Early Medical Abortion with Stachys lavandulifolia Hydroalcoholic Extract in Eombination with Misoprostol Compared to Misoprostol Alone: A Randomized Clinical Trial

Aramesh , SH; Kalami,  S; Sadeghi,  H; ,

doi:10.61186/armaghanj.28.6.2

[Home ] [Archive]

[ فارسی ]

Main Menu

Home

Journal Information

Articles archive

For Authors

For Reviewers

Registration

Contact us

Site Facilities

Indexing & Abstracting

Publication Ethics

Search in website

Receive site information

Indexing & Abstracting

DOAJ
GOOGLE SCHOLAR

Volume 28, Issue 6 (12-2023)

__Armaghane Danesh__ 2023, 28(6): 743-756

Back to browse issues page

Early Medical Abortion with Stachys lavandulifolia Hydroalcoholic Extract in Eombination with Misoprostol Compared to Misoprostol Alone: A Randomized Clinical Trial

SH Aramesh¹

, S Kalami¹

, H Sadeghi²

1- Department of Gynecology and Obstetrics, Yasuj University of Medical Sciences, Yasuj, Iran
2- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

Abstract: (577 Views)

Background & aim: Considering the lack of scientific documents published on humans regarding the effect of Stachys lavandulifolia hydroalcoholic extract on abortion in traditional Iranian medicine, the aim of the present study was to determine and investigate the effect of hydroalcoholic extract of mountain tea in combination with misoprostol compared to misoprostol alone in terminating pregnancies less than 12 weeks.

Methods: The present randomized clinical trial study was conducted at Imam Sajjad Hospital of Yasuj in 2019-2020 on 40 referring patients divided into two groups. Participants were assigned to two groups of mountain tea extract in combination with misoprostol (group A) or misoprostol alone (group B). In group A, mountain tea in the form of capsules (400 mg every three hours, up to three times, daily) along with 400 micrograms of misoprostol (every three hours, up to three doses, daily) were prescribed. In group B, misoprostol 800 micrograms were taken orally every three hours, up to three doses daily. In case of no abortion, the above dose was repeated on the second day. The intended outcomes included pain intensity, bleeding intensity, patient satisfaction, type of abortion, assessment of side effects (such as vital signs, clinical symptoms, blood parameters, analysis of kidney and liver function indicators). The collected data are analyzed using chi-square and t-test.

Results: There was no statistically significant difference between the two groups in terms of complete abortion (p=0.52) and incomplete abortion (p=52). The duration of intervention in group A (6.10±1.11) was significantly shorter than group B (8.40±0.59) (p>0.001). There was no statistically significant difference between the two groups in terms of pain intensity (p=0.52) and bleeding intensity (p=0.14) at 4-8 hours and 8-12 hours after the intervention. Also, there was no significant difference between the two groups in terms of blood parameters, kidney and liver analysis (p<0.05). In terms of side effects, a statistically significant increase in fever (p=0.008), diarrhea (p<0.001) and nausea (p>0.001) was observed in group B compared to group A. Also, the results of the present study showed that patient satisfaction in group A (6±0) was significantly better than group B (4.60±1.14) (p<0.001).

Conclusion: The findings of this study indicated that S. lavandulifolia hydroalcoholic extract in combination with misoprostol resulted in shorter duration of abortion process, lower adverse outcomes and better patients’ satisfaction compared to the administration of misoprostol alone.

Keywords: S. lavandulifolia, Misoprostol, Abortion

Full-Text [PDF 614 kb] (92 Downloads)

Type of Study: Research | Subject: Gynaecology
Received: 2022/10/10 | Accepted: 2023/06/28 | Published: 2023/11/22

References

1. Lokeland M, Bjorge T, Iversen OE, Akerkar R, Bjorge L. Implementing medical abortion with mifepristone and misoprostol in Norway 1998-2013. Int J Epidemiol 2017; 46(2): 643-51.## [DOI:10.1093/ije/dyw270] [PMID] []

2. Mirmohammadi-Maibodi R, Karimzadeh-Maibodi M, Faraj khoda T, Dehghani Firooz-abadi R, Tabatabaei M. The Efficacy of Vaginal Misoprostol in Treatment of Missed Abortions. The Journal of Shahid Sadoughi University of Medical Sciences 2005; 13(3): 31-8. ##

3. Brek Jonathan S, Novaks gynecology. 13th ed. Lippincott williams and wilkins; 2002; 283. ##

4. Jafarzadeh L, Rafieian-Kopaei M, Samani RA, Asgari A. The effect of hydroalcoholic extract of Stachys lavandulifolia vahl on pregnant mice. EXCLI J 2012; 11: 357-62. ##

