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:: Volume 13, Issue 1 (4-2008) ::
__Armaghane Danesh__ 2008, 13(1): 89-95 Back to browse issues page
Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60
F Seif 1, MR Baiatiani Kheirolah, MJ Baiatiani Kheirolah, M Ansari, A Sohrabi, F Hosseini
1- , sahar_s59@yahoo.com
Abstract:   (1922 Views)
ABSTRACT: Introduction & Objective: The main purpose of radiotherapy is exposing enough doses of radiation to tumor tissue and protecting the normal tissues around it. Tumor dose for each session in radiotherapy will be considered based on radiosensitivity of the tissues. The presence of viral diseases in tumoral area can affect the radiosensitivity of cells. This study aimed to evaluate the radiosensitivity of Hela cells infected with poliomyelitis virus irradiated by Co 60. Materials & Methods: In this study, the radiosensitivity of HeLa cells, with or without the viral infection, after gamma radiation of cobalt 60, was assessed. Results: Results of comparison of the radisensitivity of infected and uninfected cells indicates that after 2 Gy irradiation by Co 60, polio infection in low, moderate and high virus load, increases the cell death by 20-30%, 30-40% and 70-90% respectively. Conclusion : Radiosensitivity of tumoral cells increase when they are infected with viral agents. Results of this study showed that non cancer diseases should be considered when prescribing dose fraction in radiotherapy of cancers.
Keywords: KEYWORDS:Radiosensitivity, HeLa Cells, Polio Virus
Full-Text [PDF 115 kb]   (546 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/05/31 | Accepted: 2015/05/31 | Published: 2015/05/31
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Seif F, Baiatiani Kheirolah M, Baiatiani Kheirolah M, Ansari M, Sohrabi A, Hosseini F. Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60. Armaghane danesh. 2008; 13 (1) :89-95
URL: http://armaghanj.yums.ac.ir/article-1-637-en.html


Volume 13, Issue 1 (4-2008) Back to browse issues page
ارمغان دانش Armaghane danesh
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