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Showing 12 results for afshar

Aa Poormahmoodi, J Mohamadi, A Mirzaeii, M Momeninejad, Ra Afshar,
Volume 8, Issue 1 (4-2003)
Abstract


Gh Dashti, E Esfandiari , M Nematbagksh, Mh Sanei , S Afsharipoor , A Farzan, M Jaafari Barmak ,
Volume 8, Issue 4 (1-2004)
Abstract

Introduction & Objective: Coronary arteries diseases and atherosclerosis are the most prevalent mortality and morbidity in the world. This study was designed with goal of effect of frankincense extract on accumulation of fatty streaks in coronary arteries of high- cholesterol fed male rabbits. Materials & Methods: Twenty white male rabbits (wt = 1.780 kg) were weighed and blood samples were taken for analysis of serum cholesterol, TG, LDL, HDL, VLDL. After taking the sample rabbits were randomly divided into two groups. For 40 days group 1 (n=10) was given high cholesterol (1%) diet with frankincense extract (500 mg/kg) and group 2 (n=10) were fed with high cholesterol with distilled water. Then, both groups weighted and blood samples were taken. Finally, the animals were sacrificed and their coronary arteries were dissected. Pathological smear were prepared and stained with H&E. The plaque of atherosclerotic was evaluated by light microscope. Results: Results of this study indicate that rabbits which received frankincense extract showed significant difference in cholesterol, TG, LDL, HDL, VLDL in compare with other group (p < 0.05). Also, our results showed a significant difference in mean of pathological scoring of four branch of coronary arteries (p < 0.05). Conclusion: Significant differences in all of parameters such as weight, serum cholesterol, TG, HDL, LDL, VLDL might be related to effect of frankincense extract on lipid metabolism. Pathological results showed that frankincense extract could decrease accumulation of fatty streaks in all branches of coronary arteries. Thus frankincense extract can be for preventing of used cardiovascular diseases, atherosclerosis and for treatment of lipidemia
S Amanat, H Afshar ,
Volume 11, Issue 3 (10-2006)
Abstract

ABSTRACT: Introduction & Objective: Post-traumatic stress disorder (PTSD) is a chronic illness which is difficult to treat yet, it is a common disorder which is associated with significant morbidity and mortality. The hypothesis that exposure to traumatic events may sensitize or kindle limbic nuclei has led to efforts to treat PTSD with anticonvulsants based on the kindling hypothesis. This double–blind clinical trial assesses clinical response to lamotrigine as a potential treatment. Materials & Methods: Thirty patients with PTSD were randomly assigned in a double – blind design. They were treated for 3 months with lamotrigine (N=15, 150-500 mg/day) as odd-on or placebo (N=15). The patients were measured in the first visit and at the end of 3 months by clinician administration. PTSD scales (CAPS) paired t-test, and Friedman and Will Coxon were used for data analysis. Results: The mean score of frequency of PTSD criteria in Lamotrigine group in the first visit was 10.1±2.2 and in placebo group was 12.75 ±2.24. The mean score of these criteria in lamotrigin group after treatment period was 9±2.5 and for placebo group was 12.45±2.7. The analysis of these sores showed a significant difference in Lamotrigine group and a non significant difference in placebo group. The mean score of Intensity of PTSD criteria in Lamotrigine group in first visit was 9.4±1.2 and in placebo group was 9.1±1.9. The mean score of these criteria in Lamotrigine group after treatment group was 8.4±2 and for placebo group was 9.1±2. The analysis of these scores showed a significant difference in lamotrigine group and a non-significant difference in placebo group. In placebo group, the analysis of mean sores of all intensity and frequency of criteria before and after taking placebo showed a non-significant difference. In Lamotrigine group, the analysis of mean scores of intensity and frequency of criteria such as avoidance of thoughts or feelings, avoidances of activities, place, people, inability to recall important aspect of trauma and diminished interest in activities before and after taking lamotrigine showed a significant difference and in other criteria showed a non-significant difference. Comparison of mean of decline in CAPS scores before and after treatment in placebo and lamotrigine group showed a significant difference in the four symptoms in lamotrigine group. Conclusion: Results of the study suggest that lamotrigine is a safe, well tolerated and significant effective treatment for avoidance numbing of PTSD.
H Afshar , N Masaeli, V Shayegan Nejad , Gh Asadolahi,
Volume 12, Issue 4 (1-2008)
Abstract

