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Lactate Transporters Expression in Tumor of Balb/c Mice Bearing Breast Cancer after Endurance Training
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M Aveseh   , R Nikooie , M Aminaie |
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Abstract: (4939 Views) |
| Background & aim: Changes in the metabolism of cancer cells plays a major role in the survival and their expansion. The aim of this study was to determine expression of lactate transmitters in Balb/c mice with breast cancer after endurance training.
Methods: In this experimental study twenty-five Balb C mice were randomly divided into two groups of breast cancer control (N=13) and breast cancer training (N=12). Breast cancer was induced in mammary fat pad by injection of cancer cells (MC4L2) in mice and endurance training protocol was applied for 7 weeks in the experimental group. Tumor volume and MCT1, MCT4, and CD147 expression were measured by micro digital caliper and western blotting technique respectively. Data were analyzed statistically using Student t and Pearson.
Results: Significant decreases was found in weight and CD147 expression of tumor after 7 weeks of endurance training in the exercise group compared to the control group. No significant differences were seen in MCT4 expression and tumor volume between the groups (05 / 0p>0.05). Significant correlation was found between tumor MCT1 and CD147 expression (P < 0.05), while the relationship between MCT4 and CD147 expression in tumors was not statistically significant.
Conclusion: Endurance training can reduce lactate metabolism in cancer cells through suppression of lactate transporters expression and provides a useful tool in breast cancer treatment or prevention. |
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| Keywords: Endurance training, Breast cancer, Lactate, Monocarboxylate transporters |
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Full-Text [PDF 355 kb]
(1902 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/04/7 | Accepted: 2015/04/7 | Published: 2015/04/7
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