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Antiatherogenic and Antioxidant Effects of Valine on Coronary Arteries of Hypercholesterolemic Animals
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A Movahedian   1, GR Dashti , GA Naderi , M Khademiezadeh |
| 1- , movahedian@pharm.mui.ac.ir |
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Abstract: (5132 Views) |
| Introduction & Objective: The decrease of peroxidantion of
lipoproteins as a key event in the development of atherosclerosis
by increasing plasma antioxidant capacity might be an effective
approach in preventing such diseases. It has been shown that
some amino acids and polyamines have antioxidant activity. In this
study antioxidant and antiatherogenic effects of valine in
hypercholesterolemic rabbits have been investigated.
Materials & Methods: fifteen male white rabbits were divided into
three groups including: normal control, hypercholesterolemic
control and hypercholesterolemic treated with L-valine. Animals
were fed with special diets for five weeks and then plasma total
cholesterol (TC), triglyceride (TG), high density lipoprotein
cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C),
conjugated diens (CDs), malondialdehyde (MDA) and antioxidant
capacity (AC) were measured. Coronary arteries were obtained in
order to measure fatty streaks formation by histological studies.
Results: No significant difference was observed in plasma TC,
LDL-C and CDs levels between valine treated and
hypercholesterolemic control groups. However the levels of TG,
HDL-C and MDA in valine-treated group showed a significant
differences in comparison with hypercholesterolemic control group
(p<0.05). Comparison of serum antioxidant capacity in valine
treated group showed significant increase comparing to
hypercholesterolemic control group. The mean size of produced
fatty streaks also showed significant reduction in valine-treated
group in comparison with hypercholesterolemic control group
(p<0.05).
Conclusion: The results showed that valine can prevent the
formation of fatty streaks in hypercholesterolemic rabbits by
increasing of serum antioxidant capacity and decreasing the level
of lipid peroxidation. |
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| Keywords: Fatty, Atherosclerosis |
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Full-Text [PDF 362 kb]
(1107 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/06/1 | Accepted: 2015/06/1 | Published: 2015/06/1
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