1 1728-6506 Yasuj University Of Medical Sciences 2090 Neonatology & Newborn Nursery- NICU-Surgery The effect of Self-Care Program Using Orem’s Self- Care Model on the Life Quality of Women with Breast Cancer Undergoing Chemotherapy: A Randomized Controlled Trial Afrasiabifar A b Hamzhiekia SH c Hosseini NA d b School of Nursing, Yasuj University of Medical Sciences, Yasuj, Iran, c Student Research Committee,Yasuj University of Medical Sciences, Yasuj, Iran d School of Nursing, Yasuj University of Medical Sciences, Yasuj, Iran, 1 4 2018 23 1 1 13 28 01 2018 24 02 2018 Background & Aim: Diagnosis and treatment of breast cancer can have a detrimental effect on the quality of life of women. Self-care program seems necessary to improve their quality of life. The aim of this study was to examine the effect of Orem self-care model on the quality of life of women with breast cancer.   Methods: In this clinical trial, eighty women with breast cancer who who referred to oncology centers affiliated to Shiraz University of Medical Sciences. The sampling method was as convenience method but selected samples were randomly assigned between the control and intervention groups. Orem's self-care model was taught to patients of intervention group during an eight sessions about forty-five minutes. The QLQ-C30 and QLQ-BR23 questionnaires were used to collect data before intervention and two weeks after the last intervention session. Data were analyzed by SPSS software version 21 through descriptive and inferential statistics, taking into account the significance level.   Results: Significant statistical differences were reported among the sub-scales of quality of life namely global health status, physical functioning, emotional functioning, and role functioning, social functioning, body image and future perspective between the two groups after intervention. The median test has shown a significant difference (p <0.05) by the number of patients in the test group who had a higher scores than the overall median , i.e., improvement in the quality of life , compared to the number of patients in the control group. Also, the results of the study about symptoms scales/items showed that the number of patients in the test group who had equal to or less than the total median score of fatigue, nausea and vomiting, insomnia, anorexia, constipation, systemic therapy side effects, arm symptoms, breast symptoms, and upset by hair loss, i.e., improvement in the quality of life, had a significant difference compared to those in the control group (p <0.05). However, no significant difference was observed by subscales of cognitive functioning, sexual functioning and sexual enjoyment, as well as symptoms such as pain, dyspnea, diarrhea and financial difficulties between the two groups of test and control (p>0.05).   Conclusion: Orem's self-care model has been able to improve the quality of life of women with breast cancer by reducing some of the symptoms associated with their illness and treatment.  
1923 Clinical The effect of Wheat Germ Oil on Liver Damage Induced by Carbon Tetrachloride in Adult Male Rezazadeh F e Nejati V f Shalizar Jalali A g Najafi GH h Rahmani F i e Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran f Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran g Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran h Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran i Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran 1 4 2018 23 1 14 28 03 09 2017 21 01 2018 Background& Aim: Carbon tetrachloride as a solvent and chemical intermediate used in the industry can cause several side effects, including liver toxicity. The aim of this study was to evaluate the potential hepatic protection of wheat germ oil against tetrachloride-induced liver disorders in male rats. Methods: In this experimental study, 48 male mice were randomly divided into 6 groups of 8 and treated for 4 weeks including control, carbon tetrachloride (1 ml/kg body weight intraperitoneally, 2 times a week),carbon tetrachloride (1 ml/kg body weight intraperitoneally) + wheat germ oil (250 mg/kg body weight per day orally), carbon tetrachloride (1 ml/kg) + wheat germ oil (500 mg/kg/day orally), wheat germ oil (250 mg/kg body weight per day orally) and wheat germ oil (500 mg/kg body weight per day orally) groups. At the end of the treatment period, blood samples were collected for measurement of liver enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). Isolated hepatocyte specimens were fixed with 10% formalin and then stained with hematoxylin and eosin and analyzed by light microscopy. Data were analyzed by one-way ANOVA and Tukey's post hoc test. Results: In rats receiving carbon tetrachloride combined with wheat germ oil (250 and 500 mg / kg), liver enzymes (ALP, ALT, AST) significantly decreased (P <0.05) compared to the carbon tetrachloride group. Lipid peroxidation in carbon tetrachloride + wheat germ oil (250 and 500 mg / kg) compared to the carbon tetrachloride group significantly (p <0.05) decreased and the levels of catalase and total antioxidant capacity (P <0.05) (p) increased. Also, wheat germ oil in doses of 250 and 500 mg / kg improved the tissue damage caused by tetrachloride. Conclusion: According to the findings of this study, wheat germ oil appears to have a protective effect on liver toxicity due to tetrachloride in rats.  