 12-hour fasting time, blood samples were collected in the same conditions. The ELISA method was used to determine the fasting and low-level insulin levels. Insulin resistance was evaluated based on the evaluation of HOMA-IR model of homeostasis. To compare the pre-test and post-test changes, the dependent t-test was used and the inter-group variations of one-way ANOVA with a significant level (p≤0.05) were used.
Results: Chemerin plasma levels, body mass index, weight, body fat percentage and The ratio of waist circumference to hip In Overweight After 12 weeks Rhythmic aerobic exercise Along with Trunk stability exercises Showed a significant reduction )p≤0/05). But insulin resistance The fasting plasma glucose and Insulin levels between two groups Practice and Control was no significant difference (p>0/05).
Conclusion: Despite the fact that this kind of intervention can be an effective treatment to improve the level of low-fat adipokine and lower body waist circumference, however, a trickier exercise is required to significantly change insulin resistance and glucose levels In women with overweight.
R Soori , Mr Asad, Mr. M Yari , M Rastegar Moghadan Mansouri ,
Volume 22, Issue 3 (8-2017)
Abstract
Background & aim: Obesity as an epidemic which is associated with excessive accumulation of adipose tissue that secretes many hormones such as applein. Applein is an adipocytokine that increases its level in obesity. Changes in the level of apelin in response to aerobic exercise are not well defined. Therefore, the purpose of this study was to determine the effect of eight weeks of sub-maximal aerobic training with intensity of 50 to 60% of maximum heart rate on serum apelin-13 and insulin resistance in overweight men.
Methods: The present study was a quasi-experimental research. A total of 26 male overweight subjects with a body mass index of 27-30 kg / m2 were selected and randomly assigned to the subgroups and control aerobic exercise groups after the request was announced and adjusted to the entrance criteria. The aerobic training group under-maxed rrun out the training program for 30 sessions in an eight-week interval (3 sessions per week with an intensity of 50-70% of maximum heart rate).Body mass index, maximum oxygen consumption and blood sampling were performed and 24 hours after the last training session, the evaluations were repeated. Data were analyzed by statistical tests.
Results: The results of this study showed a significant decrease in body weight and body fat (p <0.05). Also, maximum oxygen consumption was significantly increased (p = 0.0001). However, indices of insulin resistance and Applein 13 did not show any significant changes. In addition, there was a direct and significant correlation between apelin 13 indices with anthropometric indices and glycosylated hemoglobin (p <0.05).
Conclusions: The internal factors of exercise practice, the intensity of aerobic exercise, have a significant effect on the anthropometric characteristics of overweight individuals, but not enough for significant changes in the levels of Applein 13 and insulin resistance. It is recommended that exercises be carried out over a longer period of time and more intensively so that the risk of developing type 2 diabetes and cardiovascular disease in people with overweight is reduced and controlled.
M Ghafari , E Banitalebi, M Faramarzi , A Mohebi ,
Volume 22, Issue 3 (8-2017)
Abstract
Abstract
Background & aim: Lipid metabolism disorder plays an important role in insulin resistance in skeletal muscle and lipid drop proteins such as perlipine 2 (PLIN2) are effective in regulating intracellular fat metabolism. One of the suggested pathways for the effects of endurance activity in metabolic diseases is the effect of physical activity on intramuscular. Therefore, the purpose of this study was compare the intensity of aerobic exercise intensity (low intensity and high intensity) on expression of PLIN2 skeletal muscle, serum glucose and insulin levels in streptozotocin-diabetic rats.
Methods: In this experimental study, 24 male Wistar rats were randomly divided into three groups of 8, including two intervention groups (low intensity endurance training group and high intensity continuous exercise group) and one control group. After induction of diabetic rats by injection streptozotocin (55 mg / kg body weight), Intraperitoneally, endurance training was applied for eight weeks, three sessions per week in diabetic rats. Exercise intensity in the low-intensity group was equal to 5-8 m / min (equivalent to 50-60% Vo2max), the intensity of training in a high intensity training group was equivalent to a speed of 22-25 m / min (equivalent to 80% Vo2max) and the control group did not receive intervene in this time. Relative protein expression of PLIN2 was performed using western blot technique. Data were analyzed by one-way ANOVA and Tukey's post hoc test.