5. Li YT, Hsieh JC, Hou GQ, Chen TH, Chu YC, Lin TC, et al. Simultaneous use of mifepristone and misoprostol for early pregnancy termination. Taiwan J Obstet Gynecol 2011; 50(1): 11-4. ## [DOI:10.1016/j.tjog.2010.09.002] [PMID]

6. Sadi R, Mohammad-Alizadeh-Charandabi S, Mirghafourvand M, Javadzadeh Y, Ahmadi-Bonabi A. Effect of Saffron(fan hong hua) on the readiness of the uterine cervix in term pregnancy: a placebo-controlled randomized Trial. Iran Red Crescent Med J 2016; 18(10): e27241 . ## [DOI:10.5812/ircmj.27241] [PMID] []

7. Mirmohammadi-Maibodi R, Karimzadeh-Maibodi M, Faraj khoda T, Dehghani Firooz-abadi R, Tabatabaei M. The Efficacy of Vaginal Misoprostol in Treatment of Missed Abortions. The Journal of Shahid Sadoughi University of Medical Sciences 2005; 13(3): 31-8. ##

8. Lokeland M, Bjorge T, Iversen OE, Akerkar R, Bjorge L. Implementing medical abortion with mifepristone and misoprostol in Norway 1998-2013. Int J Epidemiol 2017; 46(2): 643-51. ## [DOI:10.1093/ije/dyw270] [PMID] []

9. Li YT, Hsieh JC, Hou GQ, Chen TH, Chu YC, Lin TC, et al. Simultaneous use of mifepristone and misoprostol for early pregnancy termination. Taiwan J Obstet Gynecol 2011; 50(1): 11-4. ## [DOI:10.1016/j.tjog.2010.09.002] [PMID]

10. Farnsworth NR, Bingel AS, Cordell GA, Crane FA, Fong HHS. Potential value of plants as source of new antifertility agents. II. J Pharm Sci 1975; 64: 717-54. ## [DOI:10.1002/jps.2600640504] [PMID]

11. Goonasekera MM, Gunawardana VK, Jayasena K, Mohammed SG, Balasubramaniam S. Pregnancy terminating effect of Jatropha curcas in rats. J Ethnopharmacol 1995; 47: 117-23. ## [DOI:10.1016/0378-8741(95)01263-D] [PMID]

12. Yakubu MT, Akanji MA, Oladiji AT. Evaluation of anti-androgenic potentials of aqueous extract of Chromolaena odoratum (L.) K. R. leaves in male rats. Andrologia 2007; 39: 235-43. ## [DOI:10.1111/j.1439-0272.2007.00792.x] [PMID]

13. Brinker F. Inhibition of endocrine function by botanical agents, antigonadotropic activity. Br J Phytother 1997; 4: 123-45. ##

14. Gark SK, Mathur VS, Chaundhury RR. Screening of Indian plants for anti-fertility activity. Indian J Exp Biol 1978; 16: 1077-9. ##

15. Prakash AO, Saxena V, Shukla S, Mathur R. Contraceptive potency of Puereria tuberosa D.C. and its hormonal status. Acta Eur Fertil 1985; 16: 59-65. ##

16. Morteza-Semnani K, Akbarzadeh M, Changizi S. Essential oils composition of Stachys byzantina, S. inflata, S. lavandulifolia and S. laxa from Iran. Flavour Fragr J 2006; 21: 300-3. [DOI:10.1002/ffj.1594]

17. Rechinger KH, Hedge IC. Akademiche Druck Verlagsanstalt, Graz Austria. Flora Iranica; 1982; 150, 359-61, 36. ##

18. Andalib S, Vaseghi A, Vaseghi G, Naeini AM.Sedative and hypnotic effects of Iranian traditional medicinal herbs used for treatment of insomnia.EXCLI J 2011; 10: 192-7. ##

19. Mahzooni-kachapi SS, Mahdavi M, Roozbeh-nasira'ei L, Akbarzadeh M, Rezazadeh F, Motavalizadehkakhky A. Antimicrobial activity and chemical composition of essential oils of Stachys lavandulifolia Vahl. From Mazandaran. Iran J Med Plants Res 2012; 6: 4149-58. ## [DOI:10.5897/JMPR12.734]

20. Nabavizade F, Alazadeh A.M, Adeli S, Golestan M, Kamalinejad M. Gastroprotective of Stachys lavandulifolia extract on experimental gastric ulcer. Afr. J Pharm Pharmaco 2011; 5: 155-9. ## [DOI:10.5897/AJPP10.296]

