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Comparison of the Therapeutic Efficacy of Azithromycin vs Tetracycline in Acne Vulgaris
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F Rad   1, R Yaghmaee , E Ghaderi |
| 1- , dr_farokh_rad @yahoo.com |
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Abstract: (7433 Views) |
| ABSTRACT:
Introduction & Objective: Acne vulgaris is a common skin disease which affects a large number of adolescents and adults at some time in their life. Several drugs have been used for the treatment of acne vulgaris and recently systemic azithromycin has been tried for its treatment. The aim of this study was to compare the therapeutic efficacy of azithromycin vs. tetracycline in acne vulgaris.
Materials & Methods: The present study was a randomized investigator-blind clinical trial, carried out at the outpatient department of Besat Hospital of Sanandaj in 2008. 82 patients were allocated randomly into two groups. Azithromycin 500 mg for 3 consecutive days per week for the first month, then 250 mg/ every other day was prescribed for the first group .The second group received tetracycline 250 mg/6h .The treatments continued for 12 weeks. The therapeutic efficacy of these drugs was assessed on the basis of lesion counting. Data were introduced into SPSS 11.5 software and analyzed by means of independent t- test, Mann-Whitney and chi-square test.
Results: The mean number of lesions was not statistically different before treatment in the two groups. There was statistically a significant difference in the mean number of inflammatory papular lesions on the face and back after treatment (p<0.05). However no significant difference was found in comedons lesions in both groups. The percentages of improvement of inflammatory papular lesions on the face and back were 82.3, 63.6 and 80.14 and 58.56 respectively (p<0.05).
Conclusion: This study suggested that azithromycin was more effective than tetracycline in treating inflammatory papular lesions of acne vulgaris on the face and back. Azithromycin can be used as an alternative in the treatment of resistant inflammatory papular lesions to tetracycline.
Keywords: Azithromycin, Acne Vulgaris, Tetracycline |
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| Keywords: Azithromycin, Acne Vulgaris, Tetracycline |
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Full-Text [PDF 118 kb]
(1243 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/05/30 | Accepted: 2015/05/30 | Published: 2015/05/30
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