Results: The results of the intergroup comparison revealed a significant difference among three groups in the PLIN2 variables (p = 0.037). The results of post hoc test showed a significant increase in PLIN2 in high intensity training diabetic group compared to the control group (p = 0.033) However, there was no significant difference in PLIN2 level in the low exercise group compared to the control group (p = 0.18). Also, there was no significant difference between the low intensity and high intensity training groups (p = 0.66). Serum glucose and insulin levels were significantly different between diabetic control groups and low intensity and high intensity training (p = 0.001). This difference was between the high intensity training group with low intensity group (p = 0.04, p = 0.01), diabetes control (p = 0.001, p = 0/000), respectively.
Conclusion: Regarding the results of the study, modulation effects of high intensity endurance exercises on increasing the expression of PLIN2 in diabetic specimens were noted.
L Naderi , Gh Sharifi ,
Volume 22, Issue 5 (12-2017)
Abstract
Abstract:
Background & aim: The main aim of the present research is to review and compare the effect of 8 weeks concurrent trainings and consumption of green coffee supplement on the serum level of Adipsin and Insulin Resistance Index and BMI in obese women.
Methods: In this quasi-experimental study, 48 obese women with average age 12.31±8.8, weight 41/9±84 kg and BMI 51.32±49.2 kg/m2 were selected purposefully and divided randomly into four groups of concurrent Trainings (n=12), consumption of Green Coffee Supplement (n=12), concurrent Trainings- Green Coffee Supplement (n=12) and control group (n=12).The concurrent Trainings conducted including 8 weeks aerobic and resistance trainings, three sessions in a weak, each session 70 minutes. Green Coffee Supplement group consumed one 400 mg capsule in a day for 8 weeks. Fasting blood sample were taken from the subjects 24 hours before the first session and 48 hours after the last exercise session to measure serum levels of Adipsin,Glucose and Insulin. Insulin resistance was evaluated based on the evaluation of HOMA-IR model of homeostasis. To compare intra-group changes the dependent t-test was used and the inter-group variations of one-way ANOVA and LSD was used to determine which groups were significantly different.
Results The results of one-way ANOVA demonstrated a significant difference between the data of Adipsin, insulin, insulin resistance and body mass index in concurrent training groups, green coffee supplementation, concurrent exercise and supplementation of green coffee and control group (p<0.005). no significant difference was seen between mean glucose in concurrent training groups, green coffee supplementation, concurrent exercise and green coffee supplementation(P> 0.05). But there is a significant difference between the three groups with the control group. The results of LSD test showed that the mean of adipsin decreased in all three groups after 8 weeks, and the mean of insulin decreased in the training group and increased in other groups. Insulin resistance decreased, but decreased in the combined exercise group. The mean of BMI in the training and supplementation groups was the lowest and in the supplement group was the highest.
Conclusions: Overall, the findings of the present study demonstrated that exercise activity and green coffee by effecting on the adipokine secretion lead to decrease in the adipsin level, reduced insulin resistance and decreased weight. Therefore, obese women can use these exercises and complementary green coffee to lose weight.
H Ghaedi , M Faramarzi, K Ghotra Samani, E Bani Talebi , A Azamian ,
Volume 23, Issue 2 (6-2018)
Abstract
Background & Aim:Fat-Specific Protein 27 (Protein Specialty Protein) is one of the proteins that play a role in the regulation and metabolism of lipid droplets. The aim of this study was to evaluate the effect of endurance training on expression of specific lipid profile (FSP27) and insulin resistance in STZ-diabetic rats.
