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:: Volume 21, Issue 8 (11-2016) ::
__Armaghane Danesh__ 2016, 21(8): 746-756 Back to browse issues page
Effect of 12 weeks aerobic exercise for along with folic acid supplementation on the levels of the ghrelin hormone amount of food intake and weight changes of female Wistar rats
A Parvizi1, A Ghasemnian 2, A Rahmani3
1- Department of Physiology, Zanjan University, Zanjan, Iran
2- Department of Sport Sciences, University of Zanjan, Zanjan, Iran , ali_59_b@yahoo.com
3- Department of Sport Sciences, University of Zanjan, Zanjan, Iran
Abstract:   (3079 Views)

Background & aim: Results of numerous studies have shown that approximately 1 to 78 percent of female athletes suffer from eating disorders. On the other hand, it has been mentioned that folic acid could increase appetite. The ghrelin hormone is known as a strong stimulant for appetite. Therefore, to clarify the role of exercise and food intake of folic acid on plasma acylated ghrelin the study aim was to evaluate the effect of 12 weeks of aerobic training on ghrelin supplementation of folic acid and quantity of food intake and weight change in female rats.

Methods: In the present experimental study, 24 rats were randomly divided into three groups of 8 including: control, training and training along with folic acid supplementation. The training protocol consisted of aerobic exercise running on a treadmill for 12 weeks (5 days a week). Standard meal and water were freely provided for the subjects and in the supplement group 10 mg dissolved folic acid per liter of water were used and then the food intake and body weight was measured every week. 24 hours after the last session of training and 8 hours of overnight fasting, blood and tissue samples were collected and hormones levels were measured using Eliza method. To data analyzing, one way ANOVA and Tukey post hoc test was used.

Results: The results showed that 12 weeks of  aerobic training with folic acid supplementation had significantly reduced serum acylated ghrelin levels (P<0.05), but no sign on stomach tissue acylated ghrelin was seen (P>0.05). The 12-week aerobic training with folic acid intake in comparison with other groups significantly increased food intake and body weight gain (p < 0.05).

Conclusion: According to the acylated ghrelin reduction and lack of change in the stomach acylated ghrelin with increased food intake and body weight in rats, it seems that taking folic acid supplements inactive athletes with another strong mechanism, increasing consumption of food and influence on appetite center.

Keywords: Aerobic training, Folic acid, Acylated ghrelin, Weight changes
Full-Text [PDF 197 kb]   (793 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2016/08/21 | Accepted: 2016/10/28 | Published: 2016/11/12
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Parvizi A, Ghasemnian A, Rahmani A. Effect of 12 weeks aerobic exercise for along with folic acid supplementation on the levels of the ghrelin hormone amount of food intake and weight changes of female Wistar rats. Armaghane danesh. 2016; 21 (8) :746-756
URL: http://armaghanj.yums.ac.ir/article-1-1474-en.html


Volume 21, Issue 8 (11-2016) Back to browse issues page
ارمغان دانش Armaghane danesh
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