fa تأثیر استفاده از کدو بر درمان کبد چرب غیرالکلی و بروز دیابت بارداری در زنان باردار بالینی-زنان و زایمان Gynaecology پژوهشي Research <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">زمینه و هدف:</span></span></span></b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black"> کدو گیاهی دارای خواص دارویی در درمان انواع اختلالات متابولیک می‌باشد که علی‌رغم اثربخشی خوب، هنوز در مورد کاربرد آن در دوران بارداری اتفاق نظر وجود ندارد. لذا هدف از این مطالعه تعیین و بررسی تأثیر </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">استفاده از کدو بر درمان کبد چرب غیرالکلی و بروز دیابت بارداری در زنان باردار بود.</span></span></span><span dir="LTR" style="font-size:10.0pt"><span arial="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:0in 35.4pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black"></span></span></span></b></span></span></span></span></span></span></span></span> <pre dir="RTL" style="text-align:justify"> <span style="font-size:10pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span courier="" new="" style="font-family:"><b><span lang="FA" style="font-family:Yagut"><span style="color:black">روش بررسی: </span></span></b><span lang="FA" style="font-family:Yagut"><span style="color:black">در این مطالعه که به صورت کارآزمایی بالینی تصادفی &nbsp;در سال 1396 انجام شد، 60 خانم باردار مبتلا به کبد چرب غیرالکلی انتخاب و به صورت تصادفی به گروه دریافت کننده رژیم غذایی به همراه کدو به میزان 100 گرم به مدت 6 هفته و گروه دریافت کننده رژیم غذایی به تنهایی تقسیم شدند. شاخص‌های متابولیک سرمی، گرید کبد چرب، سونوگرافی </span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">B-Mode</span></span></span> <span lang="FA" style="font-family:Yagut"><span style="color:black">و دیابت بارداری بین دو گروه مقایسه گردید. داده‌های جمع‌آوری شده با استفاده از آزمون‌های آماری کلموگروف ـ اسمیرنوف، آنالیز واریانس، مجذور کای، تی‌تست، ویلکاکسون، مک‌نمار و مجذور کای </span></span><span lang="AR-SA" style="font-family:Yagut"><span style="color:black">تجزیه و تحلیل شدند.</span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></pre> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:0in 35.4pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black"></span></span></span></b></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:0in 35.4pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">یافته‌ها:</span></span></span></b> <span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">نتایج بررسی حاضر نشان داد شاخص‌های متابولیک </span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">ALT</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">، </span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">AST</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black"> ، </span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">ALP</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black"> ، </span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">LDL</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">، </span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">Chol</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">، پس از انجام مداخله بین دو گروه مداخله و کنترل اختلاف معنی‌داری داشته‌اند(05/0></span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">p</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">).</span></span></span> <span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">&nbsp;مقایسه گرید کبد چرب بعد از انجام مداخله بین دو گروه اختلاف آماری معنی‌داری را نشان نمی‌داد(05/0</span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">p></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">). میزان تغییرات در سونوگرافی </span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">B-Mode</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black"> بعد از درمان در هر دو گروه مداخله(001/0=</span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">p</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">) و شاهد(046/0=</span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black">p</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">) معنی‌دار بود.&nbsp;&nbsp; </span></span></span><span dir="LTR" style="font-size:8.0pt"><span arial="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black"></span></span></span></b></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">نتیجه‌گیری: </span></span></span></b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black">بر اساس نتایج به دست آمده چنین استنباط می‌شود که استفاده از کدو در مادران باردار تأثیری متفاوت از دارونما در درمان کبد چرب غیرالکلی و بر روی میزان بروز ابتلا به دیابت بارداری ندارد، لذا استفاده از آن به این منظور توصیه نمی‌شود.</span></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:10.0pt"><span style="font-family:Yagut"><span style="color:black"></span></span></span></b></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span arial="" style="font-family:"><span style="color:black">Background & aim:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span arial="" style="font-family:">Pumpkin plant has medicinal properties in the treatment of various metabolic disorders, which despite its good effectiveness, there is still no consensus on its use during pregnancy. Therefore, the purpose of the present study was to determine and investigate the effect of using pumpkin on the treatment of non-alcoholic fatty liver disease and the occurrence of gestational diabetes in pregnant women.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><span style="font-size:10.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span arial="" style="font-family:">Methods</span></span></b><span style="font-size:10.0pt"><span arial="" style="font-family:">: In the present study conducted as a randomized clinical trial in 2016, 60 pregnant women with non-alcoholic fatty liver disease were selected and randomly assigned to the group receiving the diet with pumpkin in the amount of 100 grams for 6 weeks and the group Diet recipients were divided alone. Serum metabolic indices, fatty liver grade, B-Mode ultrasound and gestational diabetes were compared between the two groups. Collected data were analyzed using Kolmogorov-Smirnov statistical tests, analysis of variance, chi-square, t-test, Wilcoxon, McNemar and chi-square.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><span style="font-size:10.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span arial="" style="font-family:">Results</span></span></b><span style="font-size:10.0pt"><span arial="" style="font-family:">: The results of the present study indicated that the metabolic indices of ALT, AST, ALP, LDL, and Chol had a significant difference between the intervention and control groups after the intervention (p<0.05). The comparison of fatty liver grade after the intervention did not show a statistically significant difference between the two groups (p>0.05). The amount of changes in B-Mode ultrasound after treatment was significant in both intervention (p=0.001) and control (p=0.046) groups. The point of the findings should be written in more detail, it is very dumb and incomprehensible</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><span style="font-size:7.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span arial="" style="font-family:">Conclusion</span></span></b><span style="font-size:10.0pt"><span arial="" style="font-family:">: Based on the obtained results, it was concluded that the use of pumpkin in pregnant mothers did not have a dissimilar effect than the placebo in the treatment of non-alcoholic fatty liver and on the incidence of gestational diabetes, so its use is not recommended for this purpose.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><span style="font-size:6.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span><br> &nbsp; کبد چرب, دیابت بارداری, کدو Fatty liver, Gestational diabetes, Pumpkin 540 550 http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-2087-2&slc_lang=fa&sid=1 N Najdi نازیلا نجدی najdi@arakmu.ac.ir 100319475328460027060 100319475328460027060 No Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran گروه زنان و مامایی، دانشگاه علوم پزشکی اراک، اراک، ایران M Jamilian مهری جمیلیان jamilian.mehri@gmail.com 100319475328460027061 100319475328460027061 No Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran گروه زنان و مامایی، دانشگاه علوم پزشکی اراک، اراک، ایران R Haghjoo راحیل حق جو rahilhaghjoo1@gmail.com 100319475328460027062 100319475328460027062 No Department of Anatomical Sciences, Zoonosis Research Center, Jahrom University of Medical Sciences, Jahrom, Iran گروه علوم تشریح، مرکز تحقیقات زئونوز، دانشگاه علوم پزشکی جهرم، جهرم، ایران A Haghjoo آناهیتا حق جو Anahita.haghjoo88@gmail.com 100319475328460027063 100319475328460027063 Yes Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran گروه زنان و مامایی، دانشگاه علوم پزشکی اراک، اراک، ایران