Methods: In this experimental study, 40 male Wistar rats were divided into five groups (diabetic group), low intensity endurance training (DLE), diabetic group, moderate intensity exercise (DME), diabetic group, and endurance training with intensity High (DHE), control group of diabetic (DC) and healthy control (HC). After diabetic administration, streptozotocin was injected with endurance training with low, moderate and high intensity for eight weeks, three sessions per week and each session for 30 minutes. Serum glucose levels were measured by glucometer, insulin with mouse specific ELISA kit, relative expression of FSP27 protein with Western Blot method and insulin resistance index. One-way analysis of variance and Tukey and James Howell post hoc tests were used to determine the difference between groups.
Results: The results showed that endurance training with three severity (low, moderate and high) had a significant effect on serum glucose, insulin and insulin resistance values (p = 0.001). Reductions in serum salivary and glucose levels were significant in high intensity exercise groups and moderate intensity exercises versus diabetic control and low intensity exercise (p≤0.05). Insulin resistance values were significantly higher in moderate and high intensity training groups compared to low exercise group, diabetic control group and healthy control group (p≤0.05). The expression of FSP27 protein in endurance training groups with three intensities with diabetic control and healthy control was not significantly different. However, the results showed that the content of FSP27 in the training groups increased with intensity of exercise compared to the diabetic control group (the value of p was exactly noche, not approximation)
Conclusion: Although, none of the endurance training interventions produced a significant difference in FSP27. Considering the tendency to increase FSP27 with increasing endurance training, it seems that endurance training with an appropriate intensity can be achieved by increasing FSP27 and subsequent reduction of the acids Free fat on the one hand and increased glucose uptake, on the other hand, increase insulin sensitivity and improve insulin resistance in diabetic rats.
K Derakhshan , A Mohammadi, A Khajeh Landi,
Volume 23, Issue 2 (6-2018)
Abstract
Background and Aim: Diabetes is known as the most common metabolic endocrine disorder that causes debilitating complications of the eye, renal, neurological and cardiac diseases, and has irreparable biological, psychological, social and economic consequences. The aim of this study was to determine the effect of water exercise on glycosylated hemoglobin and C-reactive protein in type 2 diabetic women.
Methods: In this semi-experimental study, 30 type II diabetic women were selected and randomly assigned to either control (n = 15) or control (n = 15). The experimental group performed 8 sessions per week for 3 sessions and 60-70 minutes each exercise protocol in the cramped pool. During this study, no intervention was performed on the control group. Data were analyzed for the comparison of intra-group of correlated T-test and inter-group comparison of independent t-test (p<0.05).
Results: The result showed that the exercise in water in the experimental group, body mass index (p <0.015), waist to hip ratio (p <0.022) and body fat percentage (p> 0.04) significantly decreased. Also, the results of independent t test showed that HOMA-IR (P=0.013), CRP (P=0.001), HbA1C (P=0.001), significantly decreased in experimental group compared with control group.
Conclusion: It can be suggested that eight weeks of exercise in water by decreasing anthropometric indices, CRP levels, glycosylated hemoglobin, and insulin resistance index can prevent type 2 diabetes and its metabolic complications.
M Dayani , F Taghian,
Volume 23, Issue 4 (10-2018)
Abstract
Abstract
Background and Aim: Visfatin is an insulin-like protein derived from adipose tissue that is associated with obesity and insulin resistance. The purpose of this study was to compare the effects of 12 weeks of combined exercises and vitamin D on the serum visfatin level and beta cell function in women with overweight type II diabetes.
Methods: 40 type 2 diabetic women with a mean age of 1.49 ± 3.65 years, weight 158.15 ± 5.65 cm and body weight index 29.4 ± 0.46 kg / m2 were selected purposefully The groups were randomly divided into four groups of 10, three experimental groups (combined exercise, vitamin D, combined exercise with vitamin D) and control group. Height, weight, BMI and fat percentage of subjects were measured. After 12 hours of fasting, the primary blood sample was taken to measure glucose, insulin, visfatin, insulin resistance, and beta cell function. Subjects then participated in the experimental group 1 in the combined program. The experimental group, in addition to the combined exercises, consumed vitamin D 6 pills per 50,000 units a week. Experimental group 3 consumed only vitamin D with 6 pills per dose of 50,000 units per week and did not have any training. The control group was only tracked. After 12 weeks, all variables were re-measured in 4 groups. Data were analyzed using covariance analysis (ANCOVA) at the level of p <0.05.