ABSTRACT: Introduction & Objective: The positive and negative effects of perfectionism on human cognition, affection and behavior have been emphasized. Perfectionism has been conceptualized as a multidimensional construct, with both adaptive and maladaptive aspects, which is one of the common personality traits that cause lifelong stress in human and results in anxiety, depression and physical and mental distress.The aim of this study was to assess the positive and negative perfectionism in migrainus patients in comparison with control group. Materials & Methods: This is an analytical (Case-control) study which was performed on 91 migraine patients and 88 healthy individuals. The pqtients and controls completed a standard 40 item questionnaire for perfectionism – PANPS (20 for positive and 20 for negative perfectionism ). The patients in both groups were matched for gender and age. Mean of positive and negative perfectionism scores for two groups was statistically analysed using SPSS software. Results: Mean positive perfectionism score was 83.47±8.5 for migraine group and 65.47±7.54 for control group (p=0.0001). The difference between two groups was significant. Mean of negative perfectionism score was 74.12±10.6 for migraine group and 51.79±7.8 for control group(p=0.0001). Conclusion: The results show that migraine patients have higher mean of perfectionism scores than healthy individuals. Based on this study and other clinical experiences more attention to psychotherapy is necessary for better management of migraine and recognition of personality profile in migraine patient helps to reduce patient’s complaints.
J Tavakkol Afshari , N Moheghi, A Brook,
Volume 15, Issue 2 (7-2010)
Abstract

Introduction & Objective: Biological activities of Zingiber afficieale plants have been reported as possessing anticancer, antibacterial, anti ulcer, antifungal, and insecticidal properties. However, its antitumor effects haven't been studied in cancer cell lines. The aim of this study was to investigate the antitumor effect of zingiber afficieale on breast cancer cell lines. Materials & Methods: This experimental study was conducted in 2010 at Mashhad University of medical Sciences. Breast cancer cell line (MCF7) and normal connective tissue cell line (L929) were cultured in DMEM medium. Ethanolic extract of Zingiber afficinale was prepared and cell lines were treated with different concentration of extract (5000 to 78 µg). Cell viability was measured by MTT assay after 24, 48, and 72 hours. The collected data were statistically analyzed by SPSS software. Results: The effects of Zingiber afficinale on cell viability were observed after 48 hours on cell lines. Ginger doses in 2500 µg concentration inhibited 50% of cell growth (IC50) in cell lines after 48 hours. Conclusion: Our study revealed that fresh ginger extract has cytotoxic effects on tumor cells, but it doesn’t have any cytotoxic effect on normal cells. It seems that ginger could be considered as a promising chemotherapeutic agent in cancer treatment.
A Brook , F Homaie , J Tavakkol Afshari , R Ganjali, M Afzalaghaee,
Volume 15, Issue 4 (1-2011)
Abstract

Introduction & Objective: Breast cancer is the most frequent malignancy among women worldwide. Polymorphisms in Xenobiotic Metabolizing Enzymes (XEMs) and drugs such as P450 (CYP2D6) may increase susceptibility to breast cancer. Little is known about the association of CYP2D6*4 (1894 G to A) polymorphism and susceptibility to breast cancer. This study aimed to investigate the possible relationship of the CYP2D6 *4 gene polymorphism and breast cancer. Materials & Methods: One hundred women with confirmed breast cancer and 100 healthy women were the subject of this study. Subjects were assessed for the gene polymorphism of CYP2D6 *4 by a PCR-RFLP assay at Mashad University of Medical Sciences in 2009. The collected data were analyzed by the SPSS using chi-square test and Fisher exact test. Results: No correlation was found between CYP2D6*4 gene polymorphism and breast cancer (P=0.299). Conclusion: Our results demonstrated that CYP2D6 *4 mutant displays a non-significant increased risk for breast cancer.
A Afshar Fard, M Hassani, H Molaeighovarchinghalee , F Hoseinzadegan , H Zohouri , S Naserinia,
Volume 17, Issue 3 (8-2012)
Abstract

Background & aim: Schwannomas are benign and slowly growing nerve sheath tumors which are usually solitary and encapsulated. They may arise from any peripheral nerve containing Schwann cells including distal portions of cranial nerves. Here we are reporting a case of Schwannoma presenting as sciatica. Case: A 30 years old woman admitted as severe chronic right lower limb pain, her complain was sciatica with an irregular prominent 15*10 cm mass found on her right buttock. She had normal laboratory data and MRI demonstrated extra muscular mass in posterior of mid zone of right thigh that was iso-signal in T1W1 and hyper-signal in T2W2. The patient underwent operation and sciatic nerve explored via posterior tight and unique neural branch of mass dissociated of sciatic and mass resected. Pathology report confirmed Schwannoma in the patient. Conclusion: In patients with sciatic pain, schwannoma nerve is one of the differential diagnosis and it needs to be considered in assessing of patients.
F Jahangiri , J Karimi , Mr Aminafshari ,
Volume 22, Issue 1 (4-2017)
Abstract

 
 
Background & aim: Psychological flexibility is a major component of health-related behaviors and refers to ability to get in touch with the present moment and insist on behavior modification in line with personal values. The purpose of this study was to comparing psychological flexibility in patients with irritable bowel syndrome and normal control group.
 
