Armaghane Danesh
ارمغان دانش
armaghanj
Medical Sciences
http://armaghanj.yums.ac.ir
1
admin
1728-6506
1728-6514
10.61882/armaghanj
en
jalali
1398
4
1
gregorian
2019
7
1
24
3
online
1
fulltext
fa
تأثیر تمرین ترکیبی بر سطوح آپلین، اینترلوکینـ6 و پروتئین واکنشی ـ Cدر مردان میانسال چاق کمتحرک
The Effect of Concurrent Training on Apelin, Interleukin-6, and C - reactive protein levels in Middle-Aged Sedentary Obese Men
فیزیولوژی ورزش
Sport Physiology
پژوهشي
Research
<strong><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">زمینه و هدف:</span></span></span></strong><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;"> در چاقی، آدیپوکاین­هایی که از بافت چربی ترشح می­شوند، التهاب ایجاد می­کنند و باعث عوارض جانبی می­شوند. در میان گستره وسیع آدیپوکاین­ها، آپلین به ­دلیل ارتباط با شاخص­های ترکیب بدن مانند؛ درصد چربی، شاخص­های التهابی و مقاومت به انسولین مورد توجه پژوهشگران قرار گرفته است.</span> هدف از پژوهش حاضر، تعیین و بررسی تأثیر تمرین ترکیبی(استقامتی و قدرتی) بر سطوح آپلین، اینترلوکین ـ6 و پروتئین واکنشیـ­</span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;"> C</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">در مردان میانسال کم­تحرک چاق بود.</span></span></span><br>
<br>
<strong><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">روش بررسی:</span></span></span></strong><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;"> در یک مطالعه تجربی،30 مرد 48 تا 60 سال با میانگین قد51/7±43/174 سانتی­متر، میانگین وزن 26/5±53/93 کیلوگرم و </span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">شاخص توده بدن </span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">81/0±88/30</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">کیلوگرم بر متر­مربع به صورت هدفمند انتخاب شدند و به طور تصادفی در دو گروه کنترل(تعداد=15) و تمرین ترکیبی(تعداد= 15) تقسیم شدند. <span style="letter-spacing: -0.3pt;">برنامه تمرینی شامل 12 هفته تمرین ترکیبی استقامتی و قدرتی بود. </span>نمونهگیری خونی قبل و بعد از 12 هفته برای اندازه­گیری آپلین</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">،</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;"> اینترلوکینـ6</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">، </span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">پروتئین واکنشیـ­</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;"> C</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">و شاخص مقاومت به انسولین انجام گرفت. دادههای جمعآوری شده با استفاده از آزمونهای تی وابسته و مستقل تحلیل شدند. </span></span></span><br>
<br>
<strong><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">یافته­ها: </span></span></span></strong><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">یافته­های پژوهش نشان</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">داد که</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">برنامه تمرین ترکیبی موجب کاهش معنی­دار </span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">نمایه توده بدن</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">ی(002/0=</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">p</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">)</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">، درصد چربی </span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">(001/0=</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">p</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">)</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">، شاخص مقاومت به انسولین</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">(019/0=</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">p</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">)</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">، شاخص­های التهابی</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;"> اینترلوکینـ6 (001/0=</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">p</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">)</span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">، </span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">پروتئین واکنشی ـ­</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">C</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">(023/0=</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">p</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">) و آپلین(001/0=</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">p</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">) و افزایش معنی­دار حداکثر</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">اکسیژن</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">مصرفی(002/0=</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">p</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">) و یک تکرار بیشینه(001/0=</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">p</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">) نسبت به گروه کنترل شد. </span></span></span><br>
<br>
<strong><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">نتیجهگیری: </span></span></span></strong><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">به­طورکلی،</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">به­نظر</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">می­رسد 12 هفته تمرین ترکیبی با کاهش وزن و </span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">توده چربی بدن بر</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">بهبود مقاومت</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">به</span></span></span> <span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">انسولین، شاخص­های التهابی (اینترلوکین ـ6 و پروتئین واکنشی ـ ­</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: arial,sans-serif;"><span style="color: black;">C</span></span></span></span><span style="font-size: 10pt;"><span style="font-family: yagut;"><span style="color: black;">) و کاهش سطوح آپلین تأثیرگذار باشد.</span></span></span><br>