Results: The mean values of post glucose, insulin, insulin resistance, beta cell and visfatin function were significantly different between the four groups with control of pre-test values of these variables (0.001> p). In the case of insulin, there was no significant difference between the mean values of insulin levels in vitamin D, exercise and combination therapy and vitamin D (p <0.05). There was no significant difference in insulin resistance between the mean resistance to insulin in the control and vitamin D groups (p> 0.05). There was no significant difference in the performance of beta cells between the mean values of performance in control, exercise and exercise groups and vitamin D (p <0.05). In the case of visfatin, the mean values of visfatin in the treatment group and vitamin D were significantly less than the other three groups (p <0.05).
Conclusion: The findings of this study indicate the effect of combined exercises and vitamin D intake on visfatin levels in overweight diabetic women.
G Taheri , M Fathi , E Mir,
Volume 24, Issue 3 (7-2019)
Abstract
1.Oliveira A, Monteiro A, Jácome C, Afreixo V, Marques A. Effects of group sports on health-related physical fitness of overweight youth: a systematic review and meta-analysis. Scandinavian Journal Of Medicine & Science In Sports 2017; 27(6): 604-11. ##
2.Bray GA. Fructose: should we worry? International Journal of Obesity 2009; 32(S7): S127. ##
3.Bilski J, Teległów A, Zahradnik-bilska J, Dembiński A, Warzecha Z. Effects of exercise on appetite and food intake regulation. Medicina Sportiva 2009; 13(2): 82-94. ##
4.Shabani M, Mohammad-Zadeh M, Azhdari-Zarmehri H. Orexin (hypocretin): a multi-functional hypothalamic peptide. Koomesh 2014;15(3): 275-81. ##
5.Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and g protein-coupled receptors that regulate feeding behavior. Cell 1998; 92(4): 573-85. ##
6.Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978; 14(3): 141-8. ##
7.Kirchgessner AL. Orexins in the brain-gut axis. Endocrine Reviews 2002; 23(1): 1-15. ##
8.Chemelli RM, Willie JT, Sinton CM, Elmquist JK, scammell T, lee C, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999; 98(4): 437-51. ##
9.Salehi Omran MT, Jafari S. Association of admission insulin resistance index with early cardiac complications in non diabetic patients with acute coronary syndrome. Journal of Babol University of Medical Sciences(Jbums) 2009; 6(47): 62-6. ##
10.Defronzo RA. Pathogenesis of type 2 diabetes mellitus. Medical clinics 2004; 88(4): 787-835. ##
11.Skrzypski M, le T, Kaczmarek P, Pruszynska-Oszmalek E, Pietrzak P, Szczepankiewicz D, et al. Orexin a stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3t3-l1 adipocytes and isolated primary rat adipocytes. Diabetologia 2011; 54(7): 1841-52. ##
12.Miyasaka K, Masuda M, Kanai S, Sato N, Kurosawa M, Funakoshi A. Central orexin-a stimulates pancreatic exocrine secretion via the vagus. Pancreas 2002; 25(4): 400-4. ##
13.Matsumura K, Tsuchihashi T, Abe I. Central orexin-a augments sympathoadrenal outflow in conscious rabbits. Hypertension 2001; 37(6): 1382-7. ##
14.Martynska l, Wolinska-witort E, Chmielowska M, Bik W, Baranowska B. The physiological role of orexins. Neuro Endocrinology Letters 2005; 26(4): 289-92. ##
15.Abaassi daluee A, Ghanbari niaki A, Fathi R, Hedayati M. The effect of a single session aerobic exercise on plasma ghrelin, gh, insulin and cortisol in non-athlete university male students. Iranian Journal of Endocrinology and Metabolism 2011; 13(2): 197-201. ##
16.Bagheri Nia M, Abedi B. Effect of eight weeks of pilates training on orexin and insulin resistance levels in overweight children. Yafteh 2018; 1(75): E00109. ##
17.Haskell-luevano C, Schaub JW, Andreasen A, Haskell KR, Moore MC, Koerper IM, et al. Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. The Faseb Journal 2009; 23(2): 642-55. ##
