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:: Volume 11, Issue 2 (7-2006) ::
__Armaghane Danesh__ 2006, 11(2): 39-49 Back to browse issues page
Comparison of New Formulation of Diclofenac Diethylamonium Emulgel with Standard Preparation
SA Mostafavi 1, MA Shatalebi, M Yazdanian
1- , mostafavi@pharm.mui.ac.ir
Abstract:   (1862 Views)
Introduction & Objective: Oral route is a common route of administration for anti-inflammatory drugs including diclofenac. Due to some disadvantages of this route, the alternative routes of administrations are considered. The skin has been increasingly important in this regard, and many drugs have been formulated intradermal delivery systems. The purpose of this study was to prepare a topical diclofenac formulation emulgel with appropriate skin penetration and compare it with standard formulation. Materials & Methods: To prepare the formulation, we used the emulsion form. Several formulations containing different kinds and amounts of diclofenac salts, different emulsifying agents, and different HPMC concentrations were prepared. The skin penetration was evaluated by using Franz cell apparatus and the concentrations of diclofenac were determined in the receptor phase of Franz cell using spectrophotometer. The in vivo absorption of diclofenac was evaluated by determination of drug in urine. The concentration of drug was determined by HPLC. Results: In selected formulation, 85% of drug was released after 4 hours from formulation which was similar to drug released from standard formulation. The values of coefficient variation for HPLC method were utmost 15%. The range of variation in measurement was between 10 and 1000 ng/ml. Conclusion: The selected formulation had appropriate physicochemical properties. We were unable to measure drug concentrations in urine by the constructed HPLC, therefore it can be suggested that one should determine drug concentration in synovial fluid as the drug is concentrated in it.
Keywords: Sodium Diclofenac, Emulgel, Skin absorption
Full-Text [PDF 155 kb]   (594 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/06/6 | Accepted: 2015/06/6 | Published: 2015/06/6
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Mostafavi S, Shatalebi M, Yazdanian M. Comparison of New Formulation of Diclofenac Diethylamonium Emulgel with Standard Preparation. Armaghane danesh. 2006; 11 (2) :39-49
URL: http://armaghanj.yums.ac.ir/article-1-728-en.html


Volume 11, Issue 2 (7-2006) Back to browse issues page
ارمغان دانش Armaghane danesh
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