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:: Volume 20, Issue 3 (6-2015) ::
__Armaghane Danesh__ 2015, 20(3): 220-229 Back to browse issues page
Leptin and Pathological Indexes in Women with Breast Cancer
B Noori Alavicheh1, R Mahmoudi2, H Abidi2, A Azizi2, MA Nazer Mozaffari2, M Fararooei3, Z Rezaei2, M Nikseresht 4
1- Student Research Committee,Yasuj University of Medical Sciences,Yasuj, Iran
2- Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Iran
3- 3HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Iran , nikmohsen@yahoo.com
Abstract:   (2083 Views)
Background & aim: Breast cancer is the most common cancer among women and one of the factors threatening the health of women worldwide. Leptin is a 16 kD glycoprotein hormone produced predominantly by white adipose tissue. Leptin binds to receptors in the hypothalamus and plays a key role in regulation of metabolism. Both leptin and leptin receptor have recently been implicated in processes and progress leading to breast cancer initiation. The aim of this study was to identify if there is association between leptin and pathological indexes in patients with breast cancer Methods: 45women with breast cancer were enrolled. Serum leptin levels of patients were measured by the ELISA method. Pathological information such as stage of the breast cancer, Hormonal receptor (ER, PR) and Her2 status in these patients were determined. Result: Results revealed that the patients who were in stage one and two, the mean serum leptin level was (34.18±21.22 ng/ml) And patients who were in stage three and four, the mean serum leptin level was (32.21±21/93 ng/ml). Also the mean serum leptin levels in patients whose receptor status of ER, PR and HER2 positive were (35.90±23.55, 35.74±23.91and 37.02±24.25ng/ml), respectively. The Patients whose receptor status of ER, PR and HER2 negative were 26.64±13.13, 28.17±14.26and31.32±19.9ng/ml respectively. No significant association was found between leptin leveland stage of the breast cancer, hormonal receptor (ER, PR) and Her2 status in Patients with Breast cancer(p>0.05). Conclusions: In this study, no association was found between serum leptin level and pathological indices in women with Breast cancer in Yasuj, Iran.
Keywords: Breast Cancer, Leptin, Pathological Indexes
Full-Text [PDF 168 kb]   (965 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/05/31 | Accepted: 2015/05/31 | Published: 2015/05/31
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Noori Alavicheh B, Mahmoudi R, Abidi H, Azizi A, Nazer Mozaffari M, Fararooei M, et al . Leptin and Pathological Indexes in Women with Breast Cancer. Armaghane danesh. 2015; 20 (3) :220-229
URL: http://armaghanj.yums.ac.ir/article-1-632-en.html


Volume 20, Issue 3 (6-2015) Back to browse issues page
ارمغان دانش Armaghane danesh
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