18.Mir E, Fathei M, Sayeedi MM, Hejazi K. The effect of eight weeks combined training (aerobic-resistance) on homocysteine, c-reactive protein and lipid profile in inactive elderly men. Medical Journal of Tabriz University of Medical Sciences & Health Services 2015; 36(6): 80-6. ##
19.Abdolmaleki Z, Saleh SB, Bahram A, Abdolmaleki F. Validity and reliability of the physical self-description questionnaire among adolescent girls. Journal of Applied Psychology 2011; 4(16): 42-55. ##
20.Bonora E, Formentini G, Calcaterra F, Lombardi S, Marini F, Zenari L, et al. Homa-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the verona diabetes complications study. Diabetes Care 2002; 25(7): 1135-41. ##
21.Alizadeh AA, Rahmani-nia F, Mohebbi H, Zakerkish M. Effects of eight weeks aerobic exercise on plasma levels of orexin a, leptin, glucose, insulin, and insulin resistance in males with type 2 diabetes. Iranian Journal of Diabetes and Obesity 2015; 7(2): 62-8. ##
22.James MH, Campbell EJ, walker FR, Smith DW, Richardson HN, Hodgson DM, et al. Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats. Frontiers in Behavioral Neuroscience 2014; 8: 244. . ##
23.Wu H, Xia FZ, Xu H, Zhai H, Zhang MF, Zhang HX, et al. Acute effects of different glycemic index diets on serum motilin, orexin and neuropeptide y concentrations in healthy individuals. Neuropeptides 2012; 46(3): 113-8. . ##
24.Ouedraogo R, Näslund E, Kirchgessner AL. Glucose regulates the release of orexin-a from the endocrine pancreas. Diabetes 2003; 52(1): 111-7. . ##
25.Wu T, Gao X, Chen M, Van Dam R. Long-term effectiveness of diet-plus-exercise interventions vs. Diet-only interventions for weight loss: a meta-analysis. Obesity Reviews 2009; 10(3): 313-23. . ##
26.O'neill HM. Ampk and exercise: glucose uptake and insulin sensitivity. Diabetes & metabolism Journal 2013; 37(1): 1-21. . ##
27.Messina G, Di bernardo G, Messina A, Dalia C, Chieffi S, Galderisi U, et al. Brief exercise enhances blood hypocretin-1 in sedentary men. Journal of Sports Medicine & Doping Studies 2014; 4: 149. . ##
28.Butterick TA, Billington CJ, Kotz CM, Nixon JP. Orexin: pathways to obesity resistance? Reviews in Endocrine and Metabolic Disorders 2013; 14(4): 357-64. . ##
29.Sundarrajan L, Unniappan S. Small interfering RNA mediated knockdown of irisin suppresses food intake and modulates appetite regulatory peptides in zebrafish. General and comparative endocrinology. 2017;252:200-8. . ##
30.Bijeh N, Hejazi K. The effect of aerobic exercise on levels of HS-CRP, insulin resistance index and lipid profile in untrained middle-aged women. Razi Journal of Medical Sciences. 2018 Jan 15;24(10):1-1. . ##
31.Ho SS, Dhaliwal SS, Hills AP, Pal S. The effect of 12 weeks of aerobic, resistance or combination exercise training on cardiovascular risk factors in the overweight and obese in a randomized trial. Bmc Public Health 2012; 12(1): 704. . ##
32.Saremi A, Shavandi N, Mohammadpour K. Effects of 8 weeks aerobic training with omega-3 supplementation on inflammatory responses in type 2 diabetic patients. Payesh 2015; 14: 1. . ##
33.Oki K, Yamane K, Kamei N, Nojima H, Kohno N. Circulating visfatin level is correlated with inflammation, but not with insulin resistance. Clinical Endocrinology 2007; 67(5): 796-800. . ##
34.Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. Jama 1999; 281(18): 1722-7. . ##
35.Church TS, Barlow CE, Earnest CP, Kampert JB, Priest EL, Blair SN. Associations between cardiorespiratory fitness and c-reactive protein in men. Arteriosclerosis, Thrombosis, and Vascular Biology 2002; 22(11): 1869-76. . ##
36.Christopherson J, Sumer V, Kirkendall D, Jones MA. Effects of exercise detraining on lipid storage in rats. Transactions of the Iillinois State Academy of Science 1999; 92(3): 203-9.
