TY - JOUR T1 - Evaluation of Antinociceptive Effect of Methanolic Extract of Lallemantia iberica in Adult Male Rats TT - بررسی اثر ضد دردی عصاره متانولی گیاه بالانگو در موش صحرایی نر بالغ JF - yums-armaghan JO - yums-armaghan VL - 19 IS - 12 UR - http://armaghanj.yums.ac.ir/article-1-99-en.html Y1 - 2015 SP - 1058 EP - 1068 KW - Pain KW - extract KW - Lallemantia iberica KW - Rat N2 - Background & aim: The use of common chemical agents in the treatment of pain causes digestive problems. Lallemantia iberica in traditional medicine has been used for the treatment of inflammation and neurological diseases. The purpose of this study was to evaluate the analgesic effect(s) of ethanol extracts of Lallemantia iberica in male rats. Methods: In the present experimental study, 42 adult male rats were divided into 7 groups: control, treated with the Lallemantia iberica at doses of (80, 100 and 300 mg/kg, i.p. morphine (1mg/kg, i.p.), aspirin (1mg/kg, i.p.), and naloxone (1 mg/kg, i.p.) with dose of 300 mg/kg. The analgesic effects of HRC were assessed with writhing, tail-flick and formalin tests. The data were compared by One-way ANOVA test. Results: Lallemantia iberica leaf extract significantly inhibited the number of contractions induced by acetic acid. All doses of HRC showed antinociceptive activity in the tail flick model. In formalin test, the highest effect was observed at dose of 300 mg/kg (P M3 ER -