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Effects of Cinnamon Extract on Cerebellum Histomorphometry in Diabetic Rats’ Fetus
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AR Rafati   1, SS Hashemi , O Hashemi |
| 1- , rafati@iausarv.ac.ir |
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Abstract: (6725 Views) |
| Abstract
Background & aim: In pregnant women, maternal diabetes occurs when the pancreas does not produce enough insulin, so glucose increases in the mother's blood and the blood of the fetus therefore causing many complications in children. The aim of this study was to evaluate the effects of cinnamon on morphometric histologic changes on fetal cerebellum of diabetic rats at days 18 and 20.
Methods: In this study, 32 healthy female Wistar rats were prepared and randomly divided into four groups, normal control, diabetic, healthy subjects treated with cinnamon and cinnamon extract-treated diabetic groups. Diabetic groups were subjected by intraperitoneal of streptozotocin. All groups were charged with natural mating and they received a dose of 60 mg/ kg of cinnamon at the first day off pregnancy. After formation of the nervous system, in the eighteenth and twentieth day of pregnancy, the mother of the four mice were anesthetized and the fetus was removed for sampling. The histological slides were prepared and various parameters were studied in the cerebellum. Data were analyzed using one-way ANOVA and Duncan test.
Results: The thickness of gray matter, and the gray matter white cells in the cerebellum of diabetic rats compared to other groups tested at days of18 and 20 and embryonic cells in the white matter of the cerebellum at day 18 was significantly decreased (p< 0.05).
Conclusion: Administration of cinnamon extract reduces mothers’ blood sugar levels therefore preventing the complications of diabetes on the fetal cerebellum.
Key words: cinnamon extract, Diabetes, cerebellum, Rat. |
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| Keywords: Key words: cinnamon extract, Diabetes, cerebellum, Rat. |
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Full-Text [PDF 1844 kb]
(1938 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/04/15 | Accepted: 2015/04/15 | Published: 2015/04/15
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