Methods: In a case-control study 61 patients with irritable bowel syndrome which were referred to gastroenterologist in Boroujerd, were selected via convenience sampling and compared with normal control group in psychological flexibility. Acceptance and Action Questionnaire (AAQ), Cognitive Fusion Questionnaire (CFQ), Mindful Attention Awareness Scale (MAAS) and Meaningful Live Questionnaire (MLQ) were used as research tools. Independent t test was used for data analysis. 
 
Results: The results showed that the difference between the two groups in terms of acceptance (p <0.006), mind-consciousness (p <0.001) and life based on internal values (p <0.006) is significant, as the band syndrome irritable bowel compared to the normal group received lower scores. In cognitive fusion (P <0.014) difference between two group was significant, so that the patient group achieved the higher scores. Both this findings mean lower psychological flexibility in individuals with irritable bowel syndrome.  
 
Conclusions: According to this study, patients with irritable bowel syndrome had lower levels of psychological flexibility than normal group and it can effective in initiating or exacerbating their symptoms.
 
 
N Habibollah-Pourzereshki , S Afshar Ghahramani, A Peymani,
Volume 23, Issue 5 (11-2018)
Abstract

Background & aim: Klebsiella pneumonia, is the most significant member of the enterobacteiaceae, which is one of the most important pathogen involved in health care associate infections. The capsular polysaccharide is a prominent virulence factor in the pathogenesis of this organism and serotypes K1and K2 are the most virulent types in human infections. The main aims of this study were to assess the antimicrobial susceptibility and to determine the distribution of serotypes K1, K2 by detecting of wzc and orf10 genes in clinical isolates of K. pneumoniae.
 
Methods: In the present cross-sectional study, a total number of 149 clinical isolates of K. pneumoniae were collected from patients admitted to educational hospitals of Qazvin. Bacterial identification was performed by standard laboratory methods. Antimicrobial susceptibility was determined by standard Kirby–Bauer disk diffusion method according to the Clinical Laboratory Standards Institute (CLSI) guideline. PCR assay was further performed for the detection of wzc and orf10 genes related to serotypes K1 and K2, respectively. The data were analyzed by using descriptive statistics and chi-square.
 
Results: totally, 98 (65.8%) of isolates showed multidrug resistance (MDR) pattern among those ceftazidime (61.8%) and cefotaxime (60.4%) showed the highest rates of resistance whereas amikacin and ciprofloxacin revealed high susceptibility rates as 91.3% and 59.1%, respectively. Results of the PCR assay showed that 79 (53%) isolates related to K1serotype, 19 (12%) to K2 serotype and 51 (34%) of isolates were belonged to non K1/ K2 serotypes. no significant association was seen between serotypes K1, K2 and MDR pattern (P< 0.05).
 
Conclusion: the present study indicated considerable rate of serotypes K1, K2 with MDR pattern among clinical isolates of K. pneumoniae collected from Qazvin hospitals. Considering the major role of these serotypes with high rates of drug resistance in different clinical infections, using of appropriate infection control measures and treatment strategies are essential to prevent further dissemination of these virulent and resistant isolates in studied hospitals.
 
 
H Afshar, A Abdi, A Barari , Ma Azarbayjani ,
Volume 26, Issue 1 (3-2021)
Abstract

Background & aim: Protein synthesis and degradation are dynamically regulated processes that to control the accretion or loss of muscle mass. However, the mechanisms responsible exercise-induced heart hypertrophy remains elusive. The aim of the present study was to investigate the effect of aerobic training on expression of some indices of myocardial hypertrophy and atrophy in male rats.
 
Methods: In this experimental study conducted in 2018, 16 wistar male rats 10 weeks old with 299.74±19.32 g weight were randomly classified into control and training groups. Training group performed an aerobic running program (at 10-18 m/min, 10-40 min/day, and 5 days/week) on a motor-driven treadmill for six weeks. At the end of six week’s heart tissue samples were collected and used for determination of gene expression (AMP-activated protein kinase, fork head Box O3, Muscle atrophy F-box and Muscle RING finger 1). Data were analyzed using Independent t test at p<0.05.
 
Result: Six weeks aerobic training significant increased the heart AMP-activated protein kinase in rats (p=0.014). Also heart fork head Box O3 (p=0.022), Muscle atrophy F-box (p=0.032) and Muscle RING finger 1 (p=0.028) was significantly decrease than training group.
 