Carbon Tetrachloride, Wheat Germ Oil, Liver, Oxidative Stress, Mice 1887 Special The Healing effect of Teucriumpolium L. on Acetic Acid-Induced Colitis in Male Rat Toneedeh N j Lashkarpoor HA k Daneshchi S l Asadi Yousefabad SL m Koohi-Hossein Abadi O n Hosseinzadeh M o Jamshid Zadeh A p Mohammadi Samani S Omidi M j Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran k Drug Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, l Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, m Student Research Committee, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran n Laboratory Centers, Shiraz University of Medical Sciences, Shiraz, Iran, o Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran, p Drug Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Drug Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Department of Pharmacology and Toxicology, Hormozgan University of Medical Sciences, Bandar Abbas , Iran 1 4 2018 23 1 29 41 23 07 2017 07 02 2018 Background & aim: Inflammatory bowel disease (IBD) as a chronic condition of the intestine with unknown etiology involving different agents like immune, genetic and environment. Today, many of herbal and synthetic compounds are being used as anti-inflammatory products around the world. The aim of this study was to investigate the anti-inflammatory effect of aquatic extraction of Teucrium polium L. plant on colitis in rat. Methods: In this experimental study, a total of 135 male rats, weighing 200±20 g and 10  to 12 weeks old, were randomly divided into nine equal groups: healthy control group were given normal saline without ulcerative colitis (UC) induction, negative control group which UC was induced by 3% acetic acid with no treatment, basal gel group which were received basal gel via enema after UC induction, two groups as positive controls were taken Asacol (10 mg/kg/day) and Mesalamine (10 mg/kg/day) trans-rectally and orally, respectively. Also, oral form of aqueous extraction with doses of 50 and 100 mg/kg/day in two groups and enema form (gel 10% and 20%) of Teucrium polium L. in two groups were given. At the end of study, MDA measurement as antioxidant index and histopathological evaluation of colon tissue were performed. The collected data were analysed using one-way ANOVA and Mann–Whitney U test.   Results: Enema gels 10% and 20% lead to repair of damaged tissue of colon at the microscopic level and caused reduction in MDA level (p<0.01). Gels 20% compared with negative control showed significant difference in in terms ofMDA (p<0.01). Mesalamine and Asacol as positive controls, compared with each other and alsooral and enema forms of Teucrium polium L. showed no significant difference in respect of MDA (p<0.01). Although, enema gel form compared with oral form of plant aquatic extraction showed no significant difference, but enema form had better effect in control of inflammation.       Conclusion: Teucrium polium L. has remarkable effects on healing processing of induced colitis in male rat. According to anti-inflammation, antioxidant and anti-microbial properties of Teucrium polium L., it can be mentioned that this plant is effective in healing of intestinal ulcers.     1926 Immunology Effect of Mesenchymal Stem Cells treated with 17β-estradiol on the Pattern of Intrinsic Immunity Responses in Collagen-Induced Rheumatoid Arthritis in Wistar Rats Jahan Tigh M Abtahi Froshani SM Afzal Ahangaran N Department of Microbiology, Urmia University, Urmia, Iran Department of Microbiology, Urmia University, Urmia, Iran Department of Microbiology, Urmia University, Urmia, Iran 1 4 2018 23 1 42 56 04 09 2017 12 12 2017 Background and Aim: So far, no information has been found on the role of estradiol in altering the immunosuppression of immune system in the in vitro model. The aim of the present study was to evaluate the effects of treatment with 17-beta estradiol MSCs in the regulation of intrinsic immune responses in rheumatoid arthritis (RA) animal models.   