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Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney
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A Fakourian1    , H Matinhomaee2 , MA Azarbayjani1 , P Farzanegi3 |
1- Department of Physical Education and Sport Science, Islamic Azad University, Central Tehran Branch, Tehran, Iran
2- Department of Physical Education and Sport Science, Islamic Azad University, Central Tehran Branch, Tehran, Iran , hasanmatinhomaee@yahoo.com
3- Department of Physical Education and Sport Science, Islamic Azad University, Sari Branch, Sari, Iran |
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Abstract: (4759 Views) |
Abstract
Background & aim: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and consumption of l-carnitine on some of the oxidative stress factors in diabetic kidney.
Methods: In the present experimental study, 45 male Wistar rats(200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving l-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving l-carnitine. Rats were diabetic peritoneal injected with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily of 100 mg of l-carnitine orally. The aerobic exercise protocol included five sessions per week on the treadmill. Data were analyzed by two way ANOVA and Tukey post hoc test at P <0.05.
Results: Six weeks of aerobic exercise, supplementation of l-carnitine and combined intervention of aerobic exercise and supplementation of l-carnitine do not have a significant effect on MDA and SOD factors of kidney tissue in diabetic rats(p>0.05). However, six weeks of aerobic exercise had a significant effect on GPX factor in kidney tissue in diabetic rats (p=0.003). Moreover, supplementation and combined intervention of aerobic exercise and supplementation of l-carnitine did not have a significant effect on GPX factor of kidney tissue in diabetic rats (p>0.05)
Conclusion: L-carnitine supplementation intake with regular exercise can have beneficial effects on the body, antioxidant defense system and decreases oxidative stress in rats with type 2 diabetes.
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| Keywords: Aerobic training, L-carnitine, Diabetes, SOD, GPX, MDA, Kidney |
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Full-Text [PDF 166 kb]
(950 Downloads)
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Type of Study: Research |
Subject:
Sport Physiology
Received: 2018/12/24 | Accepted: 2019/04/7 | Published: 2019/07/6
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