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Showing 3 results for C-Reactive Protein

M Khorramjah , M Sarmadiyan , D Khurshidy ,
Volume 21, Issue 9 (12-2016)
Abstract

Background and aim: The risk of cardiovascular disease in women increases after menopause. The aim of this study was to investigate the effect of aerobic exercise at moderate intensity levels of cystatin C  and some cardiovascular risk factors in inactive postmenopausal women.

Methods: In this quasi-experimental study, 24 sedentary postmenopausal women (50-65 years) were  randomly divided into two experimental groups (n=14) and control group (n=10) groups. The experimental groups performed an aerobic training with 65 to 75% of maximum heart rate , 3 days per week for 10 weeks. Body fat percentage and serum levels of cystatine C with high sensitivity, C-reactive protein, HDL, LDL, triglyceride, cholesterol and blood pressure were measured at baseline and after training. Data were analyzed using analysis of covariance test.  

Results: No significant difference was seen  after performing aerobic training on serum levels of cystatin C (p=0.761), C-reactive protein with high sensitivity (p=0.378), triglyceride (p=0.48)   ), high-density lipoprotein (p=0.54), low-density lipoprotein cholesterol (p=0.86), cholesterol (p=0.67), percent body fat (p=0.57) between the two groups. There was no significant difference between control and experimental groups in the variable maximal oxygen uptake (p = 0.035) and systolic blood pressure (p =0.04).

Conclusion: It seems that short-term aerobic training have no effet on serum levels of cystatin c and some moderate-intensity cardiovascular risk factors like reactive protein C, total cholesterol, high density lipoproteins, lipoprotein help disabled density and blood pressure in  in inactive postmenopausal women.


Mr Ataee , Gh Alishiri , A Hesampoor Mahalati, Ra Ataee ,
Volume 24, Issue 4 (9-2019)
Abstract

Background & aim: Microbial super antigens have reported in blood and synovial fluid of rheumatoid arthritis patients. Whether or not, the presence of these super antigens could provoke the induction of serologic diagnostic factors, including CRP in patients? the purpose of this study was to production and purification one of the super antigen C of Staphylococcus aureus and itʹs effect on the induction of CRP in rat
 
Methods: In this experimental study which was performed from December 2017 to September 2018 at the Baqiyatallah University of Medical Sciences. Twenty Wistar rats weighing 250 to 300 Grams were selected and divided into four groups of 5 members, included. By participated to workshops of animal laboratory control as well as intraperitoneal and intera-articular injection were carried out. Staphylococcus aureus super antigen C was purified by ultrafiltration (Amicon Ultra Centrifugal Filter Device) form 24 hours culture media and use specific antibody for immunoblotting confirmatory was carried out. The protein concentration was measured. 50 micrograms of toxin were injected intraperitoneal and intra- articular into separate rat groups. In time course blood collection and CRP was tested. The results were analyzed.
 
Results: The results showed that 50 to 100 μg of toxin intra- articular and intraperitoneal after 20 days inducted CRP production at 0.7 mg. After 40 days, this increased to 2. 2 mg/lit and after 50 days it reached to 4.5 mg/lit. ANOVA analysis was shown the difference between the groups and with a significant level for groups was P≤ 0.001 and for the intervals of the effect of super antigen was P≤ 0.075, respectively.
 
Conclusion: The results indicate that the presence and survival of staphylococcal super antigen C in the body of wistar rats induced the production of CRP factor. Although this finding is an introduction to further research, it is likely to provide new ways to prevent and control inflammatory diseases, including rheumatoid arthritis.
 
Purification, Superantigen C, Staphylococcus Aureus, C-Reactive Protein, Rheumatoid Arthritis
M Ahmadi , M Asadi , Z Rahami ,
Volume 28, Issue 1 (3-2023)
Abstract

Background & aim: Covid-19 is an emergent virus which has infected millions of people and triggered a serious circumstance all over the world. Due to the high prevalence of Covid-19 and limited treatment capacity, quick identification of factors which indicate the severity of the disease can be very helpful. The purpose of the present study was to determine and investigate the relationship between C-reactive protein and lymphopenia with the severity of the disease in hospitalized patients with Covid-19 in Yasuj, Iran, in 2019.

Methods: The present descriptive study was of retrospective type and available sampling method was used in 2019 on 206 patients with covid-19 where blood oxygen level, CT scan and CRP and blood lymphocyte levels were the main factors investigated. The sampling method was census and using a predetermined checklist, the required information was extracted from the files of patients admitted to the hospital. In this study, the background information of the patients including age, gender, clinical symptoms, length of stay in the hospital, the patient's condition based on discharge with relative recovery or death were collected. Furthermore, paraclinical information including: percentage of blood oxygen saturation, white blood cell count, lymphocyte, CRP and lung involvement in CT scan were extracted from the patients' files. The collected data were analyzed using the Willicion test and one-way analysis of variance.

Results: The participants in the present study included 206 people whose average age was 51.39 years. 103 (50%) were men and 103 (50%) were women. The results of one-way analysis of variance indicated that there was a significant difference in the amount of lymphocytes in patients with severe, moderate and mild disease based on the oxygen level (p=0.03), but the CRP level in these patients was based on the blood oxygen level (p=0.32).  CT scan (p=0.07) did not show any significant difference. In addition, there was no significant difference in the amount of lymphocytes in patients with severe, moderate and mild corona based on CT scan (p=0.14).

Conclusion: According to the findings obtained from the present study, it appeared that the level of lymphopenia can be used to predict the severity of the disease in patients with covid-19, but the level of CRP can be used to predict the severity of the disease in Covid-19 patients cannot be used based on the obtained results.


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