Conclusion: Aerobic exercise improved the heart structure by improving the parameters that affect cardiac size, possibly improving cardiac function.
 


E Hosseini , M Shahhosseini, P Afsharian, F Mehrayin , M Ashrafi, R Aflatoonian ,
Volume 28, Issue 5 (9-2023)
Abstract

Background & aim: Among the important factors affecting female infertility, endometriosis (with a prevalence rate of up to 50% in infertile women) has a special place. Endometriosis, which is known as the presence of endometrial glands and stroma outside the uterine tissue, causes a wide range of functional disorders in the process of follicular development and changes in the follicular microenvironment, which ultimately leads to the creation of an egg that is of suitable quality for the formation of The fetus does not have Therefore, the aim of the present study was to determine and investigate post-translational changes of histones, DNA methylation level and ERβ protein level in the genome of cumulus cells of infertile women with endometriosis.

Methods: The present case-control study was conducted at the infertility treatment clinic of Royan Research Institute in 2014. Twenty-four patients were divided into two equal groups. Cumulus cells were obtained from 12 infertile patients with endometriosis and 12 women with male factor infertility (as a control group) under ovulation stimulation protocols for intracytoplasmic sperm injection. Extraction of chromatin from cumulus cells was done after stabilization of DNA binding proteins and then cell lysis and preparation of soluble chromatin. The binding and incorporation levels of MeCP2 protein (as DNA methylation marker), two epigenetic markers related to histone modifications (H3K9me2 and H3K9ac), and ERβ protein to chromatin of cumulus cells were evaluated using the corresponding primary antibodies, secondary antibodies conjugated and Nucleosome-ELISA technique. Data were analyzed using independent t-test t and Levene's test.

Results: MeCP2 protein incorporation into DNA was significantly higher in the endometriosis group than in the control group. The level of two epigenetic marks H3K9ac and H3K9me2 in the chromatin of cumulus cells of the patient group showed a significant increase compared to the control group (P<0.05). In addition, an increased level of binding of ERβ protein to the genome was observed compared to the control group.

Conclusion: Epigenetic changes, including histone hyperacetylation and hypermethylation, and DNA hypermethylation of the whole genome of cumulus cells of patients with endometriosis had occurred, accompanied by an increase in the level of ERβ protein binding.

.

S Afshar Yousefi , Y Kazemzadeh, H Shirvani , S Mirzayan Shanjani ,
Volume 29, Issue 5 (10-2024)
Abstract

Background & aim:  Lifestyle modification and the use of nanotechnology are considered therapeutic strategies for cancers. Therefore, the aim of the present study was to determine the effect of combined exercise and curcumin supplementation on the expression of T cell factor 1 (TCF-1) and glycogen synthase kinase 3 beta (GSK3β) genes in the brains of mice with glioblastoma multiforme.

Methods: In the present experimental study conducted in 2023 at the Islamic Azad University, 40 male Wistar rats were divided into 5 healthy control groups, glioblastoma multiforme (GBM), GBM+ combined training (CT), GBM+ nanocurcumin supplement (N-CUR) and GBM+CT+N-CUR (8 rats in each group). Glioblastoma was injected into the frontal cortex of rat. Exercise training was performed for 4 weeks and 3 days per week as a combination of aerobic and resistance training. Nano curcumin supplement was gavage with a dose of 80 mg/kg for 4 weeks, 5 days per week. At the end, rats sacrificed and TCF-1 and GSK3β genes of brain glioblastoma were analyzed by Real-time PCR method. The collected data were analyzed using Shapiro-Wilk, Levin, one-way analysis of variance, Tukey's post hoc test and Pearson correlation.

Results: The results of the present study indicated that the expression of TCF1 mRNA and GSK3β mRNA in the brain tumor tissue of rats showed a significant increase compared to the healthy control group (p<0.0001 for both). However, compared to the GBM group, all the treatment groups, especially the GBM+CT+N-CUR group, indicated a significant decrease in the expression of TCF1 mRNA and GSK3β mRNA in the brain tumor tissue (p<0.05). The correlation between these two factors was not confirmed in different research groups (p>0.05). Based on histological image, tumor induction caused tissue integrity destruction and the level of inflammatory factors and lymphocytes infiltration in this tissue also expanded. However, exercise training and nano curcumin supplementation led to control of tumor tissue damage and reduction of tumor tissue, and these changes were greater in combination therapy.

Conclusion: It seemed that the combination of exercise and Nano curcumin supplement could be an effective treatment method in down regulation of some effective genes in brain tumor tissue. Therefore, they can be used during the recovery period or cancer treatment with the doctor's order. However, in this field, more studies are needed, especially in human samples.

 

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