AU - Ahmadi, r AU - Amini, n AU - Ghasemi, a AU - Seif, a TI - The Effects of Shisheh on the Hormonal Axis Hypothalamus - Pituitary - Thyroid function in adult male Wistar Rats PT - JOURNAL ARTICLE TA - yums-armaghan JN - yums-armaghan VO - 19 VI - 8 IP - 8 4099 - http://armaghanj.yums.ac.ir/article-1-132-en.html 4100 - http://armaghanj.yums.ac.ir/article-1-132-en.pdf SO - yums-armaghan 8 ABĀ  - Background & aim: Studies show that amphetamines can influence the hypothalamic-pituitary-thyroid axis. The aim of this study was to investigate the effects of Shisheh (met-amphetamine) on serum levels of T3, T4 and TSH in male rats. Methods: In this laboratory experimental study 25 male Wistar rats were randomly divided to control, saline receiving, 2mg/kg, 4mg/kg, and 6mg/kg of Shisheh receiving groups of 5 rats in each. The injection was carried out intraperitoneally once a week for 6 weeks. After serum collection, T3, T4 and TSH levels were measured using ELFA method and the data were statically analyzed using ANOVA. Results: Serum level of T3 and T4 was not significantly changed in rats receiving 2mg/kg of Shisheh compared with control animals. Serum level of T3 and T4 was signifintly increased in animals receiving 4mg/kg and 6mg/kg dose of Shisheh compared with the control rats (P CP - IRAN IN - LG - eng PB - yums-armaghan PG - 685 PT - Research YR - 2014