Armaghane Danesh
ارمغان دانش
armaghanj
Medical Sciences
http://armaghanj.yums.ac.ir
1
admin
1728-6506
1728-6514
10.61186/armaghanj
en
jalali
1397
5
1
gregorian
2018
8
1
23
3
online
1
fulltext
fa
تأثیر دو هفته تمرین تناوبی شدید بر سطوح پروتئین SDF-1α، گیرنده آن(CXCR4) وC-Kit در قلب موشهای صحرایی نر
The Effect of two Weeks of Severe Periodic Training on SDF-1α Protein, its Receptor (CXCR4) and C-Kit in the Heart of Male Rats
فیزیولوژی ورزش
Sport Physiology
پژوهشي
Research
<strong><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;">چکیده</span></span></span></strong><br>
<br>
<span style="font-size: medium;"><strong><span style="font-family: yagut;"><span style="color: black;">زمینه و هدف:</span></span></strong></span> <span style="font-family: yagut;"><span style="color: black;">تمرین ورزشی سطوح بافتی </span></span><span style="font-family: yagut;"><span style="color: black;">سلول­های بنیادی و </span></span><span style="font-family: yagut;"><span style="color: black;">عوامل فراخوان کننده، این سلول</span></span><span dir="LTR"><span style="font-family: times new roman,serif;"><span style="color: black;"></span></span></span><span style="font-family: yagut;"><span style="color: black;">ها را در جهت بازسازی و تکثیر سلول</span></span><span dir="LTR"><span style="font-family: times new roman,serif;"><span style="color: black;"></span></span></span><span style="font-family: yagut;"><span style="color: black;">های قلبی افزایش می­دهد، به هر حال اثر بخشی یک دوره کوتاه مدت تمرین شدید مشخص نشده است.</span></span> <span style="font-family: yagut;"><span style="color: black;">بر همین اساس هدف از پژوهش حاضر تعیین اثر دو هفته تمرین تناوبی شدید بر </span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">SDF-1α</span></span></span></span><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;">، گیرنده آن</span></span></span><span style="font-size: 7pt;"><span style="font-family: yagut;"><span style="color: black;">(</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">CXCR4</span></span></span></span><span style="font-size: 7pt;"><span style="font-family: yagut;"><span style="color: black;">)</span></span></span><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;"> و </span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">C-Kit</span></span></span></span><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;"> در بافت قلب موشهای صحرایی نر بود.</span></span></span><br>
<br>
<span style="font-size: medium;"><strong><span style="font-family: yagut;"><span style="color: black;">روش بررسی: </span></span></strong></span><span style="font-family: yagut;"><span style="color: black;">این مطالعه تجربی روی 10 سر موش نر 8</span></span> <span style="font-family: yagut;"><span style="color: black;">هفته</span></span><span dir="LTR"><span style="font-family: times new roman,serif;"><span style="color: black;">­</span></span></span><span style="font-family: yagut;"><span style="color: black;">ای ویستار(با وزن 7/8+75/234 گرم) در دو گروه کنترل و تمرین انجام شد. گروه تمرینی دو هفته تمرین تناوبی شدید</span></span> <span style="font-family: yagut;"><span style="color: black;">در چهار بخش انجام دادند. بخش اول شامل سه روز تمرین</span></span><span style="font-family: yagut;"><span style="color: black;">،</span></span><span style="font-family: yagut;"><span style="color: black;"> روزی دو جلسه و هر جلسه شامل 4 تناوب 2 دقیقه­ای شدید و 3 تناوب آهسته 2 دقیقه­ای بین دو تناوب شدید بود. بخش دوم نیز؛ دو روز تمرین مشابه بخش اول بود،</span></span> <span style="font-family: yagut;"><span style="color: black;">با این تفاوت که شدت تناوب­های شدید و آهسته بیشتر شد. بخش سوم سه روز تمرین به همراه یک تناوب بیشتر و با شدت بخش دوم انجام شد و بالاخره بخش چهارم نیز با یک تناوب بیشتر نسبت به بخش سوم با همان شدت بخش دوم انجام شد. 48 ساعت بعد از آخرین جلسه تمرین، موش­ها</span></span> <span style="font-family: yagut;"><span style="color: black;">بی­هوش و پس از جراحی بافت قلب آنها خارج و به سرعت فریز شد.</span></span> <span style="font-family: yagut;"><span style="color: black;">غلظت پروتئین­های</span></span> <span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">SDF-1α</span></span></span></span><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;">، </span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">CXCR4</span></span></span></span><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;"> و</span></span></span> <span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">C-Kit</span></span></span></span><span style="font-size: medium;"><span style="font-family: yagut;"><span style="color: black;"> با روش وسترن بلات اندازه­گیری شدند.</span></span></span> <span style="font-family: yagut;"><span style="color: black;">داده</span></span><span dir="LTR"><span style="font-family: times new roman,serif;"><span style="color: black;"></span></span></span><span style="font-family: yagut;"><span style="color: black;">ها با استفاده از آزمون آماری تی مستقل تجزیه و</span></span> <span style="font-family: yagut;"><span style="color: black;">تحلیل شدند.</span></span><br>