Methods: In this experimental study, mesenchymal stem cells were admixed with 17 β-estradiol (E2 100 μM) for 24 hours, and rheumatoid arthritis was induced by collagen and complete perfusion adjuvant in Wistar rats. One week After immunization, rats in untreated groups treated with MSCs without treatment (intraperitoneal injection of two million cells), treated with MSCs treated with E2, changing the diameter of the wrists and the foot of each rat until day 33 After induction, the disease was recorded every 5 days. Data were analyzed by one-way ANOVA and one-way ANOVA. Which were analyzed.   Results: The amount of edema and swelling of the palms of the hands and feet on the last day was positive in the control group (5.9 ± 0.6 mm) more than the treatment groups. Inflation rate in the treated group with E2 treated MSCs (1.69 ± 0.45 mm) was significantly lower than that treated with MSCs without treatment (2.96 ± 0.3 mm). Also, the respiratory burst ability (1. 57 ± 0.11), the amount of phagocytosis (0.11 ± 0.90) and the nitric oxide production (219.66 ± 8.18 μmol / L) in the intrinsic immune cells of the spleen in The positive control group was more than the control group. The rate of respiratory burst, phagocytosis and nitric oxide production in treated MSCs were (0.79 ± 0.99, 0.61 ± 0.08, 155.9 ± 13.29 μM), respectively, and in The group receiving untreated MSCs was 0.99 ± 0.08, 0.88 ± 0.07 and 18.79 ± 12.18 μM respectively.   Conclusion: Treatment of MSCs with 17 beta-estradiol increases regulatory function and inhibitory effect on inflammatory mediators of spleen inherent immune cells in the RA model compared to non-treated mesenchymal stem cells.   1575 Physiology Effect of Aqueous Extract of Cinnamon on Anxiety-Like Behavior in Streptozotocin-Induced Diabetic Male Rats Mohammadzadeh M Sharifzadeh S Ilkhanipoor M Nejati V Heidari R Department of Biology, Urmia University, Urmia, Iran Department of Biology, Urmia University, Urmia, Iran Department of Biology, Urmia University, Urmia, Iran Department of Biology, Urmia University, Urmia, Iran Department of Biology, Urmia University, Urmia, Iran 1 4 2018 23 1 57 68 10 04 2017 23 02 2018 Background & Aim: Nowadays, the use of herbal products as supplementary or substitute chemical drugs in the treatment of diseases has been associated with low side effects and cost of treatment. The aim of this study was to evaluate the effect of cinnamon aqueous extract on anxiety-like behavior of streptozotocin-induced diabetic male rats.   Methods: In this experimental study, 28 male Wistar rats weighing approximately 200±30 g were used in four groups of seven. For induction of diabetes mice, intraperitoneal injection of 50 mg / kg streptozotocin was used. The experiments were designed for 3 weeks. During this period, the treatment was performed by cinnamon extract at a concentration of 200 mg / kg orally. At the end, recording and evaluation of the anxiety behavior evaluation indicators of mice including duration of presence and The number of access times in the open arms is performed at a set time interval for a period of 5 minutes with a plus maze device. Data were analyzed by one-way ANOVA and Tukey's post hoc test.   Results: There was no significant difference in the duration of presence in the open arms of the elevated plus maze (EPM) between healthy rats receiving cinnamon extract. Also, the results showed that the duration of presence in the open arms of the maze in the control rats Diabetic and diabetic recipients of cinnamon extract were significantly less than healthy ones. The results showed that the duration of presence in the open arms of maze in diabetic control and diabetic rats receiving cinnamon extract was significantly lower from healthy groups (controls and recipients of cinnamon extract). In general, increased anxiety behaviors in diabetic rats Indicates anxiety levels in diabetic rats treated with a small extract compared to diabetic control group, but this is not statistically significant (P≤0.05).   Conclusion: Cinnamon extract has no effect on anxiety and anxiety-like behaviors due to decreased blood glucose. Therefore, it can be suggested that on the one hand, the concentration of cinnamon used to treat diabetic rats is not sufficient to reduce blood glucose and has no effect on the performance of anesthetic neurotransmitter systems.   2006 Parasitology Investigation of the effects of Ceratonia Silique Extract on Protoscolexes of Hydratid Cyst in Vitro Malekifard F Keramati F Department of Pathobiology, Urmia University, Urmia, Iran Department of Pathobiology, Urmia University, Urmia, Iran 1 4 2018 23 1 69 79 20 11 2017 06 02 2018 Background and Aim: It is difficult to use chemical drugs to treat  of hydatid cyst due to their different side effects. Therefore, today, the use of non-chemical compounds such as medicinal plants is considered as a method of treatment against hydatid cyst. The aim of the present study was to investigate the effect of scoliosis of clove extract in invitro.   