Background & aim: Diabetes is a chronic disease which induces a rise in inflammatory response and endothelial disorders. The aim of present study was to review the response of ICAM-1, VCAM- 1 and CRP serum level to high and moderate endurance trainings in diabetic rats.

Methods: In the present experimental research, thirty-two diabetic male sprague dawley rats were selected and based on their blood glucose, they were divided into four groups of eight: (1) diabetes sacrifice first week, (2) diabetes sacrifice last week, (3) moderate intensity endurance training and (4) high intensity endurance training and for review the effects of diabetes induction 16 healthy rats divided in two groups of healthy sacrifice first week and healthy sacrifice last week. Rats of high and moderate intensity endurance trainings ran on treadmill for eight weeks, three sessions per week and 60 minutes with intensity of 10- 17 and 17- 28 meter per minute. To analyze the data, the Kolmogorov-Smirnov tests, ANOVA with Tukey test was used.

Results: Results indicated that induction of diabetes resulted in a significant increase in ICAM-1 (p=0.001), VCAM- 1 (p=0.001) and CRP (p=0.001) respectivly. Eight weeks moderate and high intensity endurance training showed a significant reduction on ICAM-1 (p=0.001), VCAM- 1 (p=0.003) and CRP (p=0.001) and such reduction on ICAM-1 (p=0.04), VCAM- 1 (p=0.04) and CRP (p=0.001) respectively. Also moderate and high intensity endurance trainings had equal effects on ICAM-1 (p=0.53), VCAM- 1 (p=0.90) and CRP (p=0.99) on diabetic rats.

Conclusion: Moderate and high intensity endurance trainings had equal effects on reduction of ICAM-1, VCAM- 1and CRP on diabetic rats.