<br>
<span style="font-size: medium;"><strong><span style="font-family: yagut;"><span style="color: black;">یافته</span></span></strong></span><strong><span dir="LTR"><span style="font-family: times new roman,serif;"><span style="color: black;"></span></span></span></strong><strong><span style="font-family: yagut;"><span style="color: black;">ها:</span></span></strong> <span style="font-family: yagut;"><span style="color: black;">نتایج حاصل از تحلیل آزمون آماری</span></span><span style="font-family: yagut;"><span style="color: black;"> تی مستقل نشان داد غلظت پروتئین بافتی </span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">SDF-1α</span></span></span></span><span style="font-size: medium;"><span style="font-family: yagut;"><span style="color: black;"> گروه تمرینی در مقایسه با گروه کنترل افزایش معنی</span></span></span><span dir="LTR"><span style="font-family: times new roman,serif;"><span style="color: black;"></span></span></span><span style="font-family: yagut;"><span style="color: black;">داری داشت(038/0</span></span><span dir="LTR"><span style="font-size: 9pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">p<</span></span></span></span><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;">) ، همچنین غلظت پروتئین </span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">CXCR4</span></span></span></span><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;"> گروه تمرینی نسبت به گروه کنترل (002/0</span></span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">p</span></span></span></span><span dir="LTR"><span style="font-size: 9pt;"><span style="font-family: times new roman,serif;"><span style="color: black;"><</span></span></span></span><span style="font-size: medium;"><span style="font-family: yagut;"><span style="color: black;">) </span></span></span><span style="font-family: yagut;"><span style="color: black;">و</span></span> <span style="font-family: yagut;"><span style="color: black;">مقادیر پروتئین</span></span> <span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">C-Kit</span></span></span></span><span style="font-size: medium;"> <span style="font-family: yagut;"><span style="color: black;">در بافت قلب گروه تمرینی در مقایسه با گروه کنترل افزایش معن</span></span></span><span style="font-family: yagut;"><span style="color: black;">ی</span></span><span style="font-family: yagut;"><span style="color: black;">داری وجود داشت(023/0</span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">p</span></span></span></span><span dir="LTR"><span style="font-size: 9pt;"><span style="font-family: times new roman,serif;"><span style="color: black;"><</span></span></span></span><span style="font-size: medium;"><span style="font-family: yagut;"><span style="color: black;">)</span></span></span><span style="font-family: yagut;"><span style="color: black;"> و </span></span><span style="font-family: yagut;"><span style="color: black;">(05/0</span></span><span dir="LTR"><span style="font-size: 8pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">p</span></span></span></span><span dir="LTR"><span style="font-size: 9pt;"><span style="font-family: times new roman,serif;"><span style="color: black;">≥</span></span></span></span><span style="font-family: yagut;"><span style="color: black;"><span style="font-size: medium;">).</span></span></span><br>
<br>
<span style="font-size: medium;"><strong><span style="font-family: yagut;"><span style="color: black;">نتیجهگیری: </span></span></strong></span><span style="font-family: yagut;"><span style="color: black;">به نظر می­رسد </span></span><span style="font-family: yagut;"><span style="color: black;">حتی یک دوره کوتاه مدت تمرینهای تناوبی شدید می­تواند از طریق تحریک عوامل فراخوان کننده سلولهای بنیادی موجب تشکیل میوسیتهای جدید گردد.</span></span><br>
<br>
