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:: Volume 19, Issue 11 (2-2015) ::
__Armaghane Danesh__ 2015, 19(11): 930-937 Back to browse issues page
The Effect of Pomegranate Seed Oil on the Proliferation of Human Breast Cancer Cell Lines MCF-7 and MDA-MB468
Mahsa Servatkhah 1, Reza Mahmoudi 1, Alimohamad Kamali 1, Maryam Tajale 1, Mehrzad Jafari barmak 1, Mohsen Nikseresht 2
1- Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
2- Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran , nikmohsen@yahoo.com
Abstract:   (1928 Views)
Background and aim: Breast cancer is the most common cancer which is threatening the health of women worldwide. Recent studies have found that pomegranate seed oil extract, may have potential anti cancer effect(s). The purpose of this study was to investigate the effects of pomegranate seed oil on the proliferation of human breast cancer cell lines MCF-7 and MDA-MB468. Methods: MCF-7 and MDA-MB468 cell lines were provided and grown in the culture media of RPMI-1640 containing 10% fetal bovine serum with the proper antibiotic. The pomegranate seed oil was extracted using petroleum ether. Cells were treated with different concentrations of pomegranate seed oil (100-1500 µg/ml) and viability was evaluated by using MTT assay. All of the experiments were performed triplicate. Result: After a period of 24, 48, and 72 hrs, the IC50 in MCF-7 cell lines and MDA-MB468 cell lines were 1150,742,731µg/ml and 842,700,588 µg/ml, respectively. Conclusions: The results revealed that pomegranate seed oil has the cytotoxicity effect on the two mentioned cell lines. Moreover, at different times with different concentrations, it (time and concentration dependent) prevented the proliferation of breast cancer cells. Therefore, perhaps it takes as a nutritional factor in the prevention of breast cancer.
Keywords: MCF-7 cell line, MDA-MB468 cell line, pomegranate seed oil, MTT assay
Full-Text [PDF 160 kb]   (707 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/03/1 | Accepted: 2015/03/1 | Published: 2015/03/1
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Servatkhah M, mahmoudi R, kamali A, tajale M, jafari barmak M, nikseresht M. The Effect of Pomegranate Seed Oil on the Proliferation of Human Breast Cancer Cell Lines MCF-7 and MDA-MB468 . Armaghane danesh. 2015; 19 (11) :930-937
URL: http://armaghanj.yums.ac.ir/article-1-83-en.html


Volume 19, Issue 11 (2-2015) Back to browse issues page
ارمغان دانش Armaghane danesh
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