<br>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"><b><span style="color: black; font-family:;">Background & aim: </span></b><span><span lang="EN" style="color: black; font-family:;">In obesity, adipokines is secreted from adipose tissue induced inflammation, causing adverse effects. </span></span><span lang="EN" style="color: black; font-family:;">Among the wide range of adipokines, aplein has been considered by researchers due to association with body composition indices such as fat percentage, inflammatory markers and insulin resistance. The aim of this study was to investigate the effect of </span><span style="color: black; font-family:;">concurrent</span><span><b><span style="color: black; font-family:;"> </span></b></span><span><span lang="EN" style="color: black; font-family:;">training</span></span><b><span lang="EN" style="color: black; font-family:;"> </span></b><span lang="EN" style="color: black; font-family:;">(</span><span lang="EN" style="color: black; font-family:;">endurance and strength) on apelin, interleukin-6, C-reactive protein levels in middle-aged sedentary </span><span><span style="color: black; font-family:;">obese</span></span><span><span lang="EN" style="color: black; font-family:;"> men.</span></span><span lang="EN" style="color: black; font-family:;"> </span></p>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"><b><span style="color: black; font-family:;"> </span></b></p>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"><b><span style="color: black; font-family:;">Methods:</span></b><span><span style="color: black; font-family:;"> </span></span><span style="color: black; font-family:;">In this present quasi-experimental study, 30 men, aged between 48 to 60 years</span><span><span lang="EN" style="color: black; font-family:;">, with mean height</span></span><span lang="EN" style="color: black; font-family:;"> of 174.43±7.51 cm, mean weight of 93/53±5.26 kg and mean BMI of 30.88±0.81 kg/m<sup>2</sup></span><span style="color: black; font-family:;"> were <em><span style="font-family:;">selected purposefully,</span></em><i> </i>and randomly allocated to the concurrent training (n=15) and control groups (n=15).</span><span style="color: black; font-family:;"> </span><span style="color: black; font-family:;">The training program consisted 12 weeks of concurrent</span><span><b><span style="color: black; font-family:;"> </span></b></span><span><span style="color: black; font-family:;">endurance and strength<b> </b></span></span><span><span lang="EN" style="color: black; font-family:;">training</span></span><span lang="EN" style="color: black; font-family:;">. Blood samples were collected for measurements </span><span style="color: black; font-family:;">of </span><span><span lang="EN" style="color: black; font-family:;">apelin</span></span><span lang="EN" style="color: black; font-family:;">, interleukin-6, C-reactive protein and insulin resistance index before and after 12 weeks</span><span style="color: black; font-family:;">.</span><span style="color: black; font-family:;"> </span><span style="color: black; font-family:;">Paired sample t-test and Independent were used to analyze the data (p <0.05).</span></p>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"><b><span style="color: black; font-family:;"> </span></b></p>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"><b><span style="color: black; font-family:;">Result: </span></b><span><span lang="EN" style="color: black; font-family:;">Research findings</span></span><span lang="EN" style="color: black; font-family:;"> presented that the </span><span style="color: black; font-family:;">concurrent</span><span><b><span style="color: black; font-family:;"> </span></b></span><span><span lang="EN" style="color: black; font-family:;">training</span></span><b><span lang="EN" style="color: black; font-family:;"> </span></b><span lang="EN" style="color: black; font-family:;">may</span><span lang="EN" style="color: black; font-family:;"> significantly reduce Body Mass Index (p=0.002), insulin resistance index (p=0.001), inflammatory indices of interleukin-6 (p=0.001), C-reactive protein (p=0.023) and apelin (p=0.001) and significantly increase maximal oxygen consumption (p=0.002) and one repetition maximum (p=0.001)</span><span><span style="color: black; font-family:;"> compared to control group</span></span><span lang="EN" style="color: black; font-family:;">. </span></p>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"><b><span style="color: black; font-family:;"> </span></b></p>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"><b><span style="color: black; font-family:;">Conclusion:</span></b><span><span style="color: black; font-family:;"> </span></span><span style="color: black; font-family:;">Generally, </span><span lang="EN" style="color: black; font-family:;">it appeared that </span><span style="color: black; font-family:;">12 weeks of concurrent</span><span><b><span style="color: black; font-family:;"> </span></b></span><span><span lang="EN" style="color: black; font-family:;">training</span></span><b><span lang="EN" style="color: black; font-family:;"> </span></b><span lang="EN" style="color: black; font-family:;">with<b> </b>decreasing weight and body fat was effective in improving insulin resistance, inflammatory indices (interleukin-6 and C-reactive protein) and reducing aplein levels. </span></p>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"><span style="color: black; font-family:;"> </span></p>
<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; unicode-bidi: embed; direction: ltr;"></p>
آپلین, اینترلوکین ـ6, پروتئین واکنشی سی, تمرین ترکیبی, مردان چاق
Apelin, Concurrent Training, C- reactive Protein, Interleukin-6, Obese Men
446
460
http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-764-2&slc_lang=fa&sid=1
R
Soori
رحمان
سوری
soori@ut.ac.ir
100319475328460018144
100319475328460018144
Yes
Department of Exercise Physiology, University of Tehran, Tehran, Iran
گروه فیزیولوژی ورزشی، دانشگاه تهران، تهران، ایران
M
Darabi
محمد
دارابی
exercisephysilogygroup@gmail.com
100319475328460018145
100319475328460018145
No
Department of Exercise Physiology, University of Tehran, Tehran, Iran
گروه فیزیولوژی ورزشی، دانشگاه تهران، تهران، ایران
Z
Mosadegh Neishabouri
کیا
رنجبر
exercisephysilogygroup@gmail.com
100319475328460018146
100319475328460018146
No
Department of Exercise Physiology, Modaress University, Tehran, Iran
گروه فیزیولوژی ورزش، دانشگاه تربیت مدرس، تهران، ایران
A
Ramezankhani
زهرا
مصدق نیشابوری
exercisephysilogygroup@gmail.com
100319475328460018147
100319475328460018147
No
Department of Exercise Physiology, University of Tehran, Tehran, Iran
گروه فیزیولوژی ورزشی، دانشگاه تهران، تهران، ایران
اعظم
رمضان خانی
ramezankhaniazam@gmail.com
100319475328460018148
100319475328460018148
No
Department of Exercise Physiology, University of Tehran, Tehran, Iran
گروه فیزیولوژی ورزشی، دانشگاه تهران، تهران، ایران