<p style="margin: 0cm 0cm 0pt; line-height: normal;"><b><span new="" style="color: black; font-family:;" times="">Abstract</span></b></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><b><span dir="RTL" lang="AR-SA" style="color: black; font-family:;"> </span></b></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><b><span style="color: black; font-family:;">Background & Aim: </span></b><span style="color: black; font-family:;">Exercise training increases the levels of stem cells and recalling cells of these cells in order to rebuild and proliferate the cells of the heart. However, the effect of a short period of intense exercise has not been determined. The aim of this study was to determine the effect of two weeks of severe routine training on SDF-1α, its receptor (CXCR4) and C-Kit in the rat heart tissue.</span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><span style="color: black; font-family:;"> </span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><b><span style="color: black; font-family:;">Methods:</span></b><span style="color: black; font-family:;"> This experimental study was performed on 10 male Wistar 8 weeks old (234.5 ± 8.7 g) in both control and exercise groups. The experimental group performed two weeks of severe periodic training in four parts. The first part consisted of three days of exercise, two sessions a day, and each session included 4 severe 2 minute movements and 3 slow 2-minute alternations between two severe periods. The second part also: The two days of the training were similar to the first part, with the difference that the severity of the frequencies increased sharply. The third part was a three-day training with a more frequent and intense second part. Finally, the fourth part was more frequent than the third one with the same severity of the second part. 48 hours after the last training session, the mice bleached, and after surgery, the heart tissue was removed and quickly faded. The concentrations of SDF-1α, cxcr4 and C-Kit proteins were measured by western blot method. Data were analyzed by independent t-test.</span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><span style="color: black; font-family:;"> </span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><b><span style="color: black; font-family:;">Results: </span></b><span style="color: black; font-family:;">Independent t-test analysis showed that the SDF-1α protein concentration of the training group was significantly higher than the control group (p <0.038), as well as the concentration of CXCR4 protein in the training group compared to the control group (p <0.002) There was a significant increase in C-Kit protein content in the heart tissue of the training group compared to the control group (p <0.023) , (p≥0.05).</span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><span style="color: black; font-family:;"> </span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><b><span style="color: black; font-family:;">Conclusion:</span></b><span style="color: black; font-family:;"> It seems that even a short period of intense periodic exercises can lead to the formation of new myocytes by stimulating the recalling factors of stem cells.</span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><span style="color: black; font-family:;"> </span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><span style="color: black; font-family:;"> </span></p>
<p style="background: white; margin: 0cm 0cm 0pt; text-align: justify; line-height: normal; tab-stops: 45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt;"><span style="color: black; font-family:;"> </span></p>
تمرین تناوبی شدید
Severe periodic training, SDF-1α, C-kit, CXCR4
317
333
http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1437-1&slc_lang=fa&sid=1
H
Rajabi
حمید
رجبی
hrajabi1346@gmail.com
100319475328460015580
100319475328460015580
Yes
Department of Physical Education, Kharazmi University, Tehran, Iran,
گروه تربیت بدنی، دانشگاه خوارزمی، تهران، ایران،
F
Nasirinezhad
فریناز
نصیری نژاد
fnasirinejad@gmail.com
100319475328460015581
100319475328460015581
No
Department of Physiology, Iran University of Medical Sciences, Tehran, Iran
گروه فیزیولوژی، دانشگاه علوم پزشکی ایران، تهران، ایران
M
Bapiran
محسن
باپیران
mohssenbapiran@gmail.com
100319475328460015582
100319475328460015582
No
Department of Physical Education, Kharazmi University, Tehran, Iran,
گروه تربیت بدنی، دانشگاه خوارزمی، تهران، ایران،
F
Ramezani
فاطمه
رمضانی
framezani2014@gmail.com
100319475328460015583
100319475328460015583
No
Department of Physiology, Iran University of Medical Sciences, Tehran, Iran
گروه فیزیولوژی، دانشگاه علوم پزشکی ایران، تهران، ایران