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Showing 2 results for Ilkhanipoor
M Mohammadzadeh , S Sharifzadeh, M Ilkhanipoor , V Nejati , R Heidari ,
Volume 23, Issue 1 (4-2018)
Abstract
Background & Aim: Nowadays, the use of herbal products as supplementary or substitute chemical drugs in the treatment of diseases has been associated with low side effects and cost of treatment. The aim of this study was to evaluate the effect of cinnamon aqueous extract on anxiety-like behavior of streptozotocin-induced diabetic male rats.
Methods: In this experimental study, 28 male Wistar rats weighing approximately 200±30 g were used in four groups of seven. For induction of diabetes mice, intraperitoneal injection of 50 mg / kg streptozotocin was used. The experiments were designed for 3 weeks. During this period, the treatment was performed by cinnamon extract at a concentration of 200 mg / kg orally. At the end, recording and evaluation of the anxiety behavior evaluation indicators of mice including duration of presence and The number of access times in the open arms is performed at a set time interval for a period of 5 minutes with a plus maze device. Data were analyzed by one-way ANOVA and Tukey's post hoc test.
Results: There was no significant difference in the duration of presence in the open arms of the elevated plus maze (EPM) between healthy rats receiving cinnamon extract. Also, the results showed that the duration of presence in the open arms of the maze in the control rats Diabetic and diabetic recipients of cinnamon extract were significantly less than healthy ones. The results showed that the duration of presence in the open arms of maze in diabetic control and diabetic rats receiving cinnamon extract was significantly lower from healthy groups (controls and recipients of cinnamon extract). In general, increased anxiety behaviors in diabetic rats Indicates anxiety levels in diabetic rats treated with a small extract compared to diabetic control group, but this is not statistically significant (P≤0.05).
Conclusion: Cinnamon extract has no effect on anxiety and anxiety-like behaviors due to decreased blood glucose. Therefore, it can be suggested that on the one hand, the concentration of cinnamon used to treat diabetic rats is not sufficient to reduce blood glucose and has no effect on the performance of anesthetic neurotransmitter systems.
H Ilkhanipoor , Sm Razavinejad , M Asadi , R Oboodi , F Yarmahmoodi , H Barzegar,
Volume 28, Issue 6 (12-2023)
Abstract
Background & aim: In the present day, with the improvement of clinical care, the number of cases of premature and low birth weight babies who survive has increased. This group of babies usually achieve compensatory and faster growth than the average growth for their age and gender in the first two years of life. Also, small for gestational age (SGA) babies often have low birth weight (less than 2500 grams). These babies usually achieve compensatory growth at 2-3 years old. But if they cannot achieve this rapid compensatory growth, they may need therapeutic interventions including growth hormone administration. Therefore, the purpose of the present study was to determine and investigate growth indicators as an important health assessment criterion in 2-4-year-old children with a history of prematurity and low birth weight.
Methods: The present retrospective cross-sectional descriptive study was conducted in 2018-2019 on 96 children between 2 to 4 years of age who were born prematurely or with a low weight (less than 2500 grams). The hospitalization records of these children hospitalized at Hafez and Namazi hospitals of Shiraz were examined. Parents were invited to participate in the study through an online application. Growth indices including head circumference, height and weight were measured by a trained physician. Body mass index and Z-score were calculated for these indices and growth indices at birth were collected from their hospital records. The collected data were analyzed using t-test, chi-score and analysis of variance.
Results: 96 children were included in the study, 12.5% of children were small for their gestational age at the time of birth, and at the time of evaluation in the present study. All participants had reached the appropriate height and head circumference for their age, but 5 (41.6%) children were underweight. 45 (46.9%) children had growth disorder at the time of examination, 31 (32.3%) children were referred for laboratory evaluation and 3 (3.1%) children were treated with growth hormone. In this study, 33 (34.4%) children were underweight and 4 (4.2%) were short, 38 (39.6%) had a low body mass index (less than 2SD).
Conclusion: Premature and LBW infants need more attention for growth in follow-ups. Physicians should be aware of growth delay or arrest to do the best intervention at the time. They may need to refer to a pediatric endocrinology clinic at the proper time.
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