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:: Volume 20, Issue 8 (11-2015) ::
__Armaghane Danesh__ 2015, 20(8): 677-688 Back to browse issues page
Study of protective effect of Avicennia marina hydroethanolic leaf extract on testes tissue and spermatogenesis in male rat induced with carbon tetrachloride
Z Soleimani1, N Mirazi 2
1- Biology Department, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, Iran
2- Biology Department, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, Iran , mirazi205@gmail.com
Abstract:   (2327 Views)

Aim: The toxic chemical compounds are widelyused in the world. Carbon tetrachloride which is used in hygiene industries caused tissue disorders. Medicinal plants have protective effects in body tissues. In this study the protective effect of Avicennia marina leaf extract (MLE) on spermatogenesis in male rat were induced with ccl4 investigating. Method and materials: The 42 male rats with 220-250 gr body weight were divided randomly in 6 groups(n=7): control (taking normal saline,0.5ml/day, i,p ), sham(taking olive oil, 0.5ml/day, i,p single dose),group induced by ccl4(carbon tetrachloride 1:1 with olive oil,0.5ml single dose, i,p), treated groups: (1,2 and3 by carbon tetrachloride 1:1 with olive oil,0.5ml single dose and 200mg/Kg, 400mg/Kg and 800mg/kg MLE /day for 96 hrs, i,p). After the examination the blood samples were collected from heart directly and testosterone , FSH, LH , sperm count, sperm motility and GSI were analyzed and the microscopic studies of testes tissue were done. All data were expressed as mean±SEM. and statistical significance differences were accepted at P<0.05. Results: Our results showed that the carbon tetrachloride has necrotic effect in testes. The number of sperm and motility were increased and microscopic study of testes tissue showed the necrosis and inflammation with decrease in spermatogonia and spermatocytes comparedwith ccl4 induced only group significantly (P<0.001) and treated groups were no changed. Conclusion: the Avicennia marina hydroethanolic extract has antioxidant and flavonoids compounds which can protect the testes tissues from toxic chemical agents.

Keywords: Avicennia marina, spermatogenesis, testosterone, ccl4, rat
Full-Text [PDF 803 kb]   (753 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/07/6 | Accepted: 2015/09/15 | Published: 2015/10/12
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soleimani Z, mirazi N. Study of protective effect of Avicennia marina hydroethanolic leaf extract on testes tissue and spermatogenesis in male rat induced with carbon tetrachloride. Armaghane danesh. 2015; 20 (8) :677-688
URL: http://armaghanj.yums.ac.ir/article-1-951-en.html


Volume 20, Issue 8 (11-2015) Back to browse issues page
ارمغان دانش Armaghane danesh
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