37.Kodama S, Miao S, Yamada N, Sone H. Exercise training for ameliorating cardiovascular risk factors-focusing on exercise intensity and amount. International Journal of Sport and Health Science 2006; 4(2): 325-38. . ##
38.Hosseini k, Attarnejad Z, hosseini HA. A comparison of the effects of two aquatic exercise sessions with different duration on adiponectin and insulin resistance in women with type 2 diabetes. Journal of Sabzevar University of Medical Sciences 2014; 20: 4. . ##
39.Kadoglou NP, Vrabas IS, Kapelouzou A, Lampropoulos S, Sailer N, Kostakis A, et al. The impact of aerobic exercise training on novel adipokines, apelin and ghrelin, in patients with type 2 diabetes. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 2012; 18(5): cr290. . ##
 Armaghane-danesh, Yasuj University of Original Article
Medical Sciences Journal (YUMSJ)
Changes in Orexin A Serum Level, Insulin Resistance and Anthropometric Indices in Overweight Women after Six Weeks of Aerobic Training
Taheri G1, Fathi M2*, Mir E2
[1]Department of Sport Physiology, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran, 2 Department of Sport Physiology, Ferdowsi University of Mashhad, Mashhad, Iran
Received: 10 Dec 2018 Accepted: 12 May 2019
Abstract
Background & aim: Orexin is an orexigenic peptide present in the form of A and B in the blood. Orexin neurons respond to a number of metabolic signals that indicate the body's energy status. The present study was carried out to evaluate the effect of six weeks of aerobic training on orexin level, insulin resistance and anthropometric indices in overweight women.
Methods: In the present quasi-experimental study, the statistical population consisted of overweight and inactive women in Bojnourd, Iran,, aged 45-65 years, and BMI 26-29 kg/m2. Twenty-four eligible individuals were randomly divided into two groups of control and exercise. The exercise included aerobic training (with intensity of 60-70% of maximum heart rate reserve). The exercise performed three times per week for six weeks.
Results: The six weeks of aerobic training increased the orexin A level and decreased insulin, glucose, insulin resistance index, weight, BMI, WHR and fat percentage in interventional group. But in control group none of these variables changed significantly after six weeks(P<0.05).
Conclusion: The six weeks of aerobic training increased the orexin A level, decreased insulin resistance and improves anthropometric indices in overweight women. Therefore, obese women are recommended to use these exercises as a preventive method for future diabetes and cardiovascular diseases.
E Moslehi, V Minasian, H Sadeghi ,
Volume 25, Issue 1 (3-2020)
Abstract
Background & aim: The prevalence of obesity and the socio-economic consequences of it are effective in increasing mortality and cardiovascular disease. The aim of this study was to determine the effect of an aerobic exercise on the amount of epicedial adipose tissue, insulin resistance and some liver enzymes in the fattened vestibular rats with a high-fat diet.
Methods: In the present experimental study conducted in 2018 in Yasuj, 32 Vistar male rats with a mean weight of 200-180 g and 6 weeks of age were randomly divided into 4 equal groups, including: normal nutrition, fattening with a high-fat diet, and then normal nutrition. Obesity with high-fat diet and aerobic exercise and normal nutrition after obesity were divided with high-fat diet. Sampling was performed in the obese group with a high-fat diet after obesity and in other groups 48 hours after eight weeks of aerobic exercise (four sessions per week with 60% of maximum training capacity). Lee index, relative amounts of epicardial adipose tissue, insulin, insulin resistance, fasting blood sugar, pericardial lipoprotein, low-density lipoprotein, total cholesterol and triglycerides, total lymphocytic acid differentiation, and differential enzymaphenazine aminophenazine alphanazinase and liver aspartate aspartate aminotropin. The data collected were analyzed using statistical tests of one-way analysis of variance and Tukey's follow-up test.