Methods: In this experimental study, different concentrations of clove extract at various times in experimental conditions were investigated to evaluate its effects on hydatid cyst. Protoscolexes were completely sterilized from hydatid cyst infected sheep liverand exposed to 3 concentrations of clove extract (10, 25 and 50 mg / ml) for for 10, 20, 30 and 60 minute. The survival of protoscolexes was determined with 0.1% eosin staining. The collected data were analyzed by statistical tests.   Results: Based on our results, the scolicidal effects of this plant on Hydatid Cysts in all concentrations was significant compared to the control groups (p<0.05). Carob extract at concentration of 50 mg/ml destroyed all protoscolices in 30 min.   Conclusion: The results also showed that the extract of this plant produce high scolicidal activity; However, in vivo efficacy of this medicinal plant remains to be studied for treatment of hydatid cysts in humans and herbivorous animals.     1610 Special The Effect of Abelmoscus Esculentus Powder on Histological Changes of the Ovary in Diabetic Rats Erfani majd N Aziziyan H Tabandeh MR Shahryari A Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran, Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran, Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran 1 4 2018 23 1 80 98 05 05 2017 16 02 2018 Background & Aim: Diabetes mellitus is the most common endocrine disorder in the world which causes ovarian dysfunction. The aim of this study was to evaluate the effect of omelette powder on ovarian tissue changes in diabetic rats using a high-fat diet based on streptozotocin HFD / STZ.   Methods: In this experimental study, 25 female rats (Wistar rats) were divided into 5 groups of 5. The first group, as the control group, the second group was received high-fat diet (HFD) (fat 60% + 25% carbohydrate + protein 15%), followed by STZ (35 mg / kg) intravenous 4 weeks. the third group received diazepam (200 mg / kg), the fourth group received metformin (200 mg / kg), the fifth group as sham or the control group of healthy rats (200 mg / kg) received only Abelmoschus esculentus powder. After 4 weeks of treatment the animals were euthanized body weight, ovary weight and insulin resistance markers (levels of insulin, glucose and HOMA-IR) were measured. From the right ovary sections  of 5 to 6 micrometers in diameter were prepared, stained and then studied.Data were analyzed using ANOVA and LSD tests.   Results: Hyperglycemia, insulin resistance and reduced body weight of diabetic rats were improved after administration of Abelmoscus esculentus powder in duration of 4 weeks. This effect was relatively similar to metformin. Abelmoscus esculentus powder was caused a significant increase in primordial, primary and graffian follicles (P<0.05) and early corpus luteum. A significant reduction were seen also in the preantral and antral follicle atresia (P<0.05) and old corpus luteum in ovary of diabetic rats.   Conclusion: The results of this study showed that Abelmoscus esculentus powder with its antioxidant activity and other properties has a correlation function on hyperglycemia and suitable intermediates for the improvement of ovarian disorders in diabetic rats.       2031 General Evaluation of the Quality of Health Care Services After Implementation of the Plan for the Development of Health System in Yasuj Hospitals Mohammad Hosseini Servak R Sajadikhah Gh Social Determinant of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran, Department of Development Management, Yasooj Branch, Islamic Azad University, Yasooj, Iran 1 4 2018 23 1 99 111 10 12 2017 06 02 2018 Background and Aim: Health system development plan has eight steps in the government response to vulnerable demands in the health sector in the community. The quality of services is an important factor for the growth, success and survival of the organization. Therefore, the purpose of this study was to review the health care quality after apply health system in yasuj city hospitals.   Methods: The population of this descriptive study were 380, 150, and 300 patients in Shahid Beheshti, Shahid rajaee  and imam sajjad hospital respectuively. according to Morgan table  181 patients in Shahid Beheshti hospital, 108 patients shahid rajaee hospital and 169 patients in imam sajjad hospital were selected as samples. All subjects filled out health system design and quality of treatment services questionnaires. For statistical analysis of data used Pearson correlation coefficient and regression tests (p≤0.05).   