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Background & aim: Diabetes is a chronic disease which induces a rise in inflammatory response and endothelial disorders. The aim of present study was to review the response of ICAM-1, VCAM- 1 and CRP serum level to high and moderate endurance trainings in diabetic rats.

Methods: In the present experimental research, thirty-two diabetic male sprague dawley rats were selected and based on their blood glucose, they were divided into four groups of eight: (1) diabetes sacrifice first week, (2) diabetes sacrifice last week, (3) moderate intensity endurance training and (4) high intensity endurance training and for review the effects of diabetes induction 16 healthy rats divided in two groups of healthy sacrifice first week and healthy sacrifice last week. Rats of high and moderate intensity endurance trainings ran on treadmill for eight weeks, three sessions per week and 60 minutes with intensity of 10- 17 and 17- 28 meter per minute. To analyze the data, the Kolmogorov-Smirnov tests, ANOVA with Tukey test was used.

Results: Results indicated that induction of diabetes resulted in a significant increase in ICAM-1 (p=0.001), VCAM- 1 (p=0.001) and CRP (p=0.001) respectivly. Eight weeks moderate and high intensity endurance training showed a significant reduction on ICAM-1 (p=0.001), VCAM- 1 (p=0.003) and CRP (p=0.001) and such reduction on ICAM-1 (p=0.04), VCAM- 1 (p=0.04) and CRP (p=0.001) respectively. Also moderate and high intensity endurance trainings had equal effects on ICAM-1 (p=0.53), VCAM- 1 (p=0.90) and CRP (p=0.99) on diabetic rats.

Conclusion: Moderate and high intensity endurance trainings had equal effects on reduction of ICAM-1, VCAM- 1and CRP on diabetic rats.

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Background and aim: The use of exercise along with herbal supplements is one method proposed for controlling obesity and its complications. The aim of this study was to investigate the effect of 8 weeks aerobic training and use of hydro-alcoholic extract of nettle on levels apelin and hs-CRP plasma in overweight and obese women.

Methods: The present quasi-experimental study was conducted with blind randomized clinical trial. 46 overweight and obese women (body mass index greater than 25 kilograms per square millimeter two, aged 25-45 years) were selected purposefully and randomly divided into four groups of: aerobic training + hydro alcoholic extract of nettle, aerobic exercise + placebo extract of nettle and placebo. The intervention group and placebo received 8 mg of hydro alcoholic extract of nettle 8 ml of water-soluble daily for 8 weeks respectively. Aerobic exercise ergometer for 8 weeks, 3 sessions of 16 to 30 minutes with the intensity of 60-75% heart rate was reserved. In two pre and post-test after 14 hours of fasting at the same conditions, blood samples were collected. The ELISA method was use to assess levels of plasma apelin and hs-CRP d. Data obtained were analyzed using the Kolmogorov-Smirnov test, ANOVA, t-test and LSD test.

Results: The results showed that the levels of hs-CRP were significantly different in comparison among the groups as well as in groups of aerobic exercise + hydro alcoholic extract of nettle, nettle and hydro-alcholic aerobic exercise + placebo significant reduction was observed (p>0.05).

Conclusion: It seems that consumption of Nettle extract along with aerobic exercise through

Weight loss, body fat percentage and BMI, play an effective role in control of obesity and reducing of inflammatory Apelin markers and hs-CRP in obese women

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Background and Aim: Diabetes is known as the most common metabolic endocrine disorder that causes debilitating complications of the eye, renal, neurological and cardiac diseases, and has irreparable biological, psychological, social and economic consequences. The aim of this study was to determine the effect of water exercise on glycosylated hemoglobin and C-reactive protein in type 2 diabetic women.

Methods: In this semi-experimental study, 30 type II diabetic women were selected and randomly assigned to either control (n = 15) or control (n = 15). The experimental group performed 8 sessions per week for 3 sessions and 60-70 minutes each exercise protocol in the cramped pool. During this study, no intervention was performed on the control group. Data were analyzed for the comparison of intra-group of correlated T-test and inter-group comparison of independent t-test              (p<0.05).

