Introduction: In the recent decades, many researches have been conducted to prevent destructive effects of gamma-ray on the body tissues. One of these researches is the use of radio-protector before radiation. In this study, we examine para-amino propinophenone (PAPP) effects, as a radio-protector, on the variations of Gonadotropin and testosterone.

Materials and Method:In this experimental study, 70 adult male rats were studied. They were randomly divided into 10 septet groups. Control group received food and water; and no more experimental material was given or fed. Sham group receivedsolvent(ethanol 96%). Groups3,4 and 5 received10, 20, 40 mg/ kg of PAPP were injected. Group 6 was influenced by gamma-ray (2greys). Group 7 were given 1ml ofethanol and after a half an hour were influenced bygamma-ray (2greys).Groups8, 9 and 10 received 10, 20, 40 mg / kg of PAPP respectivelyafter a half an hour were influenced by gamma-ray (2greys).All injections continued for 3 days.All groups were bled to measure their testosterone, FHS and LH hormones.Statistical analysis carried out by SPSS 19 software.

Results: The findings show that in the groups treated by gamma-ray, the amount of testosterone, FHS and LH hormones were reduced significantly compared with control group (P≤ 0.05). In the groups treated by para-amino Propiophenone (PAPP) and gamma-ray (from low to high concentrations), the level of testosterone, FHS and LH hormones increased gradually so that in maximum level, the hormone level reached to control level.

Conclusion: PAPP reduced the damages caused by gamma-ray on the amount of testosterone, FHS and LH hormones. Its protective effect is dosage-dependent. It seems that PAPP protects cells and tissues from destructive effects of free radicals caused by gamma-rays, through hypoxia.