21. Ghasemi Pirbalouti A. Wound healing activity of extracts of Malvasylvestris and Stachys Lavandulifolia. Int J Biol 2011; 3: 55-62. ## [DOI:10.5539/ijb.v3n1p174]

22. Duru ME, Cakir A, Harmandar M, Izumi S, Hirata T. The volatile constituents of Stachys athorecalyx C. Koch. from Turkey. Flavour Fragr J 1999; 14: 12-4. ## https://doi.org/10.1002/(SICI)1099-1026(199901/02)14:1<12::AID-FFJ763>3.3.CO;2-Z [DOI:10.1002/(SICI)1099-1026(199901/02)14:13.3.CO;2-Z]

23. Javidnia K, Mojab F, Mojahedi SA. Chemical constituents of essential oil of Stachys lavandulifolia Vahl from Iran. Iranian J Pharm Res 2004; 3: 61-3. ## [DOI:10.1080/0972-060X.2003.10643347]

24. Sajjadi MH, Amiri H.Chemical constituents of the essential oils of different stages of the growth of Stachys lavandulifolia Vahl. from Iran.Pak J Biol Sci 2007; 10(16): 2784-6. ## [DOI:10.3923/pjbs.2007.2784.2786] [PMID]

25. Modarresi M, Hosseinzadeh L, Nematy N, Siavash-Haghighi ZM, Ghanbari K. Acute and subchronic toxicological evaluation of Stachys lavandulifolia aqueous extract in Wistar rats. Res Pharm Sci 2014; 9(3): 165-72. ##

26. Safaei A. Identification and quantitative determination of luteolin and apigenin in the aerial parts and an extract of Stachys lavandulifolia by HPLC. Iranian J Pharm Res 2004; 2: 90-2. ##

27. Le Bail JC, Varnat F, Nicolas JC, Habrioux G. Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. Cancer Lett 1998; 130: 209-16. ## [DOI:10.1016/S0304-3835(98)00141-4] [PMID]

28. Breinholt V, Hossaini A, Svendsen GW, Brouwer C, Nielsen SE. Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. Food Chem Toxicol 2000; 38: 555-64. ## [DOI:10.1016/S0278-6915(00)00046-6] [PMID]

29. Rabbani M, Sajjadi SE, Jalali A. Hydroalcohol extract and fractions of Stachys lavandulifolia Vahl: effect on spontaneous motor activity and elevated plus-maze behavior. Phytother Res 2005; 19: 854-8. ## [DOI:10.1002/ptr.1701] [PMID]

30. Butterweck V, Hegger M, Winterhoff H. Flavonoids of St. John's Wort reduce HPA axis function in the rat. Planta Med 2004; 70: 1008-11. ## [DOI:10.1055/s-2004-832631] [PMID]

31. Elbaum DJ, Bender EM, Brown JM, Keyes PL. Serum progesterone in pregnant rats with ectopic or in situ corpora lutea: correlation between amount of luteal tissue and progesterone concentration. Biol Reprod 1975; 13: 541-5. ## [DOI:10.1095/biolreprod13.5.541] [PMID]

32. Barreto RS, Quintans JS, Amarante RK. Evidence for the involvement of TNF-a and IL-1b in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-a-bisabolol, its main compound, in mice. J Ethnopharmacol 2016; 191: 9-18. ## [DOI:10.1016/j.jep.2016.06.022] [PMID]

33. Naseri MKG, Adibpour N, Namjooyan F. Spasmolytic effect of stachys lavandulifolia vahl. crude methanolic extract and fractions on rat ileum. Iran J Pharm Res 2011; 10: 307. ##

34. Nabavizadeh F, Mohammad Alizadeh A, Adeli S. Gastroprotective effects of Stachys lavandulifolia extract on experimental gastric ulcer. Afr J Pharm Pharmacol 2011; 5: 155-9. ## [DOI:10.5897/AJPP10.296]

Add your comments about this article

‎ 10.61186/armaghanj.28.6.2

Mendeley

Zotero

RefWorks

Aramesh S, Kalami S, Sadeghi H. Early Medical Abortion with Stachys lavandulifolia Hydroalcoholic Extract in Eombination with Misoprostol Compared to Misoprostol Alone: A Randomized Clinical Trial. armaghanj 2023; 28 (6) :743-756
URL: http://armaghanj.yums.ac.ir/article-1-3381-en.html

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Volume 28, Issue 6 (12-2023)

Back to browse issues page

Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4645