Results: The result showed that the exercise in water in the experimental group, body mass index (p <0.015), waist to hip ratio (p <0.022) and body fat percentage (p> 0.04) significantly decreased. Also, the results of independent t test showed that HOMA-IR (P=0.013), CRP (P=0.001), HbA1C (P=0.001), significantly decreased in experimental group compared with control group.

Conclusion: It can be suggested that eight weeks of exercise in water by decreasing anthropometric indices, CRP levels, glycosylated hemoglobin, and insulin resistance index can prevent type 2 diabetes and its metabolic complications.


 
 

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Background and objective: The development of cardiovascular diseases and mortality caused this study to evaluate the effect of 6 weeks of supplemental diet and aerobic exercise on plasma levels of CRP and fibrinogen in overweight men.
Method: 32 non-athletic overweight men from Qom University with a mean age of 31 ± 1.38 years, and body mass index 31.19 ± 4.18 kg / m2, were randomly assigned to four groups (8 subjects), supplemented (8 subjects ), Exercise + complement (7 subjects) and control (n = 10 subjects). The control group did not undergo any training and supplementation during 6 weeks, The exercise group performed 6 weeks aerobic training with an intensity of 60-74% of maximum heart rate and 3 sessions per week. The supplemented group consumed 6 weeks of garlic-Lemon and the exercise + supplement group consumed complementary supplements and aerobic exercise for 6 weeks. Blood sampling was performed to measure CRP and Fibrinogen and general tests including height, weight, fat percentage, waist to hip ratio in two stages before and 48 hours after the last training session in fasting conditions. The t-test was used to examine the differences between groups and one-way ANOVA was used to examine the differences between groups.
Results: A significant decrease in fat percentage was observed in the supplementation group (p = 0.035) Also, the results did show decrease significant changes in CRP and fibrinogen in the Exercise + complement and supplemented groups, thus CRP level in the Exercise + complement group was 27% and the supplementation group was 26% and the fibrinogen level in the Exercise + complement group was 38% and in the supplemented group 29% has decreased.
Discussion: According the decrease significant in inflammatory levels in this study, but a significant reduction in the percentage of these variables was observed in the study, it seems that the implementation of the garlic-Lemon supplementation protocol can be effective in changing these indices and reduce the risk of cardiovascular disease.

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Introduction: Carbohydrate and caffeine mouth rinses are commonly used to enhance athletic performance. This study aims to examine the combined effect of time of day and mouth rinsing with a carbohydrate and caffeine solution on time to exhaustion, levels of the inflammatory marker C-reactive protein (CRP), and muscle strength in female athletes.
Method: A total of 24 non-menopausal female athletes were recruited for the study and randomly assigned to either an experimental (N=12) and control (N=12) group. Participants underwent the Bruce treadmill test twice, once in the morning and once in the evening. In a single-blind design, the experimental group received 25 cc of 6% glucose + 1.2% caffeine solution, while the control group received 25 cc of distilled water solution in the interval of 30 minutes before the start of the test, every 15 minutes, they reeled in the mouth for 10 seconds and poured it out.The variables measured included time to exhaustion, CRP levels, and muscle strength, both in the morning and evening. Data were analyzed using repeated measures ANOVA.
Results: No significant differences were found between the experimental and control groups regarding time to exhaustion or chest press performance, regardless of the time of day (P ≥ 0.05). However, time of day had a significant effect on CRP levels (p = 0.006). Additionally, there was a significant interaction between time of day and group (p = 0.03), and the group effect on CRP levels was also significant (p = 0.05). Notably, CRP levels were significantly higher in the evening compared to the morning and baseline levels (p = 0.01).
Conclusion: The findings suggest that a carbohydrate and caffeine mouth rinse can significantly influence the inflammatory response, with a more pronounced effect observed in the evening. This strategy may be beneficial for improving the health and performance of female athletes.