[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Issue 6 (2-2012) ::
__Armaghane Danesh__ 2012, 16(6): 527-536 Back to browse issues page
The Effect of Subchronic Administration of the Aqueous and Hydro-alcoholic Extracts of Crocus sativus from Estahbanat, Fars Province, on Mice
M Emamghoreishi1, F Ghasemi
1- , emamm@sums.ac.ir
Abstract:   (4037 Views)
Background & aim: In Iranian traditional medicine, Crocus sativus L. has been defined as an exultant plant. The present study was undertaken to determine the effect of subchronic administration of aqueous and hydro-alcoholic extracts of Crocus sativus on mice. Methods: The effect of subchronic i.p. administration of different doses of the aqueous extract (50, 100, 200, 400 mg/kg or water) and the hydro-alcoholic extract (100, 200, 400, 800 mg/kg or water) of Crocus sativus stigma on immobility, climbing, and swimming behaviors were evaluated in the forced swimming test in mice. Fluoxetine (20 mg/kg) and imipramine (15 mg/kg) were used as reference drugs. Additionally, the effect of both plant preparations on spontaneous activity was examined. The collected data was analyzed using One-way ANOVA. Results: The aqueous extract at doses of 50 and 100 mg/kg produced a significant reduction in immobility along with an increase in climbing behavior which is similar to those which have been observed with imipramine. The hydro-alcoholic extract did not show significant effects on immobility, climbing and swimming behaviors of all studied doses, compared to control group. The aqueous extract of all studied doses and the hydro-alcoholic extract at dose of 1600 mg/kg decreased spontaneous activity. Conclusion: The results of this study suggests that the aqueous, but not hydro-alcoholic, extract of Crocus sativus stigma from Estahbanat in Fars province, in subchronic administration possess an antidepressant-like activity which may be mediated through norepinephrine system.
Keywords: Antidepressant, Saffron, Subchronic, Swimming test
Full-Text [PDF 573 kb]   (1145 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/04/25 | Accepted: 2015/04/25 | Published: 2015/04/25
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Emamghoreishi M, Ghasemi F. The Effect of Subchronic Administration of the Aqueous and Hydro-alcoholic Extracts of Crocus sativus from Estahbanat, Fars Province, on Mice. armaghanj 2012; 16 (6) :527-536
URL: http://armaghanj.yums.ac.ir/article-1-288-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 6 (2-2012) Back to browse issues page
ارمغان دانش Armaghane Danesh
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4540