TY - JOUR JF - yums-armaghan JO - armaghanj VL - 24 IS - 3 PY - 2019 Y1 - 2019/7/01 TI - Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney TT - تأثیر تمرین هوازی و مصرف ال کارنیتین بر برخی فاکتورهای استرس اکسیداتیو کلیه موش صحرایی دیابتی N2 - Abstract Background & aim: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and consumption of l-carnitine on some of the oxidative stress factors in diabetic kidney. Methods: In the present experimental study, 45 male Wistar rats(200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving l-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving l-carnitine. Rats were diabetic peritoneal injected with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily of 100 mg of l-carnitine orally. The aerobic exercise protocol included five sessions per week on the treadmill. Data were analyzed by two way ANOVA and Tukey post hoc test at P <0.05. Results: Six weeks of aerobic exercise, supplementation of l-carnitine and combined intervention of aerobic exercise and supplementation of l-carnitine do not have a significant effect on MDA and SOD factors of kidney tissue in diabetic rats(p>0.05). However, six weeks of aerobic exercise had a significant effect on GPX factor in kidney tissue in diabetic rats (p=0.003). Moreover, supplementation and combined intervention of aerobic exercise and supplementation of l-carnitine did not have a significant effect on GPX factor of kidney tissue in diabetic rats (p>0.05) Conclusion: L-carnitine supplementation intake with regular exercise can have beneficial effects on the body, antioxidant defense system and decreases oxidative stress in rats with type 2 diabetes. SP - 293 EP - 305 AU - Fakourian, A AU - Matinhomaee, H AU - Azarbayjani, MA AU - Farzanegi, P AD - Department of Physical Education and Sport Science, Islamic Azad University, Central Tehran Branch, Tehran, Iran KW - Aerobic training KW - L-carnitine KW - Diabetes KW - SOD KW - GPX KW - MDA KW - Kidney UR - http://armaghanj.yums.ac.ir/article-1-2385-en.html DO - 10.52547/armaghanj.24.3.293 ER -