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:: Volume 24, Issue 5 (11-2019) ::
__Armaghane Danesh__ 2019, 24(5): 853-864 Back to browse issues page
Prevalence of Bacterial Causes of Meningitis and Related Factors in Patients Admitted to Imam Sajjad Hospital in Yasuj
A Ghadimi Moghaddam 1, MA Ghatee2, A Keshtkari3, M Shabankare3
1- Department of Pediatrics, Yasuj University of Medical Sciences, Yasuj, Iran , dr_karim56@yahoo.com
2- Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
3- Department of Pediatrics, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract:   (2598 Views)
Background & aim: Bacterial meningitis is still recognized as one of the most dangerous infectious diseases that can lead to high mortality if not diagnosed and treated in a timely manner. The aim of this study was to determine the prevalence of bacterial agents causing meningitis and related factors in patients admitted to Imam Sajjad Hospital in Yasuj.
 
Methods:The present study was a cross-sectional descriptive-analytical study. The statistical population consisted of 106 patients one month to 14 years old referred to Imam Sajjad Hospital in 2018 who were analyzed for cerebrospinal fluid after clinical suspicion of meningitis. Spinal fluid sample of patients with white blood cell count greater than 5 was diagnosed as bacterial meningitis and one cc of it was stored at -20 ° C. Samples were analyzed for Meningococcus, Hemophilus influenza, Streptococcus pneumoniae and genotypes of this species using MULTIPLEX REAL TIME-PCR method by Tag Man method. Demographic, clinical and laboratory data were also collected and recorded. Data were analyzed using descriptive statistics and chi-square test.
 
Results: Of the total patients understudy, 33%(35) were female and 67%(71) were male. Most patients(50.9%) were between one month and one year of age. 34% (36 cases) of the specimens were confirmed as bacterial meningitis, 25 of which were pneumococcal and 11 of them were hemophilus influenzae type b. F19 genotype had the highest prevalence among pneumococcal genotypes. No positive results were found for meningococcus. Only one case of cerebrospinal fluid culture was positive, which was negative for coagulase staph. Also, only 8 cases(89.6%) had positive blood cultures. The most common clinical symptom was fever. There was a statistically significant difference between the negative PCR group and the positive PCR groups for vomiting (p=0.01), rash(p=0.03), Brodzinski(p=0.02) and underlying disease(p=0.002) and CSF(p=0/0009) existed.
 
Conclusion: According to the results obtained in this study, it can be concluded that pneumococcal and Haemophilus influenzae type b bacteria main cause of meningitis in children in the study, in addition to the cultivation of CSF and blood cultures correlate very poorly with results from PCR.
 
 
Keywords: Bacterial Meningitis, MULTIPLEX REAL TIME-PCR, Hemophilus Influenzae, Pneumococcus
Full-Text [PDF 2576 kb]   (136 Downloads)    
Type of Study: Research | Subject: Infectious Disease
Received: 2019/05/10 | Accepted: 2019/08/25 | Published: 2019/12/14
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Ghadimi Moghaddam A, Ghatee M, Keshtkari A, Shabankare M. Prevalence of Bacterial Causes of Meningitis and Related Factors in Patients Admitted to Imam Sajjad Hospital in Yasuj. Armaghane danesh. 2019; 24 (5) :853-864
URL: http://armaghanj.yums.ac.ir/article-1-2522-en.html


Volume 24, Issue 5 (11-2019) Back to browse issues page
ارمغان دانش Armaghane danesh
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