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:: Volume 20, Issue 7 (10-2015) ::
__Armaghane Danesh__ 2015, 20(7): 611-622 Back to browse issues page
Protective Effect of Royal Jelly following Phenylhydrazine-induced Hepatotoxicity in Mice
Hojjat Anbara1, Ali Shalizar Jalali 2, Rasuol Shahrooz1, Mazdak Razi1
1- Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran , ali_shalizar@yahoo.com
Abstract:   (3912 Views)

Background & aim: Phenylhydrazine (PHZ), a recognized oxidant agent, can cause a variety of side effects including hepatic disorders. The present study aimed to explore the possible hepatoprotective effects of royal jelly (RJ) with antioxidant and anti-inflammatory activities on PHZ-induced hepatotoxicity in mice. Methods: In this randomized controlled experimental study, adult male mice were categorized into four groups of eight mice each. Two groups of mice received PHZ at a dose of 60 mg/kg per 48 hours intraperitoneally for 35 days. RJ was administered to one of these groups at a dose of 100 mg/kg per day orally four hours before PHZ injection. A vehicle-treated control group and a RJ-only treated group were also included. Serum and hepatic samples were collected 24 hours after the last treatment and subjected to biochemical and histomorphometric examinations, respectively. The data were analyzed by one-way analysis of variance followed by Duncan test for post hoc comparisons. Results: PHZ treatment caused a significant elevation (P < 0.05) in serum concentrations of aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and malondealdehyde and decreased serum level of total antioxidant capacity, superoxide dismutase and albumin. Moreover, PHZ significantly increased diameters of hepatocytes and their nuclei as well as number of Kupffer cells. Notably, RJ pretreatment improved all changes in the above-mentioned parameters. Conclusion: RJ by virtue of its antioxidant properties can reduce PHZ-induced hepatic damages in mice. However, the exact mechanism by which RJ cause these effects merits further studies.

Keywords: Royal jelly, Phenylhydrazine, Liver, Mouse
Full-Text [PDF 235 kb]   (1217 Downloads)    
Type of Study: Research | Subject: Anatomy
Received: 2015/02/18 | Accepted: 2015/08/10 | Published: 2015/09/2
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Anbara H, Shalizar Jalali A, Shahrooz R, Razi M. Protective Effect of Royal Jelly following Phenylhydrazine-induced Hepatotoxicity in Mice . Armaghane danesh. 2015; 20 (7) :611-622
URL: http://armaghanj.yums.ac.ir/article-1-68-en.html


Volume 20, Issue 7 (10-2015) Back to browse issues page
ارمغان دانش Armaghane danesh
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