TY - JOUR JF - yums-armaghan JO - armaghanj VL - 14 IS - 1 PY - 2009 Y1 - 2009/4/01 TI - Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache TT - تعیین اثر داروی توپیرامات در پیشگیری از حملات سردرد میگرنی مقاوم به درمان N2 - ABSTRACT Introduction & objective: Migraine is the most common cause of headache. The aim of the present study was to evaluate the effects of topiramate (TPM) in the prevention of drug-resistant migraine headache. Materials & Methods: This is a double-blind clinical trial conducted on 70 patients between ages 15 to 45 years referred to the Bu Ali Sina Hospital in Sari with a history of migraine attacks based on International Headache Society criteria for a period of more than one years with a minimum incidence of 1 to 6 attacks per month. The drug rate performance was assessed by response rate to treatment, mean changes in the number and severity of migraine attacks compared with the placebo group for 3 months. Collected data were analyzed using analysis of variance (ANOVA), Newman-Keuls and Spearman’s Coefficient Rank Correlation as the post hoc tests. GRAPHPAD software was used for analysis of the data. Results: 66 of 70 patients completed the study. The mean age of the patients was 30.33±7.9 years. A significant reduction in the severity and frequency of migraine attacks was seen in all months (P < 0.0001) for topiramate treated group in compare to placebo group. Responder rate for patients treated with TPM was significantly higher than placebo group (63.6%, P SP - 1 EP - 11 AU - Khani, H AU - Abedini, M AU - Zarvani, A AU - Azadmarzabadi, A AU - Roshanbakhash, A AU - Roshanbakhash, R AU - Ghorbani, A AD - UR - http://armaghanj.yums.ac.ir/article-1-540-en.html ER -