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:: Volume 18, Issue 4 (8-2013) ::
__Armaghane Danesh__ 2013, 18(4): 272-283 Back to browse issues page
Effect of Fenugreek Seed Extract (Trigonella Foenum-graecum) on Brachial Region of the Spinal Cord of an 18-Day Old Rat Offspring with Diabetes
Z Khaksar, E Tavakol Kookhdan 1
1- , tavakol@shirazu.ac.ir
Abstract:   (2937 Views)
Abstract Background & aim: Diabetes can affect the spinal cord, an important part of the central nervous system. Fenugreek seed has been suggested to have potential antidiabetic effects. This study was conducted to assess the effects of Fenugreek seed extract (trigonella foenum-graecum ) on fetal spinal cord structure, specifically in the brachial enlargement cord in an 18-day old fetus of diabetic mothers treated with extracts in comparison with the control groups' mothers. Methods: In the present cross-sectional study, sixteen healthy female rats were randomly divided into four equal groups: Healthy control, Diabetes control, Fenugreek control, Fenugreek treatment. Diabetes was induced by intraperitoneal injection of Streptozotcin (50 mg/kg). All four groups became pregnant by natural mating. After formation of the nervous system, two fetuses from each group were expelled by cesarean after performing anesthesia on the animals on 18th day of pregnancy furthermore their brachial enlargement spinal cord samples were taken. Finally, the tissue sections were prepared by routine procedures and diverse histological parameters were examined. The collected data were analyzed by one-way ANOVA. Results: results showed that fetal body weight on the diabetic control group was significantly higher compared to the other groups (P≤ 0/05). Moreover, significant reductions in the transvers and vertical diameters in central channel of the spinal cord and as well in the number of neurons of the spinal cord gray matter in the diabetic control groups in comparison with the other groups were observed (P≤0/05). Conclusion: The hyperglycemic effect of maternal diabetes during fetal period causes abnormalities, especially in the brachial enlargement of spinal cord, including changes in the spinal cord and neurons number in the gray matter. Disorders occurring in the prenatal remains and may perhaps cause lack of ability to perform certain physical activities. Key words: Fenugreek, Streptozotocin, Diabetes, Spinal Cord
Keywords: Key words: Fenugreek, Streptozotocin, Diabetes, Spinal Cord
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Type of Study: Research | Subject: Special
Received: 2015/04/27 | Accepted: 2015/04/27 | Published: 2015/04/27
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Khaksar Z, Tavakol Kookhdan E. Effect of Fenugreek Seed Extract (Trigonella Foenum-graecum) on Brachial Region of the Spinal Cord of an 18-Day Old Rat Offspring with Diabetes. Armaghane danesh. 2013; 18 (4) :272-283
URL: http://armaghanj.yums.ac.ir/article-1-340-en.html

Volume 18, Issue 4 (8-2013) Back to browse issues page
ارمغان دانش Armaghane danesh
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