Results: There was a significant relationship between the health system and the quality of health care services (p=0.001). Also quality of health care has significant relationship with reducing the amount paid of patients (p=0.001), supporting the survival of physicians in deprived areas (p=0.001), the presence of specialist physicians residing in public hospitals (p=0.001), improving hoteling quality in hospitals (p=0.001) and improving the quality of the services of visiting hospitals (p=0.001) in the hospitals of Yasuj.   Conclusion: It appears that health care quality after apply health system improved in yasuj city hospitals.     1903 Psychology Relationship Between Attachment to God with Psychological Wellbeing and the Mediating Role of Shame and Guilt Khoramrooz SJ Moltafet G Firoozi M Department of psychology, Yasouj University, Yasouj, Iran Department of psychology, Yasouj University, Yasouj, Iran Department of psychology, Yasouj University, Yasouj, Iran 1 4 2018 23 1 112 123 07 08 2017 02 03 2018 Background & Aim:  Well-being is a kind of positive feeling and general satisfaction of oneself and others in different areas having high welfare could lead to a more dynamic community. The purpose of this study was to investigate the relationship between attachment to God and psychological well-being due to the feeling of shame and sin.   Methods: The present study is a descriptive and correlational study carried out in the form of structural equations. The statistical population of which 284 students (120 boys and 164 girls) were selected by multi-stage random cluster sampling and were assigned to Krik Patrick's Attention Attachment Inventory (ATGI), Welfare Questionnaire Psychological (QEWB) Alan Watterman and GASP Questionnaire. data analysis by using of SPSS and ,Amos Software.   Results: Results of structure equation model showed that the measurement model had a good fitness with data and the results of structure model showed that attachment on God had a positive effect on psychological wellbeing and sense of shame and guilt. Also, the results of structural model showed that psychological well-being is influenced by attachment to God and feeling of shame and sin. So that the attachment to God directly affects the quality of well-being and with the coefficient 55%. It also affects the feeling of shame and sin. Also, the feeling of shame and sin negatively affects psychological well-being with coefficient 70% and the feeling of shame and sin can play a mediating role   Conclusion: These findings will make us aware of the factors of attachment to God and the feelings of sin and shame that affect well-being, and attachment to God can lead to increased psychological well-being.     1992 Educational health Measuring Nutritional Literacy in Elementary School Teachers in Yasuj: A Cross-Sectional Study Hemati M Akbartabar Toori M Shams M Behroozpour A Rezaei A Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Department of Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Department of Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran 1 4 2018 23 1 124 133 09 11 2017 16 02 2018 Background & Aim: Nutritional literacy is the capacity of people to gain, understand and evaluate nutritional information for proper nutrition decision making. This research has been designed and implemented to measure the nutritional literacy of primary school teachers in Yasuj   Methods: This cross-sectional study was performed on two parts of the nationalization of the Nutrition Literacy Instrument developed in Turkey, as well as nutritional literacy assessment in elementary school teachers in Yasuj. The selected instrument was localized using translate translation method and receiving and applying opinions of nutritionists specialist on the structure and content of the questionnaire, and then ensuring its reliability for use in Iranian society. Nutritional literacy data were collected from a group of 110 elementary teachers in Yasouj who were selected by multi-stage cluster sampling through a self-administered questionnaire and then analyzed by descriptive and analytical statistics.   Results: The localized nutritional literacy tool had 35 items and the Cronbach's alpha coefficient was 0.73. Mean and standard deviation of teacher's score from the nutritional literacy tool was 27.14 ± 3.2, which indicated that 22.7% of teachers had inadequate nutritional literacy. Teachers with fewer years of work and higher education had a higher level of nutritional literacy. The lowest percentages of responses were related to the skill of determining food units, doing calculations and reading food labels.   Conclusions: Majority of the teachers studied had sufficient nutritional literacy, but defect in three parts of the skill of determining food units, doing calculations and reading food labels indicates the need to pay attention to these components in the design and implementation of nutrition improvement programs.