Results: The results indicated that a high-fat diet significantly increased the Lee index, relative amounts of epicardial adipose tissue, fasting blood sugar, insulin resistance, blood lipid profile and liver enzymes aspartate aminotransferase reduction and allanine amino acids. The significance of flagella lipoprotein was normal compared to the feed group (P ≥ 0.001). Eight weeks of aerobic exercise also significantly improved the values of Lee index (18.34%), relative values of epicedial adipose tissue (76.9%), insulin (4.01%), insulin resistance (37.48%). Fasting blood sugar (32.38%), high-density lipoprotein (23.65%), low-density lipoprotein (41.37%), cholesterol (24.68%) and total triglycerides (49.55%) as well as liver enzymes Aspartate amino transferees (45.9%), alanine amino transferase (44.34%) and alkaline phosphatase (11.5%) were based on values (P≥ 0.001).
Conclusion: Aerobic exercise reduced the amount of epicedial adipose tissue, body fat mass index, insulin resistance, fatty liver index and cardiovascular risk factors for obesity. Therefore, aerobic exercise can be considered as one of the ways to change the hepatic metabolism and the health of the cardiovascular system in the treatment of related metabolic and cardiovascular diseases caused by immobility and obesity.
B Hasanvand, Y Mehrialvar, H Parsa, A Heydarian , F Erfani,
Volume 26, Issue 2 (4-2021)
Abstract
Background & aim: Adipose tissue is not just a source of excess energy storage, but an endocrine organ that regulates biological functions by endocrine role by releasing adipokines that act like real hormones. The aim of this study was to investigate the effect of exercise intensity and saffron supplementation on the response of adipokines to insulin resistance markers in obese and overweight women.
Methods: The present research method is quasi-experimental. Among obese and overweight women using G-Power software, 42 obese women with a body mass index above 25 were selected in a purposeful and accessible manner and randomly divided into six groups of intense intermittent exercise, continuous exercise, control, Intense intermittent exercise with saffron supplement, continuous exercise with saffron supplement and saffron supplement group were divided. After the initial sampling, the intervention groups worked for eight weeks. In order to eliminate the response of the last training session, blood sampling was performed 48 hours after the last training session. All data analysis was performed at a significance level of P≤0.05 with analysis of covariance.
Results: There was a significant difference in the variables of weight, body mass index and fat percentage between the control group and training interventions and saffron (P<0.005). In the irizin variable, the results showed that there was a significant difference between periodic exercise + saffron, endurance + saffron with the control group (P=0.001). But there was no significant difference between the periodic training group + saffron and the endurance + saffron group (P= 0.9). In the lipocalin variable, the results showed that there was a significant difference between training interventions and saffron (except endurance training intervention) with the control group. The results also showed that there was no significant difference between the periodic training group + saffron and the intense periodic training group (P=0.7). The results also showed that there was no significant difference between the endurance group (P=0.1) and saffron (P=0.9) in the LDL variable compared to the control group. In the HDL variable, the only group that was significantly different from the control group was the intense periodic exercise group + saffron (P=0.03). In the cholesterol variable, the only group that was significantly different from the control group was the intense periodic exercise group + saffron (P=0.003). There was a significant difference in the triglyceride variable of the severe periodic group + saffron (P=0.001) and also the severe periodic group (P=0.03) with the control group. There is a significant difference in insulin and insulin resistance between all groups (except saffron) and the control group (P=0.001). The results also showed that there was no significant difference between insulin changes and insulin resistance between any of the exercise interventions (P=0.9). There was no significant difference in glucose between any of the groups (P=0.9).
Conclusion: Saffron and higher intensity activity can have regulatory effects on the body's metabolic balance: The use of saffron and exercise improves the serum lipid profile and ultimately leads to improved insulin resistance.
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