Background & aim: Diabetes is as a chronic disorder, which produce lots of limitation in patients' activities and psychological quality. The aim of the present study was to investigate the efficacy of cognitive-behavioral therapy based on Lazarus's multimodal approach to psychological weakness and thoughts fusion among diabetic patients with wounds.
 
Methods: The present study was a semi-experimental (pre-test, post-test) with a control and experimental group. The statistical population of study consisted of 50 diabetic patients with wounds in Tabriz Sina Hospital, 24 patients with Purposive sampling selected and randomly divided into two experimental and control groups (each group was 12). The experimental group participated in group sessions for 8 sessions of 120 minutes, while the control group did not receive any intervention. Subjects in both experimental and control groups were assessed with the Minnesota Multiplier Questionnaire (MMPI) Questionnaire (Pt sub-scale) and Thought Fusion Inventory (TFI) before and after treatment. Data were analyzed by descriptive statistics (such as mean and standard deviation), ANCOVA and MANCOVA.
 
Results: Results indicated that there were significant differences in post-test mean scores of experimental and control groups and cognitive behavior therapy could significantly reduce psychological weakness (F=41/138, p=0.01) and increase thought fusion (F=9/306, P<0.007).
Conclusion: Cognitive behavioral therapy with changing maladaptive thought and helping to accept disease, resulted